INT56285

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Context Info
Confidence 0.81
First Reported 1994
Last Reported 2005
Negated 0
Speculated 1
Reported most in Abstract
Documents 10
Total Number 14
Disease Relevance 1.65
Pain Relevance 6.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SCG2) extracellular region (SCG2) intracellular (SCG2)
Anatomy Link Frequency
neurons 2
eye 1
leukocyte 1
nerve 1
spinal cord 1
SCG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 58 100.00 Very High Very High Very High
qutenza 39 100.00 Very High Very High Very High
c fibre 10 100.00 Very High Very High Very High
Enkephalin 8 100.00 Very High Very High Very High
substance P 10 99.92 Very High Very High Very High
cytokine 6 98.76 Very High Very High Very High
Spinal cord 33 98.72 Very High Very High Very High
amygdala 4 95.20 Very High Very High Very High
Dorsal horn 4 93.68 High High
Neurotransmitter 1 93.40 High High
Disease Link Frequency Relevance Heat
Rhinitis 4 100.00 Very High Very High Very High
Nociception 12 98.20 Very High Very High Very High
Ganglion Cysts 2 95.84 Very High Very High Very High
Fibrosis 1 87.92 High High
Cirrhosis 1 86.80 High High
INFLAMMATION 2 86.32 High High
Atherosclerosis 2 85.60 High High
Stress 1 78.12 Quite High
Necrosis 1 75.00 Quite High
Cancer 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
METHODS: The presence of secretoneurin in nasal biopsies and its release in response to nasal capsaicin and histamine challenges were examined.
Localization (release) of secretoneurin in nasal
1) Confidence 0.81 Published 2005 Journal Allergy Section Body Doc Link 15727576 Disease Relevance 0 Pain Relevance 0
Secretoneurin (SN), a 33-amino acid neuropeptide, is derived from secretogranin II that is released from sensory afferent C-fibers by capsaicin.
Localization (released) of secretogranin II associated with c fibre, qutenza and neuropeptide
2) Confidence 0.79 Published 1998 Journal Blood Section Abstract Doc Link 9473216 Disease Relevance 0 Pain Relevance 0.45
Secretoneurin is released into human airways by topical histamine but not capsaicin.
Localization (released) of Secretoneurin associated with qutenza
3) Confidence 0.71 Published 2005 Journal Allergy Section Title Doc Link 15727576 Disease Relevance 0.09 Pain Relevance 0.45
In this immunocytochemical study we investigated the localization of secretoneurin-like immunoreactivity in the human substantia innominata in relation to the ventral striatopallidal system, the bed nucleus-amygdala complex and the basal nucleus of Meynert.
Spec (investigated) Localization (localization) of secretoneurin-like in nucleus associated with amygdala
4) Confidence 0.71 Published 1997 Journal Synapse Section Abstract Doc Link 9131771 Disease Relevance 0 Pain Relevance 0.27
There is no information on the occurrence and mechanisms of release of secretoneurin in healthy human airways.
Localization (release) of secretoneurin
5) Confidence 0.70 Published 2005 Journal Allergy Section Abstract Doc Link 15727576 Disease Relevance 0.09 Pain Relevance 0.12
BACKGROUND: The neuropeptide secretoneurin, with potential relevance to leukocyte trafficking, is present in nerves of the nasal mucosa in allergic rhinitis and may be released in response to allergen and histamine exposure.
Localization (released) of secretoneurin in leukocyte associated with rhinitis and neuropeptide
6) Confidence 0.70 Published 2005 Journal Allergy Section Abstract Doc Link 15727576 Disease Relevance 0.10 Pain Relevance 0.12
METHODS: The presence and distribution of secretoneurin was investigated in human eyes by radioimmunoassay and immunofluorescence and compared with that of the rat eye.
Localization (distribution) of secretoneurin in eye
7) Confidence 0.69 Published 2005 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 15671295 Disease Relevance 0 Pain Relevance 0
Perfusion of spinal cord slices with capsaicin as well as with 60 mM potassium led to a release of secretoneurin-IR.
Localization (release) of secretoneurin in spinal cord associated with qutenza and spinal cord
8) Confidence 0.59 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 8075827 Disease Relevance 0.12 Pain Relevance 0.99
In conclusion, secretoneurin is a neuropeptide which is stored in and released from capsaicin-sensitive, primary afferent (C-fibre) neurons.
Localization (stored) of secretoneurin in neurons associated with c fibre, qutenza and neuropeptide
9) Confidence 0.55 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 8075827 Disease Relevance 0.21 Pain Relevance 0.99
In conclusion, secretoneurin is a neuropeptide which is stored in and released from capsaicin-sensitive, primary afferent (C-fibre) neurons.
Localization (released) of secretoneurin in neurons associated with c fibre, qutenza and neuropeptide
10) Confidence 0.55 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 8075827 Disease Relevance 0.21 Pain Relevance 0.99
Secretoneurin-immunoreactivity in nerve terminals apposing identified preganglionic sympathetic neurons in the rat: colocalization with substance P and enkephalin.
Localization (colocalization) of Secretoneurin in nerve associated with enkephalin and substance p
11) Confidence 0.54 Published 1995 Journal J. Chem. Neuroanat. Section Title Doc Link 8527038 Disease Relevance 0.10 Pain Relevance 0.72
Human and rat primary C-fibre afferents store and release secretoneurin, a novel neuropeptide.
Localization (release) of secretoneurin associated with c fibre, qutenza and neuropeptide
12) Confidence 0.52 Published 1994 Journal Eur. J. Neurosci. Section Title Doc Link 8075827 Disease Relevance 0.16 Pain Relevance 0.83
Secretoneurin (SN), a novel 33-amino acid neuropeptide derived from secretogranin II (chromogranin C), is widely distributed in the central and peripheral nervous and neuroendocrine systems, including afferent C-fibers, and can be released in the periphery by capsaicin.
Localization (released) of Secretoneurin associated with c fibre, qutenza and neuropeptide
13) Confidence 0.46 Published 1997 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 9351368 Disease Relevance 0.35 Pain Relevance 0.52
The two cytokines also stimulated the basal as well as depolarization-provoked release of enkephalin and secretoneurin from chromaffin cells.
Localization (release) of secretoneurin in chromaffin cells associated with enkephalin and cytokine
14) Confidence 0.06 Published 2004 Journal Mol. Endocrinol. Section Abstract Doc Link 15087472 Disease Relevance 0.23 Pain Relevance 0.47

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