INT56290

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1994
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 79
Total Number 81
Disease Relevance 47.98
Pain Relevance 31.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) aging (Il6) extracellular region (Il6)
Anatomy Link Frequency
neutrophil 10
Macrophages 6
T cells 6
plasma 4
fibroblasts 4
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 670 100.00 Very High Very High Very High
cytokine 389 100.00 Very High Very High Very High
agonist 290 100.00 Very High Very High Very High
anesthesia 86 100.00 Very High Very High Very High
Inflammatory mediators 46 100.00 Very High Very High Very High
Eae 38 100.00 Very High Very High Very High
Morphine 25 99.98 Very High Very High Very High
ketamine 24 99.98 Very High Very High Very High
vagus nerve 5 99.98 Very High Very High Very High
corticosteroid 62 99.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 763 100.00 Very High Very High Very High
Injury 135 100.00 Very High Very High Very High
Cancer 72 100.00 Very High Very High Very High
Necrosis 50 100.00 Very High Very High Very High
Ulcers 4 100.00 Very High Very High Very High
Recurrence 2 100.00 Very High Very High Very High
Hematological Disease 1 99.92 Very High Very High Very High
Esophageal Cancer 2 99.84 Very High Very High Very High
Experimental Autoimmune Neuritis 32 99.74 Very High Very High Very High
Hypothermia 56 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We observed that minocycline which was reported to have a neuroprotective effect in some neurodegenerative diseases, reversed hyperalgesia and allodynia due to sciatic nerve ligation and inhibited the interleukin-6 production.
Negative_regulation (inhibited) of Gene_expression (production) of interleukin-6 in sciatic nerve associated with hyperalgesia, allodynia, sciatic nerve and neurodegenerative disease
1) Confidence 0.59 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16687137 Disease Relevance 0.89 Pain Relevance 1.01
In vitro cell study further demonstrated that the opioidergic agonists, delta and kappa, but not mu, attenuated IL-6 production from stimulated glial cells.
Negative_regulation (attenuated) of Gene_expression (production) of IL-6 in glial cells associated with agonist
2) Confidence 0.53 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 18294735 Disease Relevance 0.70 Pain Relevance 0.89
CONCLUSIONS: Isoflurane anesthesia administered simultaneously with the injection of LPS decreases serum production of TNF-alpha and IL-6 despite bilateral transection of the vagus nerve.
Negative_regulation (decreases) of Gene_expression (production) of IL-6 in vagus nerve
3) Confidence 0.48 Published 2005 Journal Surgery Section Body Doc Link 16269307 Disease Relevance 0 Pain Relevance 0
Although it is well accepted that CS also inhibit the expression of many cytokines including IL-6 in inflammation, it is not known if CS exhibits similar effects in healthy animals.
Negative_regulation (inhibit) of Gene_expression (expression) of IL-6 associated with corticosteroid, inflammation and cytokine
4) Confidence 0.46 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0.52 Pain Relevance 0.26
Ketamine only at a dose of 50 mg/kg inhibited TNF-alpha and IL-6 production, and decreased MPO activity and wet/dry weight ratio after endotoxin challenge.
Negative_regulation (inhibited) of Gene_expression (production) of IL-6
5) Confidence 0.43 Published 2005 Journal Inflamm. Res. Section Body Doc Link 15883747 Disease Relevance 0.06 Pain Relevance 0
Administration of tramadol postoperatively also suppressed the c-fos expression and serum IL-6 production as showed in PT10 but were weaker than those in Group T10.
Negative_regulation (suppressed) of Gene_expression (production) of IL-6
6) Confidence 0.43 Published 2009 Journal Zhejiang Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 19693978 Disease Relevance 0 Pain Relevance 0
Pretreatment with tramadol showed a dose-depended inhibitory effect on c-fos expression and serum IL-6 production,but not in Group T1.
Negative_regulation (effect) of Gene_expression (production) of IL-6
7) Confidence 0.43 Published 2009 Journal Zhejiang Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 19693978 Disease Relevance 0 Pain Relevance 0
This explains why in the present study there was a rise in IL-6 levels in all 3 groups as the surgery involved some degree of muscle injury to get access to the knee joint.
Negative_regulation (rise) of Gene_expression (levels) of IL-6 in knee joint associated with injury
8) Confidence 0.43 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2702344 Disease Relevance 1.09 Pain Relevance 0.24
Although the IL-6 levels dropped after 12 hours in all 3 groups, it did not reach the pre operative levels at 24 hours.
Negative_regulation (dropped) of Gene_expression (levels) of IL-6
9) Confidence 0.43 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2702344 Disease Relevance 0.19 Pain Relevance 0.24
Before treatment the patient with Sweet's syndrome had high serum levels of interleukin 6 (IL-6), which were reduced to zero after treatment with steroids.
Negative_regulation (reduced) of Gene_expression (levels) of interleukin 6 associated with syndrome
10) Confidence 0.43 Published 1994 Journal Tidsskr. Nor. Laegeforen. Section Abstract Doc Link 8079262 Disease Relevance 0.73 Pain Relevance 0.18
Although there was no weight gain or improvement in hypoalbuminemia, these results suggest that steroids may suppress the abnormal production of IL-6 in cancer patients and that this action affects symptoms.
Spec (may) Negative_regulation (suppress) of Gene_expression (production) of IL-6 associated with cancer, hypoalbuminemia and weight gain
11) Confidence 0.43 Published 1996 Journal J Pain Symptom Manage Section Abstract Doc Link 8803383 Disease Relevance 0.73 Pain Relevance 0.16
Ketamine suppressed the serum IL-6 response immediately after CPB and 4, 24, and 48 h postoperatively (P < 0.05).
Negative_regulation (suppressed) of Gene_expression (response) of IL-6 associated with ketamine
12) Confidence 0.42 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9706914 Disease Relevance 0.26 Pain Relevance 0.59
High doses of i.v. morphine reduced cortisol and IL-6 levels in the early hours after surgery.
Negative_regulation (reduced) of Gene_expression (levels) of IL-6 associated with morphine
13) Confidence 0.42 Published 1997 Journal Pain Section Abstract Doc Link 9469525 Disease Relevance 0.92 Pain Relevance 1.48
To rule out the possibility that DEX was inhibiting LPS-induced IL-6 release by blocking IL-6 gene expression, we tested the effect of DEX on interleukin 1beta(IL-1)-induced IL-6 release.
Negative_regulation (blocking) of Gene_expression (expression) of IL-6 associated with dexamethasone
14) Confidence 0.42 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9784426 Disease Relevance 0.07 Pain Relevance 0.27
Il6 expression levels were significantly elevated in the whiskers area at 12 hpi and then declined in both strains.
Negative_regulation (declined) of Gene_expression (expression) of Il6 in whiskers associated with sprains and strains
15) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.48 Pain Relevance 0.09
Estrogen protects against cellular infiltration by reducing the expressions of E-selectin and IL-6 in endotoxin-induced uveitis.
Negative_regulation (reducing) of Gene_expression (expressions) of IL-6 associated with uveitis
16) Confidence 0.38 Published 1999 Journal J. Immunol. Section Title Doc Link 10384138 Disease Relevance 1.00 Pain Relevance 0.16
Immunohistochemical analysis of the ankle joints demonstrated that interleukin-6 production was reduced in the tissues and the numbers of osteoclasts present in the joints were also decreased.
Negative_regulation (reduced) of Gene_expression (production) of interleukin-6 in joints
17) Confidence 0.37 Published 2005 Journal J. Autoimmun. Section Abstract Doc Link 16256307 Disease Relevance 0.77 Pain Relevance 0.99
When compared to Naproxen, sham and extra-virgin olive oil, the levels of IL-6 and IL-1alpha were also marginally decreased in rats fed with Lyprinol.
Negative_regulation (decreased) of Gene_expression (levels) of IL-6
18) Confidence 0.36 Published 2008 Journal Eur Ann Allergy Clin Immunol Section Abstract Doc Link 19227651 Disease Relevance 0.63 Pain Relevance 0.44
We investigated the ability of retinoids to suppress IL-6 expression in IL-1-stimulated synovial fibroblasts, with special care to the contribution of retinoic acid receptor (RAR) and retinoid X receptor (RXR) subtypes, and the implication of the mitogen-activated protein kinase (MAPK) pathway.


Negative_regulation (suppress) of Gene_expression (expression) of IL-6 in fibroblasts
19) Confidence 0.36 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2656246 Disease Relevance 0.10 Pain Relevance 0.10
These data led us to postulate that the ability of retinoids to inhibit IL-6 production by activated synovial fibroblasts could have a major role in their antiarthritic potency.
Negative_regulation (inhibit) of Gene_expression (production) of IL-6 in fibroblasts associated with potency
20) Confidence 0.36 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 1.21 Pain Relevance 0.72

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox