INT56291

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Context Info
Confidence 0.63
First Reported 1994
Last Reported 2011
Negated 5
Speculated 4
Reported most in Body
Documents 503
Total Number 508
Disease Relevance 274.12
Pain Relevance 81.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ros1) cell proliferation (Ros1) signal transduction (Ros1)
plasma membrane (Ros1) kinase activity (Ros1)
Anatomy Link Frequency
microglia 19
neutrophils 17
macrophages 15
neurons 13
liver 12
Ros1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 5703 100.00 Very High Very High Very High
cytokine 2103 100.00 Very High Very High Very High
Inflammatory mediators 345 100.00 Very High Very High Very High
agonist 810 99.92 Very High Very High Very High
Inflammatory response 643 99.88 Very High Very High Very High
dorsal root ganglion 1747 99.84 Very High Very High Very High
ischemia 1451 99.84 Very High Very High Very High
qutenza 2142 99.78 Very High Very High Very High
Paracetamol 247 99.74 Very High Very High Very High
chemokine 522 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 6623 100.00 Very High Very High Very High
Injury 2305 100.00 Very High Very High Very High
Toxicity 827 100.00 Very High Very High Very High
Asthma 70 99.98 Very High Very High Very High
Stress 3631 99.88 Very High Very High Very High
Cancer 1193 99.88 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 709 99.88 Very High Very High Very High
Cv Unclassified Under Development 4268 99.84 Very High Very High Very High
Ganglion Cysts 1814 99.84 Very High Very High Very High
Fatty Liver 1497 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Staining of the lenses with DHR was performed at 0 °C (but not frozen) to optimize differential staining of the abnormal ROS present in cataractous lenses with that produced by normal respiration of surface LECs at 37 °C.
Gene_expression (present) of ROS in lenses
1) Confidence 0.63 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2925908 Disease Relevance 0.09 Pain Relevance 0
These cortical areas of abnormal LEC nuclei also express strong reactive oxygen species (ROS), and the appearance of the ROS and extended bow regions correlate to cataract incidence in the old animals [12,19-21].
Gene_expression (express) of ROS associated with cataract
2) Confidence 0.63 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2925908 Disease Relevance 0.51 Pain Relevance 0
These cortical areas of abnormal LEC nuclei also express strong reactive oxygen species (ROS), and the appearance of the ROS and extended bow regions correlate to cataract incidence in the old animals [12,19-21].
Gene_expression (appearance) of ROS associated with cataract
3) Confidence 0.54 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2925908 Disease Relevance 0.52 Pain Relevance 0
As a result O2 levels may rise inside the cortex, resulting in the ROS noted above.
Gene_expression (resulting) of ROS in cortex
4) Confidence 0.54 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2925908 Disease Relevance 0.08 Pain Relevance 0
One can suggest that following furosemide injection, the resulting depression of the cochlear amplifier leads to the synthesis of lower levels of ROS, with less metabolically induced structural damage; while the damage due to elevated levels of ROS is reduced by the anti-oxidants.
Gene_expression (synthesis) of ROS in cochlear associated with depression
5) Confidence 0.53 Published 2010 Journal J Occup Med Toxicol Section Body Doc Link PMC2936911 Disease Relevance 0.26 Pain Relevance 0.05
Thus in the presence of furosemide, the levels of ROS produced are lower so that the addition of anti-oxidant does not provide additional protection over that provided by the furosemide (thus precluding a synergistic effect of the two drugs).
Gene_expression (levels) of ROS
6) Confidence 0.53 Published 2010 Journal J Occup Med Toxicol Section Body Doc Link PMC2936911 Disease Relevance 0.32 Pain Relevance 0.08
Elevated levels of ROS are produced as part of the metabolic processes involved in maintaining adequate electro-chemical gradients (with greater metabolic demand) required to continue auditory transduction in the presence of the noise exposure.
Gene_expression (produced) of ROS
7) Confidence 0.53 Published 2010 Journal J Occup Med Toxicol Section Body Doc Link PMC2936911 Disease Relevance 0 Pain Relevance 0.05
The well-known anti-inflammatory activity of narcotic analgesics could be explained partly by an inhibition of ROS production.
Gene_expression (production) of ROS associated with inflammation and analgesic
8) Confidence 0.53 Published 1994 Journal Agents Actions Section Abstract Doc Link 8079816 Disease Relevance 0.44 Pain Relevance 0.27
Glutathione levels were markedly reduced in S. typhimurium-challenged, inflamed intestinal tissues as a result of ROS generation.
Gene_expression (generation) of ROS
9) Confidence 0.51 Published 1998 Journal Lab. Invest. Section Abstract Doc Link 9605177 Disease Relevance 0.24 Pain Relevance 0.12
Further evidence favoring this mechanism included the capacity of L-histidine to scavenge ROS produced as a result of lipopolysaccharide (LPS) exposure of mononuclear cells (U937), as demonstrated with a redox-sensitive fluorescent dye (2'7'-dichlorodihydrofluorescein [DCF]).
Gene_expression (produced) of ROS in mononuclear cells
10) Confidence 0.51 Published 1998 Journal Lab. Invest. Section Abstract Doc Link 9605177 Disease Relevance 0.27 Pain Relevance 0.17
Because nimesulide, unlike the related nitroaromatic drug nilutamide, did not produce any detectable ROS during incubation with mouse hepatic microsomes, we conclude that mitochondrial uncoupling causes MPT and that ROS production is a secondary effect.
Gene_expression (production) of ROS
11) Confidence 0.51 Published 2005 Journal Free Radic. Biol. Med. Section Abstract Doc Link 16140214 Disease Relevance 0.27 Pain Relevance 0
Because nimesulide, unlike the related nitroaromatic drug nilutamide, did not produce any detectable ROS during incubation with mouse hepatic microsomes, we conclude that mitochondrial uncoupling causes MPT and that ROS production is a secondary effect.
Neg (not) Gene_expression (produce) of ROS
12) Confidence 0.51 Published 2005 Journal Free Radic. Biol. Med. Section Abstract Doc Link 16140214 Disease Relevance 0.30 Pain Relevance 0
X-irradiation would be expected to directly produce short-lived ROS in addition to damage by direct energy transfer to the lens macromolecules.
Gene_expression (produce) of ROS in lens
13) Confidence 0.49 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2925908 Disease Relevance 0.35 Pain Relevance 0
H(2)O(2) levels were significantly raised in the carrageenan-induced hind paw inflammation model, showing that this ROS is produced endogenously in a model of inflammation.
Gene_expression (produced) of ROS in paw associated with inflammation
14) Confidence 0.42 Published 2009 Journal Pain Section Abstract Doc Link 19059721 Disease Relevance 1.21 Pain Relevance 0.86
Thus in the presence of furosemide, the levels of ROS produced are lower so that the addition of anti-oxidant does not provide additional protection over that provided by the furosemide (thus precluding a synergistic effect of the two drugs).
Gene_expression (produced) of ROS
15) Confidence 0.41 Published 2010 Journal J Occup Med Toxicol Section Body Doc Link PMC2936911 Disease Relevance 0.32 Pain Relevance 0.08
Other major sources of ROS and reactive nitrogen species (RNS) formed during inflammatory response include vascular endothelium, Kuffer cells, neutrophils and macrophages.
Gene_expression (sources) of ROS in macrophages associated with inflammatory response
16) Confidence 0.36 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2946038 Disease Relevance 0.54 Pain Relevance 0.17
TRPV1 activation induces increases in ROS production
Gene_expression (production) of ROS
17) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.35 Pain Relevance 0.31
PBN blocks TRPV1 activated increases in ROS production in DRG neurons of wild type mice
Gene_expression (production) of ROS in neurons associated with dorsal root ganglion
18) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.56 Pain Relevance 0.95
Capsaicin increases ROS production in DRG neurons of wild type mice
Gene_expression (production) of ROS in neurons associated with dorsal root ganglion and qutenza
19) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.37 Pain Relevance 0.72
The results are supported in experiments done on synoviocyte cultures showing that ROS production was induced by calcium influxes elicited by TRPV1 activation [40].
Gene_expression (production) of ROS
20) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.11 Pain Relevance 0.46

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