INT56292

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Context Info
Confidence 0.38
First Reported 1994
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 70
Total Number 72
Disease Relevance 36.14
Pain Relevance 9.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ros1) cell proliferation (Ros1) signal transduction (Ros1)
plasma membrane (Ros1) kinase activity (Ros1)
Anatomy Link Frequency
liver 8
plasma 4
heart 4
neutrophils 3
retina 2
Ros1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 694 99.64 Very High Very High Very High
qutenza 368 99.52 Very High Very High Very High
Analgesic 11 99.34 Very High Very High Very High
Bioavailability 2 99.24 Very High Very High Very High
Inflammation 601 99.08 Very High Very High Very High
tolerance 80 98.92 Very High Very High Very High
Central nervous system 25 98.60 Very High Very High Very High
agonist 103 98.20 Very High Very High Very High
fibrosis 59 96.44 Very High Very High Very High
potassium channel 1368 96.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Parkinson's Disease 2146 100.00 Very High Very High Very High
Hypothermia 55 99.98 Very High Very High Very High
Pressure And Volume Under Development 104 99.84 Very High Very High Very High
Neutrophil Disorders 18 99.80 Very High Very High Very High
Death 326 99.72 Very High Very High Very High
Diabetes Mellitus 288 99.72 Very High Very High Very High
Hyperglycemia 90 99.70 Very High Very High Very High
Cv Unclassified Under Development 1353 99.68 Very High Very High Very High
Toxicity 92 99.46 Very High Very High Very High
Stress 624 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The well-known anti-inflammatory activity of narcotic analgesics could be explained partly by an inhibition of ROS production.
Negative_regulation (inhibition) of Gene_expression (production) of ROS associated with inflammation and analgesic
1) Confidence 0.38 Published 1994 Journal Agents Actions Section Abstract Doc Link 8079816 Disease Relevance 0.45 Pain Relevance 0.27
The PBN (2 mM) added 90 min prior to start of recording abolished ROS production induced by capsaicin (1 ?
Negative_regulation (abolished) of Gene_expression (production) of ROS associated with qutenza
2) Confidence 0.27 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.08 Pain Relevance 0.54
In our experiment, blocking ROS production also abolished TNFR1 increases.
Negative_regulation (abolished) of Gene_expression (production) of ROS
3) Confidence 0.27 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.39 Pain Relevance 0.36
PBN was used to block ROS production after TRPV1 activation with capsaicin.
Negative_regulation (block) of Gene_expression (production) of ROS associated with qutenza
4) Confidence 0.27 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.51 Pain Relevance 0.82
In our experiment, blocking ROS production also abolished TNFR1 increases.
Negative_regulation (blocking) of Gene_expression (production) of ROS
5) Confidence 0.27 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.38 Pain Relevance 0.36
The finding that PBN abolished ROS production induced by capsaicin in the study further confirms that elevated ROS production is triggered by TRPV1 activation.
Negative_regulation (abolished) of Gene_expression (production) of ROS associated with qutenza
6) Confidence 0.20 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.78 Pain Relevance 0.70
Determination of ROS production by H2DCFDA fluorescent probe
Negative_regulation (Determination) of Gene_expression (production) of ROS
7) Confidence 0.20 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0 Pain Relevance 0
The profound control of AuNPs over the anti oxidant enzymes such as GSH, SOD, Catalase and GPx in diabetic mice to normal, by inhibition of lipid peroxidation and ROS generation during hyperglycemia evidence their anti-oxidant effect during hyperglycemia.
Negative_regulation (inhibition) of Gene_expression (generation) of ROS associated with hyperglycemia and diabetes mellitus
8) Confidence 0.16 Published 2010 Journal J Nanobiotechnology Section Abstract Doc Link PMC2914719 Disease Relevance 1.04 Pain Relevance 0
Lutein did not affect the metabolic status of the diabetic mice, but it prevented ROS generation in the retina and the visual impairment induced by diabetes.
Negative_regulation (prevented) of Gene_expression (generation) of ROS in retina associated with diabetes mellitus
9) Confidence 0.14 Published 2010 Journal Diabetologia Section Abstract Doc Link PMC2850533 Disease Relevance 1.42 Pain Relevance 0
expression, elicited by reduced ROS levels in the liver, is accompanied by decreased phosphorylation of CREB in db/db mice.
Negative_regulation (reduced) of Gene_expression (levels) of ROS in liver
10) Confidence 0.14 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.05 Pain Relevance 0.03
In the present study, we used overexpression of SOD1 as a strategy to reduce ROS levels in the liver.
Negative_regulation (reduce) of Gene_expression (levels) of ROS in liver
11) Confidence 0.12 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.12 Pain Relevance 0
Hyperglycemia significantly reduced ROS production, which was even more markedly suppressed by Ex4 in a glucose-dependent manner (Fig. 6B).
Negative_regulation (reduced) of Gene_expression (production) of ROS associated with hyperglycemia and agonist
12) Confidence 0.12 Published 2008 Journal Diabetes Section Body Doc Link PMC2551665 Disease Relevance 0.43 Pain Relevance 0.25
Normally, ROS produced during cellular respiration are removed by mitochondrial antioxidant enzymes such as superoxide dismutase 2 (SOD2), which converts superoxide to hydrogen peroxide, which in turn is converted to water and oxygen by glutathione, and catalase.
Negative_regulation (removed) of Gene_expression (produced) of ROS
13) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 1.19 Pain Relevance 0.11
Interestingly, a reduction in ROS production by the antioxidant BHA controls liver cell death and proliferation and reduces carcinogenesis [29].
Negative_regulation (reduction) of Gene_expression (production) of ROS in liver associated with death
14) Confidence 0.10 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.12 Pain Relevance 0.11
Importantly, genetic deletion of Vav from primary microglia resulted in severe attenuation of ROS production following fA?
Negative_regulation (attenuation) of Gene_expression (production) of ROS in microglia
15) Confidence 0.10 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.35 Pain Relevance 0.03
We investigated these factors in the fibrotic response to bleomycin of p47phox -/- (KO) mice, deficient for ROS production through the NADPH-oxidase pathway.


Negative_regulation (deficient) of Gene_expression (production) of ROS associated with fibrosis
16) Confidence 0.09 Published 2005 Journal Respir Res Section Abstract Doc Link PMC548519 Disease Relevance 0.35 Pain Relevance 0.22
mice showed a decrease in macrophage infiltration and ROS production in ischemic muscles, leading to impaired muscle regeneration and increased necrosis and fibrosis.
Negative_regulation (decrease) of in macrophage Gene_expression (production) of ROS in muscles associated with fibrosis and necrosis
17) Confidence 0.08 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2955540 Disease Relevance 0.55 Pain Relevance 0.12
Moreover, thioglycollate-induced peritoneal macrophage recruitment and ROS production were inhibited in IQGAP1?
Negative_regulation (inhibited) of Gene_expression (production) of ROS in peritoneal macrophage
18) Confidence 0.08 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2955540 Disease Relevance 0.42 Pain Relevance 0.08
In the central nervous system, Noh and Koh (2000) were able to demonstrate increased NADPH oxidase-derived (NOX2) ROS production in cortical cultures in response to zinc exposure [72].
Negative_regulation (derived) of Gene_expression (production) of ROS in central nervous system associated with central nervous system
19) Confidence 0.08 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.35 Pain Relevance 0.14
Inhibition of ALDH-2 and mitochondrial ROS formation
Negative_regulation (Inhibition) of Gene_expression (formation) of mitochondrial ROS
20) Confidence 0.08 Published 2006 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1654181 Disease Relevance 0.28 Pain Relevance 0.41

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