INT56298

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Context Info
Confidence 0.78
First Reported 1994
Last Reported 2010
Negated 13
Speculated 5
Reported most in Abstract
Documents 306
Total Number 317
Disease Relevance 182.18
Pain Relevance 72.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL4) extracellular region (IL4)
Anatomy Link Frequency
T cells 36
Th2 cells 10
macrophage 8
lung 8
lymphocytes 7
IL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 6984 100.00 Very High Very High Very High
Inflammation 6311 100.00 Very High Very High Very High
rheumatoid arthritis 3482 100.00 Very High Very High Very High
chemokine 1245 100.00 Very High Very High Very High
antagonist 1121 100.00 Very High Very High Very High
metalloproteinase 919 100.00 Very High Very High Very High
substance P 70 100.00 Very High Very High Very High
Enkephalin 15 100.00 Very High Very High Very High
MU agonist 1 100.00 Very High Very High Very High
Neuritis 35 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 7006 100.00 Very High Very High Very High
Rheumatoid Arthritis 3510 100.00 Very High Very High Very High
Cancer 2042 100.00 Very High Very High Very High
Necrosis 286 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 138 100.00 Very High Very High Very High
Solid Tumor 20 100.00 Very High Very High Very High
Hyperplasia 306 99.96 Very High Very High Very High
Optic Neuritis 22 99.96 Very High Very High Very High
Disease 3091 99.92 Very High Very High Very High
Immunization 89 99.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interleukin 4 (IL-4) is a cytokine produced by activated T-lymphocytes with pluripotent activities including growth inhibition of various tumor cell lines in vitro and immune- mediated tumor growth inhibition in in vivo animal tumor models.
Gene_expression (produced) of IL-4 in T-lymphocytes associated with cancer and cytokine
1) Confidence 0.78 Published 1998 Journal J. Immunother. Section Abstract Doc Link 9807739 Disease Relevance 0.80 Pain Relevance 0.05
Interleukin 4 (IL-4) is a cytokine produced by activated T-lymphocytes with pluripotent activities including growth inhibition of various tumor cell lines in vitro and immune- mediated tumor growth inhibition in in vivo animal tumor models.
Gene_expression (produced) of Interleukin 4 in T-lymphocytes associated with cancer and cytokine
2) Confidence 0.78 Published 1998 Journal J. Immunother. Section Abstract Doc Link 9807739 Disease Relevance 0.80 Pain Relevance 0.05
In the present study, the effect of beta(2)-adrenoceptor agonists was examined on proliferation, interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) production by human peripheral blood mononuclear cells (PBMC).
Spec (examined) Gene_expression (production) of IL-4 in blood associated with agonist
3) Confidence 0.73 Published 1996 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8796447 Disease Relevance 0.10 Pain Relevance 0.09
In contrast, no significant effect of salmeterol (10(-11)-10(-5) M) on IL-4 production could be detected after 96 h.
Gene_expression (production) of IL-4
4) Confidence 0.73 Published 1996 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8796447 Disease Relevance 0.07 Pain Relevance 0.16
Together, the present data provide clear evidence for concentration-dependent effects of beta-adrenoceptor agonists on the IL-4 and IFN-gamma production by human PBMC.
Gene_expression (production) of IL-4 in PBMC associated with agonist
5) Confidence 0.73 Published 1996 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8796447 Disease Relevance 0 Pain Relevance 0.29
A U-shaped concentration response curve was observed for the effect of all agonists on IL-4 production 24 h after PHA activation.
Gene_expression (production) of IL-4 associated with agonist
6) Confidence 0.73 Published 1996 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8796447 Disease Relevance 0.08 Pain Relevance 0.13
Salmeterol inhibits interferon-gamma and interleukin-4 production by human peripheral blood mononuclear cells.
Gene_expression (production) of interleukin-4 in mononuclear cells
7) Confidence 0.73 Published 1996 Journal Int. J. Immunopharmacol. Section Title Doc Link 8796447 Disease Relevance 0.10 Pain Relevance 0.12
These results suggest that beta-agonists, at low concentrations, predominantly inhibit IL-4 production and may therefore act as anti-inflammatory drugs in allergic asthma.
Gene_expression (production) of IL-4 associated with asthma, inflammation, cinod and agonist
8) Confidence 0.73 Published 1996 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8796447 Disease Relevance 0.20 Pain Relevance 0.27
ASA inhibited IL-4, but not IL-2, promoter-driven chloramphenicol acetyltransferase expression in transiently transfected Jurkat T cells.
Gene_expression (expression) of IL-4 in T cells
9) Confidence 0.69 Published 2001 Journal Blood Section Abstract Doc Link 11238116 Disease Relevance 0.09 Pain Relevance 0.30
It is concluded that anti-inflammatory salicylates, by means of a previously unrecognized mechanism of action, can influence the nature of adaptive immune responses by selectively inhibiting the expression of IL-4, a critical effector of these responses, in CD4+ T cells.
Gene_expression (expression) of IL-4 in T cells associated with inflammation
10) Confidence 0.69 Published 2001 Journal Blood Section Abstract Doc Link 11238116 Disease Relevance 0.17 Pain Relevance 0.19
Selective inhibition of interleukin-4 gene expression in human T cells by aspirin.
Gene_expression (expression) of interleukin-4 in T cells associated with aspirin
11) Confidence 0.69 Published 2001 Journal Blood Section Title Doc Link 11238116 Disease Relevance 0.07 Pain Relevance 0.35
The structurally unrelated nonsteroidal anti-inflammatory drugs indomethacin and flurbiprofen did not affect cytokine gene expression in T cells, whereas the weak cyclo-oxygenase inhibitor salicylic acid was at least as effective as ASA in inhibiting IL-4 expression and promoter activity.
Gene_expression (expression) of IL-4 in T cells associated with inflammation, cinod and cytokine
12) Confidence 0.69 Published 2001 Journal Blood Section Abstract Doc Link 11238116 Disease Relevance 0.16 Pain Relevance 0.32
Dextrorphan significantly enhanced, pentazocine, haloperidol and phencyclidine had no effect, while SKF 10 047 suppressed production of IL-4.
Gene_expression (production) of IL-4 associated with fortral
13) Confidence 0.68 Published 2005 Journal Georgian Med News Section Abstract Doc Link 16308450 Disease Relevance 0.07 Pain Relevance 0.30
Spontaneous secretion of IL-4 and IL-8 correlates with synthesis of nitric oxide, suggesting that NO and transitory S-nitrosylation of up-stream proteins participate in the sigma ligand dependent expression of IL-4 and IL-8 genes.
Gene_expression (expression) of IL-4
14) Confidence 0.68 Published 2005 Journal Georgian Med News Section Abstract Doc Link 16308450 Disease Relevance 0.06 Pain Relevance 0.27
We have found, that pentazocine, SKF 10 047, dextrorphan reduce spontaneous secretion of IL-8, IL-6 and IL-10 and selectively changes synthesis of IL-4 by Jurkat human T lymphocyte cells lines.
Gene_expression (synthesis) of IL-4 in T lymphocyte associated with fortral
15) Confidence 0.68 Published 2005 Journal Georgian Med News Section Abstract Doc Link 16308450 Disease Relevance 0.08 Pain Relevance 0.32
Besides its immunoregulatory effects, interleukin-4 (IL-4) has growth inhibitory activity on cells from human solid tumors, and IL-4 receptors are present on tumor cells including cells from head and neck squamous cell carcinomas.
Gene_expression (present) of IL-4 in neck associated with cancer, solid tumor and skin cancer
16) Confidence 0.68 Published 2005 Journal Oncol. Rep. Section Abstract Doc Link 15706415 Disease Relevance 0.63 Pain Relevance 0
Besides its immunoregulatory effects, interleukin-4 (IL-4) has growth inhibitory activity on cells from human solid tumors, and IL-4 receptors are present on tumor cells including cells from head and neck squamous cell carcinomas.
Gene_expression (present) of IL-4 in neck associated with cancer, solid tumor and skin cancer
17) Confidence 0.68 Published 2005 Journal Oncol. Rep. Section Abstract Doc Link 15706415 Disease Relevance 0.63 Pain Relevance 0
Besides its immunoregulatory effects, interleukin-4 (IL-4) has growth inhibitory activity on cells from human solid tumors, and IL-4 receptors are present on tumor cells including cells from head and neck squamous cell carcinomas.
Gene_expression (present) of interleukin-4 in neck associated with cancer, solid tumor and skin cancer
18) Confidence 0.68 Published 2005 Journal Oncol. Rep. Section Abstract Doc Link 15706415 Disease Relevance 0.63 Pain Relevance 0
For IL-4 determination, murine IL4 Eli-pair kit (Diaclone Research, Besancon, France) were used according to the manufacturer's recommendations and absorbance was measured at 450 nm.


Gene_expression (used) of IL4
19) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 0 Pain Relevance 0.04
Pitrakinra is a recombinant IL-4 variant that competitively antagonises the IL-4R?
Gene_expression (antagonises) of IL-4
20) Confidence 0.65 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2820465 Disease Relevance 0.16 Pain Relevance 0.04

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