INT56299

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Context Info
Confidence 0.64
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 10.20
Pain Relevance 5.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL4) extracellular region (IL4)
Anatomy Link Frequency
T cell 2
joint 1
middle ear 1
lungs 1
optic 1
IL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 354 100.00 Very High Very High Very High
cytokine 325 100.00 Very High Very High Very High
chemokine 38 100.00 Very High Very High Very High
Neuritis 2 99.96 Very High Very High Very High
Multiple sclerosis 12 99.58 Very High Very High Very High
cINOD 14 98.24 Very High Very High Very High
rheumatoid arthritis 216 97.72 Very High Very High Very High
dexamethasone 45 94.12 High High
Osteoarthritis 64 91.92 High High
tolerance 8 86.88 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 360 100.00 Very High Very High Very High
Optic Neuritis 2 99.96 Very High Very High Very High
Eosinophilia 53 99.60 Very High Very High Very High
Demyelinating Disease 12 99.58 Very High Very High Very High
Reprotox - General 3 27 99.36 Very High Very High Very High
Disease 270 98.38 Very High Very High Very High
Asthma 390 98.20 Very High Very High Very High
Neurological Disease 2 98.04 Very High Very High Very High
Rheumatoid Arthritis 218 97.72 Very High Very High Very High
Otitis Media With Effusion 39 95.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibitory effect of ASA on IL-4 transcription was not mediated by decreased nuclear expression of the known salicylate target nuclear factor (NF)-kappaB and was accompanied by reduced binding of an inducible factor to an IL-4 promoter region upstream of, but not overlapping, the NF of activated T cells- and NF-kappaB-binding P1 element.
Transcription (transcription) of IL-4 in T cells
1) Confidence 0.64 Published 2001 Journal Blood Section Abstract Doc Link 11238116 Disease Relevance 0.16 Pain Relevance 0.31
The expression pattern of IL4, IL10 and TGF® mRNA levels was analyzed following peptide-specific stimulation.
Transcription (levels) of IL4
2) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765612 Disease Relevance 0.29 Pain Relevance 0.16
In MS and optic neuritis, IL-4 mRNA expressing cells predominated, followed by TGF-beta- and IFN-gamma-positive cells.
Transcription (expressing) of IL-4 in optic associated with multiple sclerosis, optic neuritis and neuritis
3) Confidence 0.39 Published 1994 Journal Ann. Neurol. Section Abstract Doc Link 8080246 Disease Relevance 1.16 Pain Relevance 0.79
In similar studies, montelukast decreases IL-4 mRNA expression in the lungs while increasing IFN-?
Transcription (expression) of IL-4 in lungs
4) Confidence 0.31 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.79 Pain Relevance 0.41
In contrast, NSAIDs down-regulated IL-6 production both at the mRNA and protein levels, and down-regulated IL-4 mRNA expression.
Transcription (expression) of IL-4 associated with cinod
5) Confidence 0.21 Published 1995 Journal Cytokine Section Abstract Doc Link 8589268 Disease Relevance 0.31 Pain Relevance 0.60
Likewise, drastically reduced synthesis of IL-4 and IL-10 mRNA by synovial fluid mononuclear cells from RA patients correlates with disease activity [46].
Transcription (synthesis) of IL-4 in mononuclear cells associated with rheumatoid arthritis and disease
6) Confidence 0.19 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.72 Pain Relevance 0.27
IL-4 levels and IL-13 levels were below detection limits in non-stimulated serum as well as in ACS (Figure 5).


Transcription (levels) of IL-4
7) Confidence 0.12 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911907 Disease Relevance 0.32 Pain Relevance 0.44
Similarly, Smimova et al. (22) reported that the mucin content of effusions was correlated with the concentration of IL-4 and IL-13, suggesting the involvement of IL-4 and IL-13 in the upregulation of middle ear mucin metabolism.
Transcription (concentration) of IL-4 in middle ear
8) Confidence 0.11 Published 2010 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2896736 Disease Relevance 1.02 Pain Relevance 0.09
Glucocorticoids, the most effective agents for reducing eosinophilia, suppress the gene transcription of IL-3, IL-4, IL-5, GM-CSF, and various chemokines [1].
Transcription (transcription) of IL-4 associated with chemokine and eosinophilia
9) Confidence 0.11 Published 2004 Journal Clin Mol Allergy Section Body Doc Link PMC425596 Disease Relevance 0.54 Pain Relevance 0.10
We have also studied cytokines associated with the function of Th2 (IL-4 and IL-10) and Th1 (IL-2, IL-12 (p70), and INF?)
Transcription (function) of IL-4 associated with cytokine
10) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991033 Disease Relevance 1.12 Pain Relevance 0.75
Higher levels of IL-4 and IL-10 mRNA within a joint are allied with a milder oligoarticular course and non-erosive disease67).
Transcription (levels) of IL-4 in joint
11) Confidence 0.07 Published 2010 Journal Korean Journal of Pediatrics Section Body Doc Link PMC3012271 Disease Relevance 0.87 Pain Relevance 0.42
Although the glucocorticoid action in inflammatory diseases is not fully understood, it is well documented that glucocorticoids inhibit the transcription of the majority of inflammatory cytokines and chemokines involved in the inflammatory process, including eotaxin, GM-CSF, IL-1ß, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8, IL-11, MCP-1, MIP-1, MIP-3, MIP-4, MIP-1?
Transcription (transcription) of IL-4 associated with chemokine, inflammation, disease and cytokine
12) Confidence 0.05 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 1.28 Pain Relevance 0.56
In the same cohort of patients, we also showed increased IL-5 and IL-4 mRNA-positive cells in the small airways of asthmatic persons as compared with nonasthmatic control individuals (Fig. 4) [5].
Transcription (showed) of IL-4 associated with asthma
13) Confidence 0.04 Published 2001 Journal Respir Res Section Body Doc Link PMC64806 Disease Relevance 0.67 Pain Relevance 0.08
The sequential events include induction of CD 80/86 on the B cell that engages CD28 on the T cell, leading to transcription of pivotal Th2 cytokines IL-4 and/or IL-13.
Transcription (transcription) of IL-4 in T cell associated with cytokine
14) Confidence 0.03 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2837605 Disease Relevance 0 Pain Relevance 0.17
In our study, IL-4 was undetectable and IL-13 levels were not significantly different in any group in contrast to previous report in which cHSP60 specific IL-13 in PBMCs has been reported to be associated with the protective response [22].
Transcription (undetectable) of IL-4
15) Confidence 0.02 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2412883 Disease Relevance 0.96 Pain Relevance 0.29

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