INT5630

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Context Info
Confidence 0.45
First Reported 1992
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 5.21
Pain Relevance 11.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pdpk1) cytoplasmic membrane-bounded vesicle (Pdpk1) plasma membrane (Pdpk1)
nucleus (Pdpk1) kinase activity (Pdpk1) cytoplasm (Pdpk1)
Anatomy Link Frequency
paw 3
neuronal 1
neurons 1
brain 1
dorsal horn 1
Pdpk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 36 100.00 Very High Very High Very High
withdrawal 14 100.00 Very High Very High Very High
addiction 11 99.80 Very High Very High Very High
Hyperalgesia 21 99.66 Very High Very High Very High
tolerance 9 99.50 Very High Very High Very High
spinal dorsal horn 1 99.36 Very High Very High Very High
Morphine 17 99.30 Very High Very High Very High
Neuropathic pain 6 99.10 Very High Very High Very High
Inflammation 44 98.92 Very High Very High Very High
Pain 7 98.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 27 99.66 Very High Very High Very High
Diabetes Mellitus 8 99.40 Very High Very High Very High
Neuropathic Pain 6 99.10 Very High Very High Very High
INFLAMMATION 34 98.92 Very High Very High Very High
Morphine Dependence 2 97.78 Very High Very High Very High
Nervous System Injury 1 81.44 Quite High
Complex Regional Pain Syndromes 1 80.16 Quite High
Diabetic Nephropathy 1 77.80 Quite High
Pain 5 68.84 Quite High
Opiate Addiction 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A defined mixture of purified gangliosides, which inhibits intracellular protein kinase C translocation and activation, decreased inflammation-induced paw withdrawal latency, and specifically decreased the activity of membrane-associated protein kinase Cbetall on the side of the spinal cord ipsilateral to the inflammation.
Localization (translocation) of protein kinase in paw associated with kinase c, inflammation, withdrawal and spinal cord
1) Confidence 0.45 Published 2001 Journal Neuroscience Section Abstract Doc Link 11440817 Disease Relevance 1.02 Pain Relevance 1.29
Importantly, on the side of lumbar cord ipsilateral to the inflamed paw, the activity of membrane-associated protein kinase CbetaII was increased following the same time-course as the paw withdrawal latency decrease, suggesting an increased translocation of protein kinase Cbetall to the membrane related to behavioral hyperalgesia.
Localization (translocation) of protein kinase in paw associated with hyperalgesia and withdrawal
2) Confidence 0.45 Published 2001 Journal Neuroscience Section Abstract Doc Link 11440817 Disease Relevance 1.02 Pain Relevance 1.30
This finding suggests that DA activates protein kinase C in cultured striatal cells, because increases in [3H]PdBu binding reflect translocation of protein kinase C.
Localization (translocation) of protein kinase associated with kinase c and dopamine
3) Confidence 0.43 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1312574 Disease Relevance 0 Pain Relevance 0.63
Importantly, on the side of lumbar cord ipsilateral to the inflamed paw, the activity of membrane-associated protein kinase CbetaII was increased following the same time-course as the paw withdrawal latency decrease, suggesting an increased translocation of protein kinase Cbetall to the membrane related to behavioral hyperalgesia.
Localization (translocation) of protein kinase in paw associated with hyperalgesia and withdrawal
4) Confidence 0.36 Published 2001 Journal Neuroscience Section Abstract Doc Link 11440817 Disease Relevance 1.06 Pain Relevance 1.35
The data provide evidence that a common molecular event that converges to initiate and maintain hyperalgesia may include the translocation and activation of protein kinase CbetaII in the spinal dorsal horn.
Localization (translocation) of protein kinase in dorsal horn associated with hyperalgesia and spinal dorsal horn
5) Confidence 0.27 Published 2006 Journal Neuroscience Section Abstract Doc Link 16360284 Disease Relevance 0.45 Pain Relevance 0.50
The general protein kinase inhibitor H-7, augments [3H]NE release in both brain regions and may have additive effects with GABA in cortical slices.
Localization (release) of protein kinase in brain associated with gaba
6) Confidence 0.17 Published 2001 Journal Neurochem. Res. Section Abstract Doc Link 11565619 Disease Relevance 0 Pain Relevance 1.06
The development of tolerance to the analgesic effects of morphine as well as morphine dependence were greatly reduced by co-administration with morphine of GM1 ganglioside, a substance reported to block the translocation of protein kinase C (PKC) from cytosol to membrane of neurons.
Localization (translocation) of protein kinase in neurons associated with addiction, kinase c, analgesic, tolerance and morphine
7) Confidence 0.16 Published 1995 Journal Pain Section Abstract Doc Link 7478679 Disease Relevance 0.10 Pain Relevance 1.45
The development of morphine tolerance and dependence is associated with translocation of protein kinase C.
Localization (translocation) of protein kinase associated with addiction, kinase c, tolerance and morphine
8) Confidence 0.16 Published 1995 Journal Pain Section Title Doc Link 7478679 Disease Relevance 0.10 Pain Relevance 1.54
Diabetes alters neuronal nitric oxide release from rat mesenteric arteries.
Localization (release) of protein kinase in neuronal associated with diabetes mellitus
9) Confidence 0.15 Published 2000 Journal Life Sci. Section Title Doc Link 10665985 Disease Relevance 0.54 Pain Relevance 0.25
The association of neuropathic pain, morphine tolerance and dependence, and the translocation of protein kinase C.
Localization (translocation) of protein kinase associated with pain, addiction, kinase c, tolerance, neuropathic pain and morphine
10) Confidence 0.05 Published 1995 Journal NIDA Res. Monogr. Section Title Doc Link 8742791 Disease Relevance 0.93 Pain Relevance 2.00

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