INT56300

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Context Info
Confidence 0.41
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 4.87
Pain Relevance 3.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TGFB1) enzyme binding (TGFB1) embryo development (TGFB1)
cytoplasm (TGFB1) extracellular space (TGFB1) extracellular region (TGFB1)
Anatomy Link Frequency
periosteum 2
TMJ 2
epithelial cells 2
adult mouse 1
TGFB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 6 100.00 Very High Very High Very High
dexamethasone 9 99.98 Very High Very High Very High
Multiple sclerosis 11 99.66 Very High Very High Very High
Osteoarthritis 17 99.42 Very High Very High Very High
Snapping jaw 5 99.12 Very High Very High Very High
Opioid 8 99.06 Very High Very High Very High
aspirin 100 92.84 High High
Mechanotransduction 16 92.28 High High
Pain 7 88.72 High High
cytokine 15 87.88 High High
Disease Link Frequency Relevance Heat
Demyelinating Disease 11 99.66 Very High Very High Very High
Disease 13 99.52 Very High Very High Very High
Osteoarthritis 19 99.42 Very High Very High Very High
Temporomandibular Joint Syndrome 5 99.12 Very High Very High Very High
Endometriosis (extended) 2 97.00 Very High Very High Very High
Cardiovascular Disease 3 96.48 Very High Very High Very High
Cancer 96 95.36 Very High Very High Very High
INFLAMMATION 44 87.48 High High
Aging 1 86.76 High High
Stress 4 86.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, but the highest level of expression of TGF-?
Negative_regulation (level) of Gene_expression (expression) of TGF
1) Confidence 0.41 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165041 Disease Relevance 0.12 Pain Relevance 0.07
We hypothesized that a balance between IL-1beta and TGFbeta underlies the development of TMJ osteoarthritis, whereby IL-1beta signaling down-regulates TGFbeta expression as part of disease pathology.
Negative_regulation (down-regulates) of Gene_expression (expression) of TGFbeta in TMJ associated with snapping jaw, disease and osteoarthritis
2) Confidence 0.40 Published 2009 Journal J. Dent. Res. Section Abstract Doc Link 19587162 Disease Relevance 1.20 Pain Relevance 0.76
IFN-gamma and TGF-beta may have opposing effects in MS, and treatments inhibiting IFN-gamma and/or promoting TGF-beta might ameliorate MS.
Negative_regulation (inhibiting) of Gene_expression (promoting) of TGF-beta associated with multiple sclerosis
3) Confidence 0.40 Published 1994 Journal Ann. Neurol. Section Abstract Doc Link 8080246 Disease Relevance 1.05 Pain Relevance 0.61
In fact, after the priming of estradiol, the expression of transforming growth factor beta1 (TGF-?
Negative_regulation (priming) of Gene_expression (expression) of transforming growth factor beta1
4) Confidence 0.40 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1262771 Disease Relevance 0.58 Pain Relevance 0.25
We have found that kappa opioids exerted a time- and dose-dependent inhibitory effect on TGFbeta1 production from endometrial stromal and epithelial cells and from the Ishikawa human endometrial adenocarcinoma cell line.
Negative_regulation (effect) of Gene_expression (production) of TGFbeta1 in epithelial cells associated with endometriosis (extended) and opioid
5) Confidence 0.39 Published 2000 Journal Mol. Hum. Reprod. Section Abstract Doc Link 10871647 Disease Relevance 0.10 Pain Relevance 0.72
The application of both TGF-beta1 and dexamethasone resulted in an additional effect on fibronectin; however, dexamethasone inhibited the TGF-beta1-induced NGF expression.
Negative_regulation (inhibited) of Gene_expression (expression) of TGF-beta1-induced associated with nerve growth factor and dexamethasone
6) Confidence 0.37 Published 2007 Journal J Endod Section Abstract Doc Link 17931932 Disease Relevance 0.15 Pain Relevance 0.72
As shown in Fig. 2, a significant stimulating effect of TGF-?
Negative_regulation (shown) of Gene_expression (effect) of TGF
7) Confidence 0.35 Published 2006 Journal J Orthop Surg Section Body Doc Link PMC1636034 Disease Relevance 0 Pain Relevance 0
Inhibitors were: anti-TGF-?
Negative_regulation (Inhibitors) of Gene_expression (anti) of TGF
8) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842433 Disease Relevance 0 Pain Relevance 0.18
In addition, production of growth factors (TGFbeta, BMP-2 and BMP-4) in the lining was largely prevented but production of these growth factors in deeper layers of the synovium and the periosteum did not differ from controls.
Negative_regulation (prevented) of Gene_expression (production) of TGFbeta in periosteum
9) Confidence 0.24 Published 2004 Journal Osteoarthr. Cartil. Section Body Doc Link 15262242 Disease Relevance 0.14 Pain Relevance 0
Moreover, Slug interacted with the L1CAM promoter, and its knockdown abrogated the TGF-beta1- and PMF-induced L1CAM expression.
Negative_regulation (abrogated) of Gene_expression (expression) of TGF-beta1
10) Confidence 0.13 Published 2009 Journal Cancer Res. Section Abstract Doc Link 19435915 Disease Relevance 0.68 Pain Relevance 0.07
Inhibition of ROCK in the presence of exogenous TGF
Negative_regulation (Inhibition) of Gene_expression (presence) of TGF
11) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.19 Pain Relevance 0.04
In another study, transfection of HSCs with a dominant negative form of Rho inhibited the increased production of TGF-ß induced by mechanical stretch [53].
Negative_regulation (inhibited) of Gene_expression (production) of TGF
12) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.45 Pain Relevance 0.05
Even though the TGF-?
Negative_regulation (Even) of Gene_expression (though) of TGF
13) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0.22 Pain Relevance 0.03
-responsive cell cycle inhibitors in the adult mouse lung, including p15, p<span style="background-color:#FFFF00">21, and p57, and inhibit</span>ed TGF-?
Negative_regulation (inhibitors) of Gene_expression (expression) of transforming growth factor-beta in adult mouse
14) Confidence 0.03 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0

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