INT56301

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Context Info
Confidence 0.56
First Reported 1994
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 68
Total Number 74
Disease Relevance 54.51
Pain Relevance 18.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL4) extracellular region (IL4)
Anatomy Link Frequency
T cells 6
blood 2
nasal 2
peritoneal fluid 2
apoptotic cell 1
IL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1448 100.00 Very High Very High Very High
Inflammation 1410 99.98 Very High Very High Very High
Inflammatory response 129 99.92 Very High Very High Very High
Crohn's disease 61 99.64 Very High Very High Very High
opioid receptor 20 99.52 Very High Very High Very High
rheumatoid arthritis 704 99.48 Very High Very High Very High
aspirin 62 99.42 Very High Very High Very High
Cannabinoid 43 99.36 Very High Very High Very High
substance P 48 99.32 Very High Very High Very High
lidocaine 4 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1587 99.98 Very High Very High Very High
Infection 509 99.92 Very High Very High Very High
Common Cold 90 99.92 Very High Very High Very High
Eosinophilia 100 99.90 Very High Very High Very High
Influenza Virus Infection 48 99.82 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 361 99.66 Very High Very High Very High
Immune Reconstitution Inflammatory Syndrome 1554 99.64 Very High Very High Very High
Disease 738 99.64 Very High Very High Very High
Cancer 583 99.56 Very High Very High Very High
Hypersensitivity 134 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and tumor necrosis factor alpha production without induction of IL-4 [30].
Neg (without) Positive_regulation (induction) of IL-4 associated with necrosis and cancer
1) Confidence 0.56 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.94 Pain Relevance 0.31
With respect to the increase of IL-4, the combination was significantly additive to the effect of either IL-7 or IL-4 alone.


Positive_regulation (increase) of IL-4
2) Confidence 0.56 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.36 Pain Relevance 0.18
On the contrary, induction of IL-4 was even more pronounced for RA patients than for healthy controls.
Positive_regulation (induction) of IL-4 associated with rheumatoid arthritis
3) Confidence 0.56 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.45 Pain Relevance 0.22
We could observe that PKA is involved in IL-4 mediated PPE mRNA induction, whereas IL-10 apparently uses another route.
Positive_regulation (induction) of IL-4
4) Confidence 0.51 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9357452 Disease Relevance 0 Pain Relevance 0.42
Increased transforming growth factor-beta, interleukin-4, and interferon-gamma in multiple sclerosis.
Positive_regulation (Increased) of interleukin-4 associated with multiple sclerosis
5) Confidence 0.51 Published 1994 Journal Ann. Neurol. Section Title Doc Link 8080246 Disease Relevance 0.91 Pain Relevance 0.62
For anti-inflammatory molecules and esophagitis risk, Khurana Hershey et al. demonstrated that IL4R:rs1801275 resulted in enhanced IL4 signaling and the induction of high levels of the IgE receptor CD23 [25].
Positive_regulation (enhanced) of IL4 associated with esophageal disease and inflammation
6) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928273 Disease Relevance 0.78 Pain Relevance 0.20
Thus, systemically acting neuroendocrine peptides such as ACTH and locally acting neuropeptides such as the enkephalins and substance P can modulate the magnitude of an IL-4 induced IgE response.
Positive_regulation (induced) of IL-4 associated with neuropeptide, enkephalin and substance p
7) Confidence 0.44 Published 1996 Journal Exp. Dermatol. Section Abstract Doc Link 8624610 Disease Relevance 0 Pain Relevance 0.56
In this report we show that stimulation with interleukin-4 induces mu-opioid receptor transcripts in human primary blood cells (T cells and polymorphonuclear leukocytes), immune cell lines (Raji, U-937, and HMEC-1), and dendritic cells.
Positive_regulation (stimulation) of interleukin-4 in immune cell associated with opioid receptor
8) Confidence 0.43 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11572871 Disease Relevance 0 Pain Relevance 0.32
It has been shown in humans [22,23] and in mice [24,25] that, in an autocrine way, the initial endogenous IL-4 production, or IL-4 from other sources, can stimulate the development of IL-4-producing CD4+ T cells.
Positive_regulation (stimulate) of IL-4 in T cells
9) Confidence 0.40 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.26 Pain Relevance 0.18
We show that interleukin-4 is transcriptionally induced in response to cannabinoids and that an interleukin-4 receptor antagonist blocks cannabinoid-dependent induction of mu-opioid receptors, indicating that induced expression of interleukin-4 is required in this process.
Positive_regulation (induced) of interleukin-4 associated with antagonist, cannabinoid and mu opioid receptor
10) Confidence 0.39 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16434616 Disease Relevance 0 Pain Relevance 0.77
Induction of interleukin-4 is blocked by decoy oligonucleotides directed against STAT5, indicating the requirement of this transcription factor.
Positive_regulation (Induction) of interleukin-4
11) Confidence 0.39 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16434616 Disease Relevance 0 Pain Relevance 0.79
Furthermore, it was found that during this period IL-7, but not IL-4, is a soluble factor for early IL-4 induction in naive CD4+ T cells in (adult) RA patients, which has also been described for human neonatal naive CD4+ T cells [27].
Positive_regulation (induction) of IL-4 in T cells associated with rheumatoid arthritis
12) Confidence 0.37 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.60 Pain Relevance 0.30
Most important, with respect to IL-4 induction, there was no lack in responsiveness to IL-7, to IL-4 or to their combination in RA patients compared with in healthy controls.
Positive_regulation (induction) of IL-4 associated with rheumatoid arthritis
13) Confidence 0.37 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.40 Pain Relevance 0.20
In line with earlier studies [22,26], we found that a relatively short activation period (the first 5 days of culture) of naive CD4+CD45RA+ T cells from RA patients through the TCR/CD3 complex together with CD28 costimulation by itself induces IL-4.
Positive_regulation (induces) of IL-4 in T cells associated with rheumatoid arthritis
14) Confidence 0.37 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.56 Pain Relevance 0.31
Furthermore, it was found that during this period IL-7, but not IL-4, is a soluble factor for early IL-4 induction in naive CD4+ T cells in (adult) RA patients, which has also been described for human neonatal naive CD4+ T cells [27].
Positive_regulation (induction) of IL-4 in T cells associated with rheumatoid arthritis
15) Confidence 0.37 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.59 Pain Relevance 0.30
Swelling was associated with high levels of TNF-alpha, IFN-gamma, and IL-4 (P < 0.05).
Positive_regulation (levels) of IL-4
16) Confidence 0.34 Published 2010 Journal J. Oral Pathol. Med. Section Body Doc Link 20102461 Disease Relevance 0 Pain Relevance 0
Patients with tenderness showed significantly higher levels of IFN-gamma and IL-4 (P < 0.05).
Positive_regulation (levels) of IL-4
17) Confidence 0.34 Published 2010 Journal J. Oral Pathol. Med. Section Body Doc Link 20102461 Disease Relevance 0 Pain Relevance 0
PGE2 primes naive T cells in a dose-dependent fashion for production of high levels of IL-4, IL-10 and IL-13, and very low levels of IL-2, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, and TNF-beta.
Positive_regulation (levels) of IL-4 in naive T cells associated with necrosis and cancer
18) Confidence 0.33 Published 1997 Journal Eur. J. Immunol. Section Abstract Doc Link 9464843 Disease Relevance 0.79 Pain Relevance 0.55
Aspirin and salicylates inhibit the IL-4- and IL-13-induced activation of STAT6.
Positive_regulation (activation) of IL-4 associated with aspirin
19) Confidence 0.32 Published 2002 Journal J. Immunol. Section Title Doc Link 11801685 Disease Relevance 0.74 Pain Relevance 0.30
Similarly, no statistical difference was found between control and CD for the TGF® and IL4 induction (not shown).
Positive_regulation (induction) of IL4 associated with crohn's disease
20) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765612 Disease Relevance 0.50 Pain Relevance 0.30

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