INT56309

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Context Info
Confidence 0.39
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 8.47
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Baat) peroxisome (Baat) transferase activity, transferring acyl groups (Baat)
lipid metabolic process (Baat) cytoplasm (Baat)
Anatomy Link Frequency
neurons 1
brain 1
BAT 1
pollen 1
Basophil 1
Baat (Mus musculus)
Pain Link Frequency Relevance Heat
Raphe 9 98.88 Very High Very High Very High
Catecholamine 2 98.48 Very High Very High Very High
diclofenac 280 96.20 Very High Very High Very High
imagery 23 95.12 Very High Very High Very High
Eae 23 94.08 High High
positron emission tomography 48 88.20 High High
IPN 1 69.52 Quite High
tolerance 8 59.32 Quite High
cINOD 68 34.72 Quite Low
Inflammation 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 363 100.00 Very High Very High Very High
Hypoxia 126 99.84 Very High Very High Very High
Hypersensitivity 56 99.32 Very High Very High Very High
Body Weight 82 96.72 Very High Very High Very High
Targeted Disruption 80 88.00 High High
Apnoea 28 87.36 High High
Disease 7 86.64 High High
Infection 9 86.16 High High
Weight Loss 18 80.48 Quite High
Overweight 2 80.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The activation of BAT has been evidenced to play an important role in energy expenditure [47].
Positive_regulation (activation) of BAT associated with obesity
1) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 0.82 Pain Relevance 0.27
BAT function can be stimulated by hypoxia [9].
Positive_regulation (stimulated) of BAT in BAT associated with hypoxia and obesity
2) Confidence 0.35 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2970595 Disease Relevance 2.59 Pain Relevance 0.05
BAT activation occurs at room temperatures between 4 - 16°C [9,13,21-23].
Positive_regulation (activation) of BAT associated with obesity
3) Confidence 0.30 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2970595 Disease Relevance 1.93 Pain Relevance 0
The weight of interscapular BAT was increased (p<0.001) in leptin-deficient mice (wild type 0.31±0.02, ob/ob 0.80±0.04 g/100 g body weight).
Positive_regulation (increased) of BAT in body associated with body weight and obesity
4) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 1.59 Pain Relevance 0.03
It should be noted that the POA insulin doses used give rise to POA insulin concentrations that are in the range of circulating plasma concentrations of insulin and are unlikely to exert the BAT effects via leakage to other brain areas or to the periphery.
Positive_regulation (exert) of BAT in brain associated with obesity
5) Confidence 0.12 Published 2010 Journal Diabetes Section Body Doc Link PMC2797943 Disease Relevance 0.61 Pain Relevance 0.03
Rats are known to have a relatively large amount of BAT in the interscapular region and thus are often used in research for BAT activation (11).
Positive_regulation (activation) of BAT associated with obesity
6) Confidence 0.12 Published 2010 Journal Diabetes Section Body Doc Link PMC2797943 Disease Relevance 0.20 Pain Relevance 0.35
Retrograde tracing indicates that insulin receptor–expressing warm-sensitive neurons activate BAT through projection via the raphe pallidus.
Positive_regulation (activate) of BAT in neurons associated with obesity and raphe
7) Confidence 0.12 Published 2010 Journal Diabetes Section Abstract Doc Link PMC2797943 Disease Relevance 0.41 Pain Relevance 0.21
Basophil activation test (BAT)
Positive_regulation (activation) of BAT in Basophil
8) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965666 Disease Relevance 0.05 Pain Relevance 0.06
In fact, we observed that basophils from birch-allergic donors collected off-season were reactive in BAT, but the corresponding pollen-specific serum IgE was negative or borderline when determined by ELISA (data not shown).
Positive_regulation (reactive) of BAT in pollen associated with hypersensitivity
9) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965666 Disease Relevance 0.27 Pain Relevance 0.44
Using a high level Escherichia coli expression system for the Penicillium chrysogenum penDE gene, we have produced acyl-coenzyme A: isopenicillin N acyltransferase (AT) enzymes containing amino acid substitutions at three conserved Ser residues.
Positive_regulation (produced) of N acyltransferase
10) Confidence 0.01 Published 1994 Journal FEMS Microbiol. Lett. Section Abstract Doc Link 8082826 Disease Relevance 0 Pain Relevance 0.07

General Comments

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