INT56310

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Context Info
Confidence 0.44
First Reported 1994
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 17
Disease Relevance 15.50
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Baat) peroxisome (Baat) transferase activity, transferring acyl groups (Baat)
lipid metabolic process (Baat) cytoplasm (Baat)
Anatomy Link Frequency
BAT 2
body 2
liver 1
Mouse 1
immune system 1
Baat (Mus musculus)
Pain Link Frequency Relevance Heat
diclofenac 140 98.86 Very High Very High Very High
tolerance 77 91.80 High High
Catecholamine 1 90.16 High High
Eae 25 88.60 High High
agonist 32 86.08 High High
IPN 1 69.52 Quite High
Glutamate 14 59.40 Quite High
cINOD 34 35.84 Quite Low
anesthesia 16 20.80 Low Low
cerebral cortex 8 20.44 Low Low
Disease Link Frequency Relevance Heat
Obesity 1166 100.00 Very High Very High Very High
Diabetes Mellitus 44 99.36 Very High Very High Very High
Hyperlipidemia 10 98.80 Very High Very High Very High
Apnoea 14 94.84 High High
Impaired Glucose Tolerance 61 91.80 High High
Targeted Disruption 126 91.44 High High
Overweight 8 87.92 High High
Hypersensitivity 28 86.52 High High
Hypoxia 63 86.24 High High
Body Weight 193 85.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BAT produces heat through the action of uncoupling protein 1 (UCP1) [6].
Gene_expression (produces) of BAT in BAT associated with obesity
1) Confidence 0.44 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2970595 Disease Relevance 2.19 Pain Relevance 0.05
Immunohistological analyses showed a high expression of Ucp-1 and Ucp-3 in BAT in all experimental groups.
Gene_expression (expression) of BAT associated with obesity
2) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 1.44 Pain Relevance 0
We measured BAT UCP1 expression to determine if the increased BAT glucose uptake may lead to increased thermogenesis.
Gene_expression (expression) of BAT
3) Confidence 0.35 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.29 Pain Relevance 0.03
However, there was no significant difference in UCP1 mRNA expression of BAT among the four groups in this study.
Gene_expression (expression) of BAT associated with obesity
4) Confidence 0.33 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.20 Pain Relevance 0.07
There were no significant differences in UCP-1 mRNA expression of BAT among the four groups (Fig. 3A).
Gene_expression (expression) of BAT associated with obesity
5) Confidence 0.33 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.26 Pain Relevance 0.04
Previous studies have reported a “white-like” appearance of BAT in ob/ob mice, suggesting a crucial role of leptin in the development of brown adipocytes [22].
Gene_expression (appearance) of BAT in adipocytes associated with obesity
6) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 0.83 Pain Relevance 0.25
It has been proposed that leptin-deficient mice show higher food efficiency rates at least in part due to an impaired capacity of BAT to produce heat [2], [41].
Gene_expression (produce) of BAT associated with obesity
7) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 1.59 Pain Relevance 0
UCP1 expression in BAT is also known as a significant component of whole body energy expenditure and its dysfunction contributes to the development of obesity [15].
Gene_expression (expression) of BAT in body associated with obesity
8) Confidence 0.33 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.11 Pain Relevance 0.05
In contrast to liver-UCP2, there was no change in BAT-UCP1 mRNA expression in HFD-fed GhrR KO mice (Figure 6B).


Gene_expression (expression) of BAT in liver
9) Confidence 0.31 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.27 Pain Relevance 0
In the current study, BAT UCP1 mRNA expression was unaffected by genotype in HFD-fed mice, which indicated that diet-induced thermogenesis was not impacted by the loss of ghrelin signaling.


Gene_expression (expression) of BAT
10) Confidence 0.31 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0 Pain Relevance 0
UCP-1 expression in BAT is known to be a significant component of whole body energy expenditure and its dysfunction contributes to the development of obesity [15].
Gene_expression (expression) of BAT in body associated with obesity
11) Confidence 0.29 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.82 Pain Relevance 0.11
Mouse BAT and epididymal WAT were taken and stored in an Isogen solution (Nippon Gene Co., Ltd., Tokyo, Japan).
Gene_expression (taken) of BAT in Mouse associated with obesity
12) Confidence 0.29 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 0.46 Pain Relevance 0
mRNA expression of UCP1 and UCP2 in WAT and BAT
Gene_expression (expression) of BAT associated with obesity
13) Confidence 0.29 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.33 Pain Relevance 0.03
There were no significant differences in UCP1 mRNA expression of BAT among the four groups.
Gene_expression (expression) of BAT in BAT associated with obesity
14) Confidence 0.26 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Abstract Doc Link PMC2266052 Disease Relevance 1.27 Pain Relevance 0.03
Actin primer-probe set (Applied Biosystems) was included in a separate well and used to normalize the soleus, BAT, and heart gene expression data.
Gene_expression (normalize) of BAT in heart associated with obesity
15) Confidence 0.24 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064854 Disease Relevance 0.18 Pain Relevance 0
As basophils have been recently shown to be key players in the immune system [32], we investigated DF/DF5der/DF-metabolite-specific IgE bound on patients' basophils by BAT and sLT production.
Gene_expression (production) of BAT in immune system associated with diclofenac
16) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965666 Disease Relevance 0.27 Pain Relevance 0.39
Using a high level Escherichia coli expression system for the Penicillium chrysogenum penDE gene, we have produced acyl-coenzyme A: isopenicillin N acyltransferase (AT) enzymes containing amino acid substitutions at three conserved Ser residues.
Gene_expression (produced) of N acyltransferase
17) Confidence 0.01 Published 1994 Journal FEMS Microbiol. Lett. Section Abstract Doc Link 8082826 Disease Relevance 0 Pain Relevance 0.07

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