INT56337

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Context Info
Confidence 0.27
First Reported 1994
Last Reported 2008
Negated 4
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 1.09
Pain Relevance 2.33

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oxidoreductase activity (Cyp1a2) endoplasmic reticulum (Cyp1a2) enzyme binding (Cyp1a2)
response to stress (Cyp1a2)
Anatomy Link Frequency
plasma 1
2B7 1
Cyp1a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 14 98.38 Very High Very High Very High
sSRI 20 98.14 Very High Very High Very High
Onset of action 1 96.32 Very High Very High Very High
Paracetamol 4 95.64 Very High Very High Very High
Desipramine 2 94.20 High High
Morphine 3 93.68 High High
antidepressant 13 86.08 High High
Serotonin 3 82.88 Quite High
tricyclic antidepressant 4 68.96 Quite High
depression 3 55.52 Quite High
Disease Link Frequency Relevance Heat
Nicotine Addiction 6 93.84 High High
Serotonin Syndrome 1 83.24 Quite High
Xerostomia 1 80.32 Quite High
Sleep Disorders 1 79.44 Quite High
Body Weight 1 76.24 Quite High
Hepatotoxicity 4 65.92 Quite High
Hyperuricemia 31 60.08 Quite High
Crystal Associated Disease 54 58.64 Quite High
Depression 3 55.52 Quite High
Disease 4 40.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data are consistent with the hypothesis that omeprazole is generally devoid of inducing effects on CYP1A2 activity in vivo, at least in a Caucasian population with a low prevalence of the omeprazole-mephenytoin poor metabolizer phenotype.
Regulation (effects) of CYP1A2
1) Confidence 0.27 Published 1994 Journal Ther Drug Monit Section Abstract Doc Link 8085279 Disease Relevance 0 Pain Relevance 0.17
Effects of cytochrome P450 isoforms, CYP1A2, CYP2C9 and CYP3A4, on the catalytic activity of UDP-glucuronosyltransferase 2B7 (UGT2B7) expressed in COS cell microsomal membranes were investigated using morphine as a substrate.
Spec (investigated) Regulation (Effects) of CYP1A2 in 2B7 associated with morphine
2) Confidence 0.23 Published 2005 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16204972 Disease Relevance 0 Pain Relevance 0.23
Based on the in vitro study that showed febuxostat had a weak inhibitory effect on CYP2D6, but no effect on CYP1A2, CYP2C9, CYP2C19 or CYP3A4, Khosravan et al (2005b) examined the effect of multiple doses of febuxostat 120 mg daily on the pharmacokinetics of desipramine, a substrate for CYP2D6.
Neg (no) Regulation (effect) of CYP1A2 associated with desipramine
3) Confidence 0.22 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643102 Disease Relevance 0.24 Pain Relevance 0.09
These results demonstrated that, in contrast to results found in previous studies, Chinese subjects were fully susceptible to the inducing effect of cigarette smoke on CYP1A2 activity.
Regulation (effect) of CYP1A2
4) Confidence 0.15 Published 1998 Journal Ther Drug Monit Section Abstract Doc Link 9712458 Disease Relevance 0.47 Pain Relevance 0.16
The cytochrome (CYP) P450 isoenzymes CYP1A2, CYP2D6, and CYP3A4 are mainly responsible for its metabolism.
Regulation (responsible) of CYP1A2
5) Confidence 0.15 Published 2001 Journal CNS Drug Rev Section Abstract Doc Link 11607047 Disease Relevance 0.29 Pain Relevance 0.28
Within the group of SSRIs, fluoxetine and paroxetine are potent inhibitors of CYP2D6, while fluvoxamine predominantly affects CYP1A2 and CYP2C19 activity.
Regulation (affects) of CYP1A2 associated with ssri and fluoxetine
6) Confidence 0.14 Published 2002 Journal Drugs Aging Section Abstract Doc Link 12038880 Disease Relevance 0.08 Pain Relevance 0.55
The CYP1A2, CYP2C9, CYP2C19, CYP3A5, and UGT2B7 genotypes did not influence methadone plasma levels.
Neg (not) Regulation (influence) of CYP1A2 in plasma
7) Confidence 0.07 Published 2006 Journal Clin. Pharmacol. Ther. Section Body Doc Link 17178267 Disease Relevance 0 Pain Relevance 0
Sertraline produces mild inhibition of CYP2D6 but has little, if any, effect on CYP1A2, CYP2C9/10, CYP2C19 or CYP3A3/4.
Neg (little) Regulation (effect) of CYP1A2
8) Confidence 0.06 Published 1997 Journal Clin Pharmacokinet Section Abstract Doc Link 9068931 Disease Relevance 0 Pain Relevance 0.42
Sertraline produces mild inhibition of CYP2D6 but has little, if any, effect on CYP1A2, CYP2C9/10, CYP2C19 or CYP3A3/4.
Neg (little) Regulation (has) of CYP1A2
9) Confidence 0.06 Published 1997 Journal Clin Pharmacokinet Section Abstract Doc Link 9068931 Disease Relevance 0 Pain Relevance 0.42

General Comments

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