INT56342

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Context Info
Confidence 0.78
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 34
Total Number 35
Disease Relevance 16.50
Pain Relevance 2.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (TTR) extracellular space (TTR) extracellular region (TTR)
cytoplasm (TTR)
Anatomy Link Frequency
liver 3
plasma 2
epithelium 1
SCO 1
TTR (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 107 99.24 Very High Very High Very High
cINOD 103 98.98 Very High Very High Very High
Multiple sclerosis 12 93.88 High High
carpal tunnel syndrome 7 93.04 High High
cva 82 92.76 High High
anesthesia 4 91.28 High High
cOX1 13 89.76 High High
peripheral neuropathy 9 88.92 High High
headache 9 86.88 High High
Potency 58 58.00 Quite High
Disease Link Frequency Relevance Heat
Amyloidosis 209 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 23 100.00 Very High Very High Very High
Cancer 13 99.98 Very High Very High Very High
Targeted Disruption 22 99.92 Very High Very High Very High
Neuromyelitis Optica 162 99.68 Very High Very High Very High
Alzheimer's Dementia 378 99.52 Very High Very High Very High
Familial Amyloidotic Polyneuropathy 120 99.36 Very High Very High Very High
INFLAMMATION 125 99.24 Very High Very High Very High
Adhesions 4 99.16 Very High Very High Very High
Disease 173 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most common hereditary amyloidogenic protein, transthyretin, is synthesized in the liver and lies on Chromosome 18.
Gene_expression (synthesized) of transthyretin in liver
1) Confidence 0.78 Published 2008 Journal J Med Case Reports Section Abstract Doc Link PMC2248590 Disease Relevance 0.83 Pain Relevance 0
Transthyretin expression of the present case further supports the likelihood of SCO origin, as transthyretin is one of the proteins presumed to be secreted by human SCO.
Gene_expression (expression) of Transthyretin in SCO
2) Confidence 0.77 Published 2004 Journal Acta Neuropathol. Section Abstract Doc Link 15221340 Disease Relevance 0.67 Pain Relevance 0.07
The tumor expressed abundant levels of transthyretin (prealbumin) and appeared ependymal in nature, with numerous microlumens delineated by punctate and ring-like patterns in epithelial membrane antigen staining.
Gene_expression (expressed) of transthyretin associated with cancer
3) Confidence 0.77 Published 2004 Journal Acta Neuropathol. Section Abstract Doc Link 15221340 Disease Relevance 0.79 Pain Relevance 0.09
Synthesis of TTR fibrillogenesis inhibitors
Gene_expression (Synthesis) of TTR
4) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607018 Disease Relevance 0.06 Pain Relevance 0
The prognosis changed after the implementation of orthotropic liver transplantation as a treatment strategy which halts the synthesis of amyloidogenic transthyretin.
Gene_expression (synthesis) of transthyretin in liver
5) Confidence 0.68 Published 2008 Journal J Med Case Reports Section Abstract Doc Link PMC2248590 Disease Relevance 1.15 Pain Relevance 0
Direct DNA sequencing revealed both the normal TTT (phenylalanine) and a new variant TCT (serine) at position 44 of the TTR gene.
Gene_expression (position) of TTR gene
6) Confidence 0.68 Published 1998 Journal Neurology Section Abstract Doc Link 9818883 Disease Relevance 0.65 Pain Relevance 0.24
DNA analysis of the TTR gene revealed a point mutation responsible for substitution of valine for isoleucine at position 107 of the TTR molecule.
Gene_expression (position) of TTR molecule
7) Confidence 0.68 Published 2002 Journal J. Neurol. Sci. Section Abstract Doc Link 12039669 Disease Relevance 0.97 Pain Relevance 0.18
Analogues of diflunisal, an FDA-approved nonsteroidal antiinflammatory drug (NSAID), were synthesized and evaluated as inhibitors of transthyretin (TTR) aggregation, including amyloid fibril formation.
Gene_expression (aggregation) of transthyretin associated with inflammation, alzheimer's dementia and cinod
8) Confidence 0.67 Published 2004 Journal J. Med. Chem. Section Abstract Doc Link 14711308 Disease Relevance 0.20 Pain Relevance 0.10
Analogues of diflunisal, an FDA-approved nonsteroidal antiinflammatory drug (NSAID), were synthesized and evaluated as inhibitors of transthyretin (TTR) aggregation, including amyloid fibril formation.
Gene_expression (aggregation) of TTR associated with inflammation, alzheimer's dementia and cinod
9) Confidence 0.67 Published 2004 Journal J. Med. Chem. Section Abstract Doc Link 14711308 Disease Relevance 0.20 Pain Relevance 0.10
This is specially crucial in this case because very strong plasma protein competitors of TTR include thyroid binding globulin (TBG), which has an order of magnitude high affinity for thyroxine [60], and albumin (ALB) which is at concentrations of two orders of magnitude higher than TTR in plasma.
Gene_expression (include) of TTR in plasma
10) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607018 Disease Relevance 0.33 Pain Relevance 0
To analyze the pathologic processes of amyloid deposition in type I familial amyloidotic polyneuropathy (FAP), mice were made transgenic by introducing the human mutant transthyretin (TTR) gene(MT-hMet 30).
Gene_expression (introducing) of TTR associated with targeted disruption, familial amyloidotic polyneuropathy, pathologic processes and alzheimer's dementia
11) Confidence 0.65 Published 1994 Journal Mol. Neurobiol. Section Abstract Doc Link 8086125 Disease Relevance 1.27 Pain Relevance 0.09
Mass spectrometric analyses of TTR immunoprecipitated from serum showed the presence of both wild-type and variant proteins.
Gene_expression (presence) of TTR
12) Confidence 0.60 Published 2007 Journal Amyloid Section Abstract Doc Link 17453626 Disease Relevance 0.48 Pain Relevance 0.10
Plasma glutathione peroxidase, similar to complement component 3 and chain A of transthyretin (TTR) were under-expressed in the sera of the AS patients.
Gene_expression (expressed) of TTR in Plasma
13) Confidence 0.58 Published 2010 Journal Clin. Exp. Rheumatol. Section Body Doc Link 20483041 Disease Relevance 0.13 Pain Relevance 0
Computational GRID studies of TTR binding site and molecular modeling on TTR complexes
Gene_expression (complexes) of TTR
14) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607018 Disease Relevance 0.30 Pain Relevance 0
Crystal structures of TTR of two new complexes of TTR with diflunisal analogs (23b and 22b)
Gene_expression (structures) of TTR
15) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607018 Disease Relevance 0.12 Pain Relevance 0.03
Accordingly, the aim of the present investigation was to provide initial evidences for the hypothesis that iodine atom addition to already known TTR inhibitors could produce more potent TTR fibrillogenesis inhibitors (hereafter referred to as the iodination hypothesis).
Gene_expression (produce) of TTR
16) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607018 Disease Relevance 0.16 Pain Relevance 0
To analyze the pathologic processes of amyloid deposition in type I familial amyloidotic polyneuropathy (FAP), mice were made transgenic by introducing the human mutant transthyretin (TTR) gene(MT-hMet 30).
Gene_expression (introducing) of mutant transthyretin associated with targeted disruption, familial amyloidotic polyneuropathy, pathologic processes and alzheimer's dementia
17) Confidence 0.51 Published 1994 Journal Mol. Neurobiol. Section Abstract Doc Link 8086125 Disease Relevance 1.27 Pain Relevance 0.09
The TTR?
Gene_expression (The) of TTR
18) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709434 Disease Relevance 0 Pain Relevance 0
The overall molecular structure of the TTR?
Gene_expression (structure) of TTR
19) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709434 Disease Relevance 0 Pain Relevance 0.03
Specifically, we suggested that the bulkier substituents projecting into the HBP1 and HBP2 regions of the TTR?
Gene_expression (regions) of TTR
20) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709434 Disease Relevance 0.22 Pain Relevance 0.16

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