INT56364

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Context Info
Confidence 0.61
First Reported 1994
Last Reported 2010
Negated 5
Speculated 5
Reported most in Abstract
Documents 19
Total Number 24
Disease Relevance 9.82
Pain Relevance 5.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGAM) plasma membrane (ITGAM)
Anatomy Link Frequency
neutrophils 20
granulocyte 8
DCs 4
macrophages 3
blood 2
ITGAM (Homo sapiens)
Pain Link Frequency Relevance Heat
local anesthetic 17 100.00 Very High Very High Very High
lidocaine 14 100.00 Very High Very High Very High
Opioid 10 100.00 Very High Very High Very High
Inflammation 182 99.08 Very High Very High Very High
cINOD 12 98.36 Very High Very High Very High
Enkephalin 6 97.28 Very High Very High Very High
analgesia 4 96.36 Very High Very High Very High
corticosteroid 21 82.36 Quite High
Inflammatory response 25 81.72 Quite High
Nicotine 182 81.44 Quite High
Disease Link Frequency Relevance Heat
Nicotine Addiction 302 100.00 Very High Very High Very High
Adhesions 151 100.00 Very High Very High Very High
Bacterial Respiratory Disease 1 100.00 Very High Very High Very High
Disease 65 99.54 Very High Very High Very High
INFLAMMATION 227 99.08 Very High Very High Very High
Cv Unclassified Under Development 12 98.76 Very High Very High Very High
Hypoxia 1 98.40 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 32 97.60 Very High Very High Very High
Pulmonary Disease 18 92.92 High High
Asthma 23 92.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of this study was to investigate anti-inflammatory properties of ropivacaine with regard to its effects on the expression and function of CD11b in human neutrophils.
Regulation (effects) of Gene_expression (expression) of CD11b in neutrophils associated with inflammation
1) Confidence 0.61 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20348036 Disease Relevance 0.35 Pain Relevance 0.37
However, ropivacaine showed no effect on the fMLP-induced CD11b expression in the presence of butan-1-ol, a blocker of phospholipase D (PLD) pathway, which completely inhibited the fMLP-induced CD11b expression in neutrophils.
Neg (no) Regulation (effect) of Gene_expression (expression) of CD11b in neutrophils
2) Confidence 0.61 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20348036 Disease Relevance 0.37 Pain Relevance 0.25
Ropivacaine exerted a time-dependent effect on CD11b expression only (24% +/- 34%; P < .05).
Regulation (effect) of Gene_expression (expression) of CD11b
3) Confidence 0.61 Published 2008 Journal Reg Anesth Pain Med Section Body Doc Link 18675739 Disease Relevance 0 Pain Relevance 0
Thus, we studied the effects of Lido on canine granulocyte CD11b expression and ROS production.
Regulation (effects) of Gene_expression (expression) of CD11b in granulocyte
4) Confidence 0.53 Published 2010 Journal J. Vet. Med. Sci. Section Abstract Doc Link 19940395 Disease Relevance 0.09 Pain Relevance 0.25
To assess the effect of opioid peptides on CD11a, CD11b, CD18 and CD16 molecule expression the whole blood samples were incubated with different concentrations of the opioids, then the white cells were labelled with respective PE-conjugated MoAb and evaluated by flow cytometry.
Regulation (effect) of Gene_expression (expression) of CD11b in blood associated with opioid
5) Confidence 0.49 Published 1999 Journal Immunol. Lett. Section Abstract Doc Link 10232386 Disease Relevance 0.15 Pain Relevance 0.92
However, effects of newer local anesthetics like bupivacaine and ropivacaine on antibacterial host defense-primarily phagocytosis activity, oxidative burst, or CD11b expression-still remain unclear.
Regulation (effects) of Gene_expression (expression-still) of CD11b associated with bacterial respiratory disease and local anesthetic
6) Confidence 0.45 Published 2003 Journal Anesthesiology Section Abstract Doc Link 12657844 Disease Relevance 0.10 Pain Relevance 0.27
However, ropivacaine showed no effect on the fMLP-induced CD11b expression in the presence of butan-1-ol, a blocker of phospholipase D (PLD) pathway, which completely inhibited the fMLP-induced CD11b expression in neutrophils.
Neg (no) Regulation (effect) of Gene_expression (expression) of CD11b in neutrophils
7) Confidence 0.45 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20348036 Disease Relevance 0.38 Pain Relevance 0.25
All nonsteroidal antiinflammatory drugs (NSAIDs) inhibit neutrophil aggregation (homotypic cell-cell adhesion) and do so without affecting expression of CD11b/CD18.
Neg (without) Regulation (affecting) of Gene_expression (expression) of CD11b in neutrophil associated with inflammation, cinod and adhesions
8) Confidence 0.44 Published 1994 Journal Inflammation Section Abstract Doc Link 8088928 Disease Relevance 0.61 Pain Relevance 0.34
The evaluation of exposed macrophages in the white pulp area with anti-CD11b monoclonal antibody
Regulation (evaluation) of Gene_expression (antibody) of CD11b in macrophages
9) Confidence 0.44 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998779 Disease Relevance 0 Pain Relevance 0
METHODS: Using flow cytometric assay of whole human blood, we investigated direct effects of endogenous and synthetic opioid peptides on surface expression of complement receptors CD35 and CD11b/CD18 and Fcã receptor III CD16, and superoxide anion generation of neutrophils.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of CD11b in neutrophils
10) Confidence 0.44 Published 2003 Journal Br J Anaesth Section Body Doc Link 14504158 Disease Relevance 0.10 Pain Relevance 0
We further studied the effects of Lido on the priming of canine granulocyte CD11b expression and ROS production by recombinant canine granulocyte macrophage colony stimulating factor (rcGM-CSF).
Regulation (effects) of Gene_expression (expression) of CD11b in granulocyte
11) Confidence 0.39 Published 2010 Journal J. Vet. Med. Sci. Section Abstract Doc Link 19940395 Disease Relevance 0.09 Pain Relevance 0.24
Effects of lidocaine hydrochloride on canine granulocytes, granulocyte CD11b expression and reactive oxygen species production.
Regulation (hydrochloride) of in granulocytes Gene_expression (expression) of CD11b in granulocyte associated with lidocaine
12) Confidence 0.39 Published 2010 Journal J. Vet. Med. Sci. Section Title Doc Link 19940395 Disease Relevance 0.09 Pain Relevance 0.29
Effects of ropivacaine on adhesion molecule CD11b expression and function in human neutrophils.
Regulation (Effects) of Gene_expression (expression) of CD11b in neutrophils associated with adhesions
13) Confidence 0.27 Published 2010 Journal Int. Immunopharmacol. Section Title Doc Link 20348036 Disease Relevance 0.42 Pain Relevance 0.38
We hypothesized that local anesthetics have time-dependent effects on phagocytosis of S. aureus, oxidative burst, and CD11b expression by human neutrophils.
Regulation (effects) of Gene_expression (expression) of CD11b in neutrophils
14) Confidence 0.27 Published 2008 Journal Reg Anesth Pain Med Section Abstract Doc Link 18675739 Disease Relevance 0.18 Pain Relevance 0.30
The effect of lidocaine on neutrophil CD11b/CD18 and endothelial ICAM-1 expression and IL-1beta concentrations induced by hypoxia-reoxygenation.
Regulation (effect) of Gene_expression (expression) of CD11b in neutrophil associated with hypoxia and lidocaine
15) Confidence 0.26 Published 2004 Journal Eur J Anaesthesiol Section Title Doc Link 15719860 Disease Relevance 0.10 Pain Relevance 0.20
We have previously examined the influence of tobacco smoking on CD11b expression, and other adhesion molecules, on circulating human neutrophils in vivo [27,28].
Spec (examined) Regulation (influence) of Gene_expression (expression) of CD11b in neutrophils associated with nicotine addiction and adhesions
16) Confidence 0.21 Published 2008 Journal BMC Cell Biol Section Body Doc Link PMC2375863 Disease Relevance 0.95 Pain Relevance 0.14
Given the importance that monocytes, macrophages, and DCs likely have in the pathophysiology of O3-induced exacerbations of disease, we also examined the effect of these treatments on expression of CD11b/CR3, mCD14, CD16/Fc?
Spec (examined) Regulation (effect) of Gene_expression (expression) of CD11b in DCs associated with disease
17) Confidence 0.17 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0.62 Pain Relevance 0.13
We found that tobacco smoking did not acutely influence CD11b expression levels on primary neutrophils.
Neg (not) Regulation (influence) of Gene_expression (expression) of CD11b in neutrophils associated with nicotine addiction
18) Confidence 0.16 Published 2008 Journal BMC Cell Biol Section Body Doc Link PMC2375863 Disease Relevance 1.00 Pain Relevance 0.13
Changes in the cell surface expression of CD62L and CD11b following tourniquet-applied upper limb orthopaedic surgery is associated with cell activation.
Regulation (Changes) of Gene_expression (expression) of CD11b in upper limb
19) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.61 Pain Relevance 0.07
Effects of lidocaine hydrochloride on canine granulocytes, granulocyte CD11b expression and reactive oxygen species production.
Regulation (hydrochloride) of Gene_expression (expression) of CD11b in granulocyte associated with lidocaine
20) Confidence 0.13 Published 2010 Journal J. Vet. Med. Sci. Section Title Doc Link 19940395 Disease Relevance 0.09 Pain Relevance 0.29

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