INT56365

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Context Info
Confidence 0.60
First Reported 1994
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 3.87
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGB2) plasma membrane (ITGB2) cell-cell signaling (ITGB2)
Anatomy Link Frequency
neutrophils 6
sputum 2
blood 2
ITGB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 10 100.00 Very High Very High Very High
cINOD 8 98.36 Very High Very High Very High
Inflammation 51 97.44 Very High Very High Very High
Enkephalin 6 97.28 Very High Very High Very High
adenocard 11 75.00 Quite High
chemokine 2 52.96 Quite High
cytokine 16 51.28 Quite High
Potency 1 34.80 Quite Low
Inflammatory response 6 28.48 Quite Low
Nicotine 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 100 99.60 Very High Very High Very High
Nicotine Addiction 183 99.32 Very High Very High Very High
INFLAMMATION 62 98.08 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 22 97.60 Very High Very High Very High
Asthma 51 94.32 High High
Hypersensitivity 28 73.72 Quite High
Stress 2 73.60 Quite High
Airway Obstruction 2 56.12 Quite High
Disease 36 46.12 Quite Low
Eosinophilia 1 36.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All nonsteroidal antiinflammatory drugs (NSAIDs) inhibit neutrophil aggregation (homotypic cell-cell adhesion) and do so without affecting expression of CD11b/CD18.
Neg (without) Regulation (affecting) of Gene_expression (expression) of CD18 in neutrophil associated with inflammation, cinod and adhesions
1) Confidence 0.60 Published 1994 Journal Inflammation Section Abstract Doc Link 8088928 Disease Relevance 0.61 Pain Relevance 0.35
Tyrosine kinase inhibitors prevented the effect of indomethacin on Mac-1 expression and Ca2+ mobilization.
Regulation (effect) of Gene_expression (expression) of Mac-1
2) Confidence 0.44 Published 1997 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9218092 Disease Relevance 0 Pain Relevance 0
AIMS: To investigate whether indomethacin modulates: (1) Mac-1 expression; (2) Ca2+ mobilization ([Ca2+]i), protein kinase C and nitric oxide accumulation; and (3) mitogen-associated protein kinase phosphorylation in human PMN.
Spec (whether) Regulation (modulates) of Gene_expression (expression) of Mac-1 in PMN
3) Confidence 0.38 Published 1997 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9218092 Disease Relevance 0 Pain Relevance 0
To assess the effect of opioid peptides on CD11a, CD11b, CD18 and CD16 molecule expression the whole blood samples were incubated with different concentrations of the opioids, then the white cells were labelled with respective PE-conjugated MoAb and evaluated by flow cytometry.
Regulation (effect) of Gene_expression (expression) of CD18 in blood associated with opioid
4) Confidence 0.37 Published 1999 Journal Immunol. Lett. Section Abstract Doc Link 10232386 Disease Relevance 0.15 Pain Relevance 0.92
METHODS: Using flow cytometric assay of whole human blood, we investigated direct effects of endogenous and synthetic opioid peptides on surface expression of complement receptors CD35 and CD11b/CD18 and Fcã receptor III CD16, and superoxide anion generation of neutrophils.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of CD18 in neutrophils
5) Confidence 0.26 Published 2003 Journal Br J Anaesth Section Body Doc Link 14504158 Disease Relevance 0.10 Pain Relevance 0
It is also possible that smoking may not affect all smokers equally, and that a differential effect on CD18/CD11b expression could discriminate smokers at increased risk of developing COPD.
Regulation (effect) of Gene_expression (expression) of CD18 associated with nicotine addiction and chronic obstructive pulmonary disease
6) Confidence 0.14 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 2.27 Pain Relevance 0
The allergen-induced levels of beta-chain mRNA and CCR3 mRNA in sputum-derived cells were inhibited by TPIASM8, but no significant effects on cell surface protein expression of CCR3 and the beta-chain were found.
Neg (no) Regulation (effects) of Gene_expression (expression) of beta-chain in sputum
7) Confidence 0.01 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.74 Pain Relevance 0.09

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