INT56368

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Context Info
Confidence 0.75
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 3.76
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hspa1a) mitochondrion (Hspa1a) nucleus (Hspa1a)
intracellular (Hspa1a) protein complex (Hspa1a) cytoplasm (Hspa1a)
Anatomy Link Frequency
neurons 1
arterioles 1
cleavage 1
trachea 1
body 1
Hspa1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn neuron 2 99.98 Very High Very High Very High
Dynorphin 1 97.90 Very High Very High Very High
Spinal cord 49 97.72 Very High Very High Very High
ischemia 20 97.24 Very High Very High Very High
aspirin 14 96.84 Very High Very High Very High
Inflammation 7 96.56 Very High Very High Very High
qutenza 4 89.84 High High
cINOD 2 88.52 High High
substance P 2 84.32 Quite High
Lasting pain 3 71.32 Quite High
Disease Link Frequency Relevance Heat
Shock 2 100.00 Very High Very High Very High
Fever 7 98.44 Very High Very High Very High
Apoptosis 12 98.00 Very High Very High Very High
Spinal Cord Ischemia 15 97.72 Very High Very High Very High
Reperfusion Injury 3 96.84 Very High Very High Very High
Neurogenic Inflammation 5 96.56 Very High Very High Very High
Stress 4 93.48 High High
Injury 14 92.24 High High
Pressure Volume 2 Under Development 1 91.68 High High
INFLAMMATION 4 88.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
According to pharmacology of TMP and studies for effects of TMP on cerebral ischemic injury, antiplatelet activation and aggregation, dilating arterioles to improve microcirculation [17,18], scavenging free radicals, increasing the activity of SOD and decreasing lipid peroxidation [10], inhibiting calcium overload [9], reducing the production of nitric oxide and dynorphin A1-13 in ischemic tissue [19,20], decreasing the protein expression of c-fos and increasing the protein expression of bcl-2 and heat shock protein 70(HSP 70) [21,22]may be mechanisms for protection of TMP against spinal cord ischemia /reperfusion injury.
Gene_expression (expression) of HSP 70 in arterioles associated with reperfusion injury, dynorphin, ischemia, shock, injury and spinal cord
1) Confidence 0.75 Published 2002 Journal BMC Neurol Section Body Doc Link PMC107739 Disease Relevance 0.86 Pain Relevance 0.39
RT-PCR and Western blotting techniques were used to analyze mRNA and protein expression of HSP72 and HSP90 and cleavage of caspase 3 protein.
Spec (analyze) Gene_expression (expression) of HSP72 in cleavage
2) Confidence 0.72 Published 2000 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 10859212 Disease Relevance 0.74 Pain Relevance 0.27
Western blotting analysis showed that the expression of heat shock protein 72 (HSP 72) in the trachea on days 1 and 2 after hyperthermia was 9.61-fold and 6.66-fold, respectively, of that in normothermia.
Gene_expression (expression) of HSP 72 in trachea associated with shock and fever
3) Confidence 0.59 Published 2010 Journal Auton Neurosci Section Abstract Doc Link 20138590 Disease Relevance 1.20 Pain Relevance 0.57
HSP72 mRNA and protein expression was unchanged in adapted mucosa, whereas HSP90 mRNA and protein levels decreased.
Gene_expression (expression) of HSP72
4) Confidence 0.56 Published 2000 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 10859212 Disease Relevance 0.76 Pain Relevance 0.31
RESULTS: EA significantly decreased the pancreatic weight/body weight ratio in CCK-induced acute pancreatitis, increased the pancreatic levels of HSP60 and HSP72, and decreased the beta-amylase and lipase levels associated with CCK-induced acute pancreatitis.
Gene_expression (levels) of HSP72 in body
5) Confidence 0.52 Published 2007 Journal Neuroimmunomodulation Section Body Doc Link 17804915 Disease Relevance 0.07 Pain Relevance 0
These slow negative potentials probably reflect the activities of dorsal horn neurons producing the HSP1 and HSP2, respectively, also elicited by a feedback loop via supraspinal structures.
Gene_expression (producing) of HSP1 in neurons associated with dorsal horn neuron
6) Confidence 0.11 Published 1994 Journal J Clin Neurophysiol Section Abstract Doc Link 8089206 Disease Relevance 0.06 Pain Relevance 0.23
These slow positive potentials (HSP1 and HSP2) might be produced by a feedback loop via supraspinal structures, presumably primary afferent depolarizations, in comparison to the HSPs of our previous studies in the rat.
Gene_expression (produced) of HSP1
7) Confidence 0.11 Published 1994 Journal J Clin Neurophysiol Section Abstract Doc Link 8089206 Disease Relevance 0.07 Pain Relevance 0.29

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