INT56379

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Context Info
Confidence 0.55
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 9
Disease Relevance 7.16
Pain Relevance 9.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
paw 1
nociceptors 1
microglia 1
urine 1
Syt17 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
B1 receptor 297 100.00 Very High Very High Very High
bradykinin 124 100.00 Very High Very High Very High
agonist 35 100.00 Very High Very High Very High
b2 receptor 6 100.00 Very High Very High Very High
nociceptor 9 99.92 Very High Very High Very High
noradrenaline 6 99.82 Very High Very High Very High
c fibre 25 99.68 Very High Very High Very High
Brush evoked pain 39 99.62 Very High Very High Very High
Thermal hyperalgesia 24 99.18 Very High Very High Very High
Inflammation 38 97.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 195 99.68 Very High Very High Very High
Neuropathic Pain 194 99.62 Very High Very High Very High
Hyperalgesia 65 99.18 Very High Very High Very High
Pressure And Volume Under Development 9 99.02 Very High Very High Very High
INFLAMMATION 48 97.64 Very High Very High Very High
Diuresis 2 92.96 High High
Natriuresis 4 91.12 High High
Hyperglycemia 24 86.96 High High
Ganglion Cysts 8 85.28 High High
Nociception 26 84.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BK-alpha mRNA increased threefold, and BK-alpha protein increased fivefold from 3 days to 6 wk.
Positive_regulation (increased) of BK-alpha protein
1) Confidence 0.55 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17234952 Disease Relevance 0 Pain Relevance 0.26
It is concluded that NA-induced augmentation of the BK actions occurred by activating alpha 2-adrenergic receptor.
Positive_regulation (augmentation) of BK associated with noradrenaline and bradykinin
2) Confidence 0.54 Published 2007 Journal Kokubyo Gakkai Zasshi Section Abstract Doc Link 17682457 Disease Relevance 0.55 Pain Relevance 1.33
Bradykinin (BK) and Tyr8-BK induced graded rat paw edema with EC50 values of 1.9 and 1.1 nmol/paw, while des-Arg9-BK (DABK, up to 300 nmol/paw) was marginally effective.
Positive_regulation (effective) of des-Arg9-BK in paw associated with pressure and volume under development and bradykinin
3) Confidence 0.42 Published 1995 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8846414 Disease Relevance 0.56 Pain Relevance 0.52
Degradation of bradykinin (BK) to BK-(1-8) in rat urine was completely inhibited by EB (10(-5) M) with the increased generation of BK-(1-7).
Positive_regulation (increased) of BK in urine associated with bradykinin
4) Confidence 0.34 Published 1994 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 8089934 Disease Relevance 0.26 Pain Relevance 0.28
We conclude that in chronically inflamed tissue, sensitivity of C-fiber nociceptors to BK, which is B2 receptor mediated, is strongly increased and that B1 receptor may not be important to a persistent inflammatory state, at least at the primary afferent level.
Positive_regulation (increased) of BK in nociceptors associated with c fibre, inflammation, b1 receptor, nociceptor, b2 receptor and bradykinin
5) Confidence 0.19 Published 2001 Journal J. Neurophysiol. Section Abstract Doc Link 11731532 Disease Relevance 0.17 Pain Relevance 1.87
The results show that A. australis garzonii scorpion toxin stimulates NPY release from both rat atria and kidneys, and suggest that the toxin induces NPY release via BK stimulation through B2 receptors.
Positive_regulation (stimulation) of BK
6) Confidence 0.10 Published 2009 Journal Peptides Section Abstract Doc Link 19433126 Disease Relevance 0 Pain Relevance 0.50
The B1R is activated by the active metabolites des-Arg9-BK and Lys-des-Arg9-BK and has a low level of expression in healthy tissues [10].
Positive_regulation (activated) of Lys-des-Arg9-BK associated with b1 receptor and bradykinin
7) Confidence 0.04 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 2.15 Pain Relevance 1.49
The B1R is activated by the active metabolites des-Arg9-BK and Lys-des-Arg9-BK and has a low level of expression in healthy tissues [10].
Positive_regulation (activated) of des-Arg9-BK associated with b1 receptor and bradykinin
8) Confidence 0.04 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 2.13 Pain Relevance 1.47
The specific objectives were to: 1) determine whether microglia inhibitors can prevent thermal hyperalgesia and tactile allodynia induced by spinal activation of B1R with the selective agonist des-Arg9-BK in STZ-diabetic rats; 2) compare the acute inhibition of B1R and microglial function on tactile and cold allodynia; 3) determine the effect of microglia inhibition on the expression of B1R and pro-inflammatory markers (IL-1?
Positive_regulation (activation) of des-Arg9-BK in microglia associated with brush evoked pain, allodynia, diabetes mellitus, bradykinin, thermal hyperalgesia, b1 receptor, inflammatory marker and agonist
9) Confidence 0.04 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 1.34 Pain Relevance 1.33

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