INT56385

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Context Info
Confidence 0.22
First Reported 1994
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 11
Total Number 14
Disease Relevance 15.07
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gk) histone binding (Gk) nucleus (Gk)
carbohydrate metabolic process (Gk) cytoplasm (Gk)
Anatomy Link Frequency
myocardium 1
pancreatic islets 1
aorta 1
cardiomyocyte 1
connective tissue 1
Gk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
lidocaine 9 99.84 Very High Very High Very High
fibrosis 112 93.52 High High
Inflammation 24 92.88 High High
Bioavailability 12 80.08 Quite High
ischemia 8 74.44 Quite High
antiarrhythmic agent 1 67.08 Quite High
anesthesia 28 5.00 Very Low Very Low Very Low
imagery 19 5.00 Very Low Very Low Very Low
ketamine 8 5.00 Very Low Very Low Very Low
Perioperative pain 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 692 100.00 Very High Very High Very High
Myocardial Infarction 624 100.00 Very High Very High Very High
Apoptosis 345 98.36 Very High Very High Very High
Stress 77 95.60 Very High Very High Very High
Coronary Heart Disease 84 95.12 Very High Very High Very High
Hyperglycemia 56 94.84 High High
Fibrosis 96 93.52 High High
INFLAMMATION 24 92.88 High High
Metabolic Disorder 1 91.84 High High
Hypertrophy 112 86.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By dihydroethidine fluorescence staining, we determined that aorta superoxide levels were significantly elevated in 9 month-old GK compared with age matched Wistar (GK; 195±6%, Wistar; 100±3.5%).
Positive_regulation (elevated) of GK in aorta
1) Confidence 0.22 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2909910 Disease Relevance 0.49 Pain Relevance 0.04
Kitahara et.al reported that G6PD activity is significantly elevated in GK rat liver and we have observed similar increases in the myocardium from the Zucker fa/fa rat [51], [54].
Positive_regulation (elevated) of GK in myocardium
2) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909910 Disease Relevance 0.28 Pain Relevance 0
Chronic hyperglycemia did not increased expression of several components of the NAD(P)H oxidase system and this was observed at both the protein and mRNA levels These results are similar to the Zucker fa/fa/rat (type 2) but differ from that observed by Bitnar et.al who observed increases in p47phox in younger GK rats [8], [51], [52].
Positive_regulation (increases) of GK associated with hyperglycemia
3) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909910 Disease Relevance 0.52 Pain Relevance 0
In GK rats, MI induced an increase in PTEN protein expression, reduced Akt phosphorylation and a concomitant decrease in FOXO3a phosphorylation which might have contributed to the increase in cardiomyocyte apoptosis seen here.
Positive_regulation (induced) of GK in cardiomyocyte associated with apoptosis and myocardial infarction
4) Confidence 0.15 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.36 Pain Relevance 0.11
In the present study we showed a tendency for IL-6 and CTGF mRNA expressions to be increased after MI in diabetic GK rats.
Positive_regulation (increased) of GK associated with diabetes mellitus and myocardial infarction
5) Confidence 0.15 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.40 Pain Relevance 0.14
In the present study we found that MI did not increase Akt phosphorylation in GK rats.
Neg (not) Positive_regulation (increase) of GK associated with myocardial infarction
6) Confidence 0.15 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.04 Pain Relevance 0.04
Interstitial collagen volume fraction measured from the remote area was increased in GK rats with MI compared to non-diabetic Wistar rats with MI (Figure 4).


Positive_regulation (increased) of GK associated with diabetes mellitus and myocardial infarction
7) Confidence 0.15 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 2.12 Pain Relevance 0.03
PTEN phosphatase expression was slightly increased after MI in GK rats which might explain the decrease in Akt kinase phosphorylation level.
Positive_regulation (increased) of GK associated with myocardial infarction
8) Confidence 0.15 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 0.99 Pain Relevance 0.04
TUNEL analysis showed that the number of apoptotic nuclei, measured from the border zone and in the area remote to the infarct, was higher in GK rats after MI as compared to Wistar controls (Figure 3).
Positive_regulation (higher) of GK associated with apoptosis and myocardial infarction
9) Confidence 0.15 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 2.13 Pain Relevance 0.04
The mRNA expressions of p38-regulated, profibrotic connective tissue growth factor (CTGF) and proinflammatory interleukin -6 (IL-6) tended to be increased in post-MI GK rats (Figure 7C-D).


Positive_regulation (increased) of GK in connective tissue associated with myocardial infarction
10) Confidence 0.13 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.32 Pain Relevance 0
MI tended to increase ANP mRNA expression in Wistar and GK rats (Figure 2D).


Positive_regulation (increase) of GK associated with myocardial infarction
11) Confidence 0.13 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 2.15 Pain Relevance 0.05
Immunohistochemistry was performed to examine whether the pattern of distribution of OX1R is similar in the pancreatic islets of GK compared to Wistar rats.
Spec (whether) Positive_regulation (pancreatic islets) of GK in pancreatic islets
12) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799220 Disease Relevance 1.11 Pain Relevance 0
However, the activity of acyl-CoA:glycerol-3- phosphate acyltransferase was stimulated by lidocaine whereas the activity of cytidine diphosphocholine:1,2-diacylglycerol cholinephosphotransferase was inhibited by lidocaine.
Positive_regulation (stimulated) of glycerol-3 associated with lidocaine
13) Confidence 0.02 Published 1994 Journal Lipids Section Abstract Doc Link 8090059 Disease Relevance 0 Pain Relevance 0.80
Deletion of the DAX 1 gene can also be part of a larger contiguous deletion including the centromeric dystrophin and glycerol kinase (GK) genes.
Positive_regulation (centromeric) of glycerol kinase
14) Confidence 0.02 Published 2008 Journal Journal of Medical Genetics Section Abstract Doc Link PMC2602739 Disease Relevance 0.16 Pain Relevance 0

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