INT56389

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Context Info
Confidence 0.54
First Reported 1994
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.69
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (S100a1) nucleus (S100a1) cytoplasm (S100a1)
Anatomy Link Frequency
brain 3
S100a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 1 100.00 Very High Very High Very High
withdrawal 5 97.28 Very High Very High Very High
Morphine 5 96.36 Very High Very High Very High
Abstinence syndrome 1 75.20 Quite High
Opioid 4 75.00 Quite High
Central nervous system 2 75.00 Quite High
agonist 2 75.00 Quite High
Hippocampus 1 75.00 Quite High
opiate 2 61.20 Quite High
MU agonist 2 60.64 Quite High
Disease Link Frequency Relevance Heat
Opiate Addiction 2 97.28 Very High Very High Very High
Convulsion 4 94.48 High High
Targeted Disruption 1 84.84 Quite High
Syndrome 1 74.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prolonged exposure to naltrexone did not modify G protein alpha subunit mRNA expression, whereas DADLE and U-50,488H, respectively, increased the levels of alpha s and alpha o mRNA in specific brain regions.
Gene_expression (expression) of protein alpha subunit mRNA in brain
1) Confidence 0.54 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8090073 Disease Relevance 0 Pain Relevance 0.23
The in situ hybridization technique was used to investigate the effect on G protein alpha subunit expression throughout the brain of rats chronically infused with naltrexone (70 micrograms/microliters, 1 microliter/h), DAGO (0.5 micrograms/microliter, 1 microliter/h), DADLE (11.4 micrograms/microliters, 1 microliter/h), DPDPE (3.4 micrograms/microliters, 1 microliter/h) and U-50,488H (4 micrograms/microliters, 1 microliter/h).
Gene_expression (expression) of protein alpha subunit in brain
2) Confidence 0.54 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8090073 Disease Relevance 0 Pain Relevance 0.11
We followed the changes in G protein alpha subunit expression and levels throughout the brain during the naltrexone-precipitated withdrawal syndrome in morphine-dependent rats.
Gene_expression (expression) of protein alpha subunit in brain associated with withdrawal and morphine
3) Confidence 0.41 Published 1995 Journal Eur. J. Neurosci. Section Abstract Doc Link 8563982 Disease Relevance 0.25 Pain Relevance 0.58
The subsequent induction of PENK and PDYN mRNAs was reduced by more than 60% by the c-fos antisense oligonucleotide, while constitutive expression of three other genes (alpha-tubulin, NMDA receptor-1, and GS protein alpha-subunit) was not affected.
Gene_expression (expression) of GS protein alpha-subunit associated with nmda receptor
4) Confidence 0.16 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9555037 Disease Relevance 0.44 Pain Relevance 0.09

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