INT56433

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Context Info
Confidence 0.13
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.87
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
oocytes 1
Cl (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 3 91.36 High High
antagonist 1 80.12 Quite High
Inflammatory mediators 1 75.00 Quite High
Glutamate 7 70.88 Quite High
Sicca syndrome 3 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
medulla 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 153 99.00 Very High Very High Very High
Pressure And Volume Under Development 9 95.68 Very High Very High Very High
Kidney Stones 123 91.44 High High
Familial Hypophosphatemia 6 90.68 High High
Sprains And Strains 9 90.48 High High
Proteinuria 48 89.92 High High
Congenital Anomalies 9 89.92 High High
Targeted Disruption 17 89.12 High High
INFLAMMATION 1 75.00 Quite High
Dent Disease 57 61.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Accordingly, the loss of the endosomal Cl- conductance mediated by ClC-5 would impair vesicular acidification, causing dysfunction of PT cells.
Negative_regulation (loss) of Cl
1) Confidence 0.13 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2964617 Disease Relevance 0.46 Pain Relevance 0
Indeed heterologous expression of these Dent's disease CLCN5 mutants, in either Xenopus laevis oocytes or HEK293 cells, has revealed that the majority of CLCN5 mutations lead to a loss of Cl- conductance [5].
Negative_regulation (loss) of Cl in oocytes associated with disease
2) Confidence 0.12 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2964617 Disease Relevance 0.31 Pain Relevance 0
These findings suggest a role for a reduced endosomal Cl- accumulation in Dent's disease and, by extension, point to the importance of Cl- concentration for organelle physiology [26].
Negative_regulation (reduced) of Cl associated with disease
3) Confidence 0.12 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2964617 Disease Relevance 0.79 Pain Relevance 0.04
We showed that five different dBest1 RNAi constructs abolished endogenous Cl?
Negative_regulation (abolished) of Cl
4) Confidence 0.07 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2571971 Disease Relevance 0.24 Pain Relevance 0
In addition, histamine increased the serosal-to-mucosal Na and Cl fluxes and inhibited the mucosal-to-serosal Na flux, resulting in a reduction of net Na and Cl absorption.
Negative_regulation (reduction) of Cl
5) Confidence 0.03 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8093732 Disease Relevance 0.07 Pain Relevance 0.32

General Comments

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