INT56445

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Context Info
Confidence 0.39
First Reported 1993
Last Reported 2010
Negated 7
Speculated 1
Reported most in Body
Documents 14
Total Number 19
Disease Relevance 15.40
Pain Relevance 5.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Icam1) cell adhesion (Icam1) plasma membrane (Icam1)
Anatomy Link Frequency
peripheral nerve 1
heart 1
T cells 1
neutrophil 1
Icam1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 41 100.00 Very High Very High Very High
Paracetamol 11 100.00 Very High Very High Very High
Inflammatory mediators 8 100.00 Very High Very High Very High
allodynia 8 99.60 Very High Very High Very High
Inflammation 193 99.50 Very High Very High Very High
cytokine 61 99.44 Very High Very High Very High
Angina 68 98.20 Very High Very High Very High
rheumatoid arthritis 34 97.36 Very High Very High Very High
metalloproteinase 74 97.20 Very High Very High Very High
Neurotransmitter 2 91.28 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 201 100.00 Very High Very High Very High
Adhesions 101 100.00 Very High Very High Very High
Neuropathic Pain 12 99.60 Very High Very High Very High
Coronary Heart Disease 182 99.36 Very High Very High Very High
Myocardial Infarction 96 98.62 Very High Very High Very High
Cv General 3 Under Development 69 98.20 Very High Very High Very High
Rheumatoid Arthritis 35 97.36 Very High Very High Very High
Injury 25 96.88 Very High Very High Very High
Disease 59 95.60 Very High Very High Very High
Targeted Disruption 6 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We therefore determined in mice the effects of hepatotoxic doses of AAP on the messenger RNA for intercellular adhesion molecule-1 (ICAM-1), which is a critical determinant of neutrophil adhesion, activation and ultimately of neutrophil-mediated tissue injury.
Spec (determined) Regulation (effects) of ICAM-1 in neutrophil associated with paracetamol, injury and adhesions
1) Confidence 0.39 Published 1993 Journal Biochem. Pharmacol. Section Abstract Doc Link 8094617 Disease Relevance 0.74 Pain Relevance 0.50
ICAM-1 values are located in the opposite direction, indicating a negative correlation with OXANO levels as well as MMP values.
Regulation (values) of ICAM-1 associated with metalloproteinase
2) Confidence 0.25 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1868659 Disease Relevance 0.23 Pain Relevance 0.20
The lack of a positive correlation between radicals and these markers of inflammation, as well as between clinical parameters known to be associated with increased radical production, indicates that the possible hypoperfusion that occurs during carotid endarterectomy, and which is responsible for radical production, is not enhanced enough to cause cerebral inflammation, resulting in increased ICAM-1 and MCP-1 values.
Regulation (values) of ICAM-1 associated with inflammation
3) Confidence 0.25 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1868659 Disease Relevance 0.79 Pain Relevance 0.33
In contrast, persistent mechanical allodynia and enhanced spinal PECAM, ICAM, MHC class II and CD4 immunoreactivity was observed following peripheral nerve transection.
Regulation (immunoreactivity) of ICAM in peripheral nerve associated with allodynia
4) Confidence 0.25 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 11960644 Disease Relevance 1.04 Pain Relevance 0.63
There were no significant differences in sICAM-1 levels among patients with different genotypes (P=.532).
Neg (no) Regulation (differences) of sICAM-1
5) Confidence 0.24 Published 2010 Journal Annals of Saudi Medicine Section Abstract Doc Link PMC2994157 Disease Relevance 1.31 Pain Relevance 0.33
Serum sICAM-1 is not influenced by this polymorphism and is not necessarily elevated in CHD.



Neg (not) Regulation (influenced) of sICAM-1 associated with coronary heart disease
6) Confidence 0.24 Published 2010 Journal Annals of Saudi Medicine Section Abstract Doc Link PMC2994157 Disease Relevance 1.12 Pain Relevance 0.28
There were no significant differences in sICAM-1 levels between patients with different genotypes; EE (mean [SD], 809.51 (132.8)pg/mL), EK (mean [SD], 816.21 (116.82)pg/mL) and KK (mean [SD], 847.23 (125.7)pg/mL) (P=.532).
Neg (no) Regulation (differences) of sICAM-1
7) Confidence 0.24 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2994157 Disease Relevance 1.10 Pain Relevance 0.17
Circulating sICAM-1 is not influenced by this polymorphism and is not necessarily elevated in acute coronary heart disease.



Neg (not) Regulation (influenced) of sICAM-1 in heart associated with coronary heart disease
8) Confidence 0.24 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2994157 Disease Relevance 1.10 Pain Relevance 0.18
Previous studies compared ICAM-1 K469E polymorphisms between MI and CHD group as a whole.714 In our work, there were no significant differences in sICAM-1 levels between CHD patients and control subjects (P=.37) and no significant differences in sICAM-1 levels among patients with different genotypes (P=.53).
Neg (no) Regulation (differences) of sICAM-1 associated with coronary heart disease and myocardial infarction
9) Confidence 0.24 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2994157 Disease Relevance 1.15 Pain Relevance 0.09
Intraplantar zymosan produced transient allodynia and only PECAM and ICAM immunoreactivity.
Regulation (immunoreactivity) of ICAM associated with allodynia
10) Confidence 0.21 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 11960644 Disease Relevance 1.05 Pain Relevance 0.62
Effect of GW0742- treatment on ICAM and P-selectin expression
Regulation (treatment) of ICAM
11) Confidence 0.18 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0.28 Pain Relevance 0.14
Quantitative polymerase chain reaction Mac-1 analysis shows that LPS-induced transcription of E-selectin mRNA was dramatically suppressed by both 25 and 50 mg/kg of tepoxalin, whereas the level of ICAM-1 was only affected by 50 mg/kg of tepoxalin.
Regulation (affected) of ICAM-1
12) Confidence 0.16 Published 1996 Journal Eur. J. Immunol. Section Abstract Doc Link 8566054 Disease Relevance 0.58 Pain Relevance 0.35
CD54, was up regulated on CD11c+ T cells, while expression on CD11c- T cells was comparable to pulmonary CD8+ T cells from naïve mice (Figure 2b).
Regulation (regulated) of CD54 in T cells
13) Confidence 0.16 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.29 Pain Relevance 0
There was no treatment effect on the other biomarkers (ICAM, VCAM, E-selectin, trasforming growth factor-?
Neg (no) Regulation (effect) of ICAM
14) Confidence 0.11 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464748 Disease Relevance 0.96 Pain Relevance 0.23
A placebo-controlled pilot study targeting the intercellular adhesion molecule ICAM-1, using an antisense oligodeoxynucleotide in patients with active RA, showed a modest improvement in clinical disease in the treatment group in comparison with the placebo group. [55].
Regulation (targeting) of ICAM-1 associated with rheumatoid arthritis, disease and adhesions
15) Confidence 0.05 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128900 Disease Relevance 1.26 Pain Relevance 0.50
As shown in Fig. 5, CME similarly to LPS, induced dramatic up-regulation of ICAM-1 and B7-1/-2 molecules.


Regulation (regulation) of ICAM-1
16) Confidence 0.04 Published 2010 Journal Immune Network Section Body Doc Link PMC2881426 Disease Relevance 0 Pain Relevance 0.27
in

the suppressive effect of telmisartan on the inflammatory mediators, ICAM-1,

Regulation (effect) of ICAM-1 associated with inflammatory mediators
17) Confidence 0.04 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396446 Disease Relevance 0.82 Pain Relevance 0.16
Marked alterations in expressio n of immunomodulator mRNA, including C-C chemokine RANTES, C-C chemokine receptors CCR1, CCR3 and CCR5, adhesion molecules PECAM-1, ICAM-1, and VCAM-1, cytokines IF N-gamma, TNF-alpha, IL-12, IL-4, and iNOS were observed to be up-regulated, while growth factors, GDF-2 and TGF-beta precursor, were down-regulated (Table 2, P < 0.05) at peak parasitaemia.


Regulation (alterations) of ICAM-1 associated with chemokine, adhesions and cytokine
18) Confidence 0.03 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.13 Pain Relevance 0.23
Another study of DHT (dihydrotestosterone) treatment in 33 men with partial androgen deficiency also reported no changes in either CRP, sICAM-1 or sVCAM-1 serum levels [42].
Neg (no) Regulation (changes) of sICAM-1
19) Confidence 0.01 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2693125 Disease Relevance 0.46 Pain Relevance 0.09

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