INT56446

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Context Info
Confidence 0.40
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 8.84
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Icam1) cell adhesion (Icam1) plasma membrane (Icam1)
Anatomy Link Frequency
neutrophils 2
macrophage 1
monocyte 1
Icam1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 21 100.00 Very High Very High Very High
cva 4 100.00 Very High Very High Very High
Paracetamol 11 96.04 Very High Very High Very High
Inflammation 91 93.04 High High
rheumatoid arthritis 1 89.60 High High
Inflammatory response 30 85.36 High High
fibrosis 1 83.08 Quite High
cINOD 4 63.44 Quite High
Substantia nigra 37 60.24 Quite High
Restless leg syndrome 1 56.72 Quite High
Disease Link Frequency Relevance Heat
Disease 44 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 5 100.00 Very High Very High Very High
Cv General 3 Under Development 4 100.00 Very High Very High Very High
Reprotox - General 1 3 100.00 Very High Very High Very High
Malignant Neoplastic Disease 2 100.00 Very High Very High Very High
Injury 113 99.96 Very High Very High Very High
Endotoxemia 21 99.66 Very High Very High Very High
Hypertension 2 98.12 Very High Very High Very High
Necrosis 22 94.76 High High
Burns 72 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, doses of bacterial lipopolysaccharide (LPS) did cause a rapid and dramatic increase in ICAM-1 message, which was accompanied by a much greater hepatic accumulation of neutrophils, but which led to only scattered single cell necrosis.
Positive_regulation (cause) of Positive_regulation (increase) of ICAM-1 in neutrophils associated with necrosis
1) Confidence 0.40 Published 1993 Journal Biochem. Pharmacol. Section Abstract Doc Link 8094617 Disease Relevance 0.85 Pain Relevance 0.60
In vivo administration of CORM-2 was able to inhibit the upregulation of ICAM-1 induced by thermal injury.
Positive_regulation (induced) of Positive_regulation (upregulation) of ICAM-1 associated with injury
2) Confidence 0.35 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2430988 Disease Relevance 1.71 Pain Relevance 0.24
In vivo administration of CORM-2 was able to inhibit the upregulation of ICAM-1 induced by thermal injury.
Positive_regulation (upregulation) of Positive_regulation (induced) of ICAM-1 associated with injury
3) Confidence 0.35 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2430988 Disease Relevance 1.71 Pain Relevance 0.24
The transcriptional activation of p65 and p50, the accumulation of p65 protein, and the induction of ICAM-1 were all attenuated in the Fc?
Positive_regulation (attenuated) of Positive_regulation (induction) of ICAM-1
4) Confidence 0.24 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0.05 Pain Relevance 0.03
After trauma, inducible ICAM-1 is quickly upregulated, especially in the core of the insult [62].
Positive_regulation (upregulated) of Positive_regulation (inducible) of ICAM-1 associated with injury
5) Confidence 0.13 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2988764 Disease Relevance 1.06 Pain Relevance 0.04
In parallel, endotoxemia in 37°C animals induced a marked increase of sP-selectin, sE-selectin, sICAM-1 and sVCAM-1 when compared to 37°C saline controls (Figure 3).
Positive_regulation (induced) of Positive_regulation (increase) of sICAM-1 associated with endotoxemia
6) Confidence 0.13 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.78 Pain Relevance 0
The higher levels of MIF associated with this particular variant also correlated with progressive disease.16 In relation to malignant diseases, individuals carrying the seven-repeat allele were also found to have an increased incidence of prostate cancer.17 MIF biological activity has also been implicated in the pathogenesis of atherosclerosis and abdominal aortic aneurysm.18 In the context of atherosclerosis, MIF has also been identified as a non-cognate receptor of CXCR2 and CXCR4 and has functional chemokine activity in evolving atherosclerosis mediating monocyte arrest and the formation of plaques.19 Additionally, as part of this disease process MIF can induce the CXCR ligand, Interleukin (IL)-8 and regulators of macrophage infiltration ICAM-1 and CD44, confirming its relevance in this disease.20
Positive_regulation (relation) of in monocyte Positive_regulation (infiltration) of ICAM-1 in macrophage associated with chemokine, malignant neoplastic disease, cva, increased venous pressure under development, disease and reprotox - general 1
7) Confidence 0.09 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 2.67 Pain Relevance 0.49

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