INT56447

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Context Info
Confidence 0.64
First Reported 1993
Last Reported 2010
Negated 4
Speculated 2
Reported most in Body
Documents 64
Total Number 66
Disease Relevance 64.14
Pain Relevance 16.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Icam1) cell adhesion (Icam1) plasma membrane (Icam1)
Anatomy Link Frequency
T cell 4
leukocytes 3
plasma 2
macrophages 2
monocyte 2
Icam1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 884 100.00 Very High Very High Very High
Central nervous system 224 100.00 Very High Very High Very High
allodynia 6 99.90 Very High Very High Very High
Sciatic nerve 39 99.84 Very High Very High Very High
Paracetamol 35 99.82 Very High Very High Very High
Angina 121 99.28 Very High Very High Very High
chemokine 142 99.02 Very High Very High Very High
Inflammatory response 100 97.68 Very High Very High Very High
dexamethasone 6 97.32 Very High Very High Very High
anesthesia 46 97.18 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1027 100.00 Very High Very High Very High
Adhesions 496 100.00 Very High Very High Very High
Cancer 134 100.00 Very High Very High Very High
Cardiovascular Disease 90 100.00 Very High Very High Very High
Necrosis 87 100.00 Very High Very High Very High
Alzheimer's Dementia 4 100.00 Very High Very High Very High
Enteropathy 1 100.00 Very High Very High Very High
Injury 267 99.96 Very High Very High Very High
Neuropathic Pain 8 99.90 Very High Very High Very High
Coronary Heart Disease 318 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of these, increased expression of P-selectin, ICAM-1 and CCL12 after carrageenan injection could be verified by real-time RT-PCR on both the right and left sides, and increased in P-selectin and ICAM-1 further verified by Western blot analysis.
Positive_regulation (increased) of ICAM-1
1) Confidence 0.64 Published 2009 Journal Pain Section Abstract Doc Link 19167818 Disease Relevance 0.56 Pain Relevance 0.51
Stimulation with interleukin-1 beta for a further 16 h increased the levels of intercellular adhesion molecule-1, and this effect was inhibited by co-incubation with 0.1-1 microM dexamethasone.
Positive_regulation (increased) of intercellular adhesion molecule-1 associated with dexamethasone and adhesions
2) Confidence 0.63 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8660354 Disease Relevance 0.33 Pain Relevance 0.15
However, sICAM-1 level elevation among patients with coronary disease was reported by Ridker et al,16 Malik et al17 and Güray et al.18 Also, in the Han population of China, individuals with the K allele had higher plasma level of sICAM-1 than those without the K allele.10 This difference in results may be due to the fact that most of the patients in the current study had an acute condition, while the patients in some of the previous studies had chronic CHD.
Positive_regulation (elevation) of sICAM-1 in plasma associated with coronary heart disease
3) Confidence 0.61 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2994157 Disease Relevance 1.12 Pain Relevance 0.09
However, doses of bacterial lipopolysaccharide (LPS) did cause a rapid and dramatic increase in ICAM-1 message, which was accompanied by a much greater hepatic accumulation of neutrophils, but which led to only scattered single cell necrosis.
Positive_regulation (increase) of ICAM-1 in neutrophils associated with necrosis
4) Confidence 0.60 Published 1993 Journal Biochem. Pharmacol. Section Abstract Doc Link 8094617 Disease Relevance 0.85 Pain Relevance 0.59
We conclude from these studies that upregulation of ICAM-1 and subsequent adhesion and vascular plugging by neutrophils are not significant determinants of AAP-induced liver swelling and necrosis and that whatever hemorheological advantages PTX might offer in AAP-induced hepatic damage appear to be overshadowed by effects that potentiate the toxic responses.
Positive_regulation (upregulation) of ICAM-1 in liver associated with necrosis, pressure and volume under development, paracetamol and adhesions
5) Confidence 0.60 Published 1993 Journal Biochem. Pharmacol. Section Abstract Doc Link 8094617 Disease Relevance 1.04 Pain Relevance 0.74
In order to get insight into the mechanism of cadmium (Cd)-induced brain injury, we investigated the effects of Cd on the induction of COX-2 and ICAM-1 in bEnd.3 mouse brain endothelial cells (EC).
Spec (investigated) Positive_regulation (induction) of ICAM-1 in brain associated with brain injury
6) Confidence 0.60 Published 2006 Journal Toxicol. Lett. Section Abstract Doc Link 16777358 Disease Relevance 0.22 Pain Relevance 0.06
Serum levels of soluble P-selectin, ICAM-1 and VCAM-1 are elevated in patients with angina pectoris or peripheral atherosclerotic disease.
Positive_regulation (elevated) of ICAM-1 associated with angina, atherosclerosis and disease
7) Confidence 0.59 Published 2001 Journal Acta Physiol. Scand. Section Abstract Doc Link 11678724 Disease Relevance 1.25 Pain Relevance 0.18
Mice subjected to renal IR under isoflurane anesthesia also showed a reduction in inflammation evidenced by a reduced renal influx of neutrophils and macrophages, reduced ICAM-1 expression, less upregulation of proinflammatory mRNAs (TNF-alpha, ICAM-1, KC, and IL-1beta) as well as reduced nuclear translocation of NF-kappaB 24 h after renal IR injury.
Positive_regulation (upregulation) of ICAM-1 in neutrophils associated with anesthesia, inflammation, injury and isoflurane
8) Confidence 0.55 Published 2007 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 17596528 Disease Relevance 1.32 Pain Relevance 1.06
We found prominent induction of ICAM-1 and to a lesser degree of VCAM-1 (Figs. 4, 5, 6), but not of mucosal addressin cell adhesion molecule (MAdCAM)-1, E-selectin or P-selectin (Table 1) on CVO microvessels during EAE.
Positive_regulation (induction) of ICAM-1 associated with multiple sclerosis and adhesions
9) Confidence 0.55 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.88 Pain Relevance 0.04
First, overexpression of IL-10 results in upregulation of ICAM-1 on sciatic nerve tissue.
Positive_regulation (upregulation) of ICAM-1 in sciatic nerve associated with sciatic nerve
10) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743195 Disease Relevance 1.11 Pain Relevance 0.28
The present results showed that at 24h post-burn, the expression levels of ICAM-1 in renal tissue were markedly upregulated.
Positive_regulation (upregulated) of ICAM-1 associated with burns
11) Confidence 0.51 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2430988 Disease Relevance 1.62 Pain Relevance 0.22
In vivo administration of CORM-2 was able to inhibit the upregulation of ICAM-1 induced by thermal injury.
Positive_regulation (upregulation) of ICAM-1 associated with injury
12) Confidence 0.51 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2430988 Disease Relevance 1.71 Pain Relevance 0.24
The plasma concentration of ICAM-1 as well as other adhesion molecules is increased in conjunction with transient ischaemic attacks, indicating a central nervous system inflammatory reaction 16.
Positive_regulation (increased) of ICAM-1 in central nervous system associated with brain hemorrhage, inflammation, central nervous system and adhesions
13) Confidence 0.47 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1868659 Disease Relevance 1.21 Pain Relevance 0.58
Elevations in markers of inflammation and thrombosis, such as high sensitivity C-reactive protein, soluble intercellular adhesion molecule, homocysteine and fibrinogen, are also associated with increased CVD risk.1 Intercellular adhesion molecule-1 (ICAM-1) is an important inflammatory protein; it is one of the adhesion molecules that plays a key role in the recruitment of leukocytes at sites of inflammation and the tight adhesion between leukocytes and vascular endothelium.
Positive_regulation (increased) of ICAM-1 in vascular endothelium associated with inflammation, cardiovascular disease, adhesions and thrombosis
14) Confidence 0.47 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2994157 Disease Relevance 1.84 Pain Relevance 0.19
Elevations in markers of inflammation and thrombosis, such as high sensitivity C-reactive protein, soluble intercellular adhesion molecule, homocysteine and fibrinogen, are also associated with increased CVD risk.1 Intercellular adhesion molecule-1 (ICAM-1) is an important inflammatory protein; it is one of the adhesion molecules that plays a key role in the recruitment of leukocytes at sites of inflammation and the tight adhesion between leukocytes and vascular endothelium.
Positive_regulation (increased) of Intercellular adhesion molecule-1 in vascular endothelium associated with inflammation, cardiovascular disease, adhesions and thrombosis
15) Confidence 0.47 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2994157 Disease Relevance 1.84 Pain Relevance 0.19
However, sICAM-1 level elevation among patients with coronary disease was reported by Ridker et al,16 Malik et al17 and Güray et al.18 Also, in the Han population of China, individuals with the K allele had higher plasma level of sICAM-1 than those without the K allele.10 This difference in results may be due to the fact that most of the patients in the current study had an acute condition, while the patients in some of the previous studies had chronic CHD.
Positive_regulation (level) of sICAM-1 in plasma associated with coronary heart disease
16) Confidence 0.44 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2994157 Disease Relevance 1.21 Pain Relevance 0.14
Hepatotoxic doses of AAP did not upregulate ICAM-1 messenger RNA.
Neg (not) Positive_regulation (upregulate) of ICAM-1 messenger RNA associated with paracetamol
17) Confidence 0.44 Published 1993 Journal Biochem. Pharmacol. Section Abstract Doc Link 8094617 Disease Relevance 0.74 Pain Relevance 0.49
In a high cholesterol/cholate model, a role of ICAM-1 and CD18 integrins was also shown, but this awaits confirmation in more physiologic models.
Positive_regulation (role) of ICAM-1
18) Confidence 0.42 Published 2001 Journal Acta Physiol. Scand. Section Abstract Doc Link 11678724 Disease Relevance 1.10 Pain Relevance 0.10
Circulating sICAM-1 is not influenced by this polymorphism and is not necessarily elevated in acute coronary heart disease.



Neg (not) Positive_regulation (elevated) of sICAM-1 in heart associated with coronary heart disease
19) Confidence 0.41 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2994157 Disease Relevance 1.10 Pain Relevance 0.18
Serum sICAM-1 is not influenced by this polymorphism and is not necessarily elevated in CHD.



Neg (not) Positive_regulation (elevated) of sICAM-1 associated with coronary heart disease
20) Confidence 0.41 Published 2010 Journal Annals of Saudi Medicine Section Abstract Doc Link PMC2994157 Disease Relevance 1.12 Pain Relevance 0.28

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