INT56448

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 1993
Last Reported 2010
Negated 9
Speculated 10
Reported most in Body
Documents 52
Total Number 62
Disease Relevance 55.10
Pain Relevance 10.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ICAM1) cell adhesion (ICAM1) plasma membrane (ICAM1)
Anatomy Link Frequency
plasma 4
neutrophil 3
synovial fluid 2
leukocyte 2
endothelium 2
ICAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1058 100.00 Very High Very High Very High
cytokine 153 100.00 Very High Very High Very High
Paracetamol 11 100.00 Very High Very High Very High
diclofenac 53 99.56 Very High Very High Very High
ischemia 35 98.24 Very High Very High Very High
aspirin 29 97.48 Very High Very High Very High
cva 54 97.32 Very High Very High Very High
Angina 53 97.32 Very High Very High Very High
interstitial cystitis 2 96.44 Very High Very High Very High
dexamethasone 106 96.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nicotine Addiction 2943 100.00 Very High Very High Very High
Adhesions 1762 100.00 Very High Very High Very High
INFLAMMATION 1249 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 320 100.00 Very High Very High Very High
Polymyalgia Rheumatica 76 99.76 Very High Very High Very High
Focal Cartilage Defect 56 99.64 Very High Very High Very High
Giant Cell Arteritis 78 99.44 Very High Very High Very High
Diabetes Mellitus 289 99.04 Very High Very High Very High
Disease 620 98.68 Very High Very High Very High
Pulmonary Disease 83 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transcriptional regulation of ICAM-1 is particularly complex, with unusual post-transcriptional control mechanisms described [50,51,66].
Regulation (regulation) of ICAM-1
1) Confidence 0.60 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 0.43 Pain Relevance 0.03
Transcriptional regulation of ICAM-1 is particularly complex, with unusual post-transcriptional control mechanisms described [50,51,66].
Regulation (regulation) of ICAM-1
2) Confidence 0.60 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 0.43 Pain Relevance 0.03
Therefore, sICAM-1 levels where not influenced by the acute event.
Neg (not) Regulation (influenced) of sICAM-1
3) Confidence 0.52 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.44 Pain Relevance 0.17
Therefore, sICAM-1 levels where not influenced by the acute event.
Regulation (influenced) of sICAM-1
4) Confidence 0.52 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.44 Pain Relevance 0.17
The two control groups, tested with the same experimental procedure, showed no changes in ICAM-1 and IL-1R or in in sICAM-1 and IL-4.
Neg (no) Regulation (changes) of ICAM-1
5) Confidence 0.47 Published 1997 Journal J. Mol. Med. Section Abstract Doc Link 9231885 Disease Relevance 1.11 Pain Relevance 0.91
The reduced angiogenic response and compromised endothelial ICAM-1 expression profiles in the gingival tissues of smokers may help explain this initially surprising observation.
Regulation (response) of ICAM-1 associated with nicotine addiction
6) Confidence 0.44 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.62 Pain Relevance 0.06
The reduced angiogenic response and compromised endothelial ICAM-1 expression profiles in the gingival tissues of smokers may help explain this initially surprising observation.
Regulation (response) of ICAM-1 associated with nicotine addiction
7) Confidence 0.44 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.62 Pain Relevance 0.06
Changes of membrane-bound ICAM-1 and soluble ICAM-1 were maximal with high concentrations of trypsin.
Regulation (Changes) of ICAM-1
8) Confidence 0.44 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15308472 Disease Relevance 0.23 Pain Relevance 0
Changes of membrane-bound ICAM-1 and soluble ICAM-1 were maximal with high concentrations of trypsin.
Regulation (Changes) of ICAM-1
9) Confidence 0.44 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15308472 Disease Relevance 0.23 Pain Relevance 0
In this research, human synovial MSCs attached to the cartilage defect 10 minutes after plating already expressed ICAM-1 and VCAM-1, and neutralizing antibodies for ICAM-1, VCAM-1, or activated leukocyte-cell adhesion molecule inhibited the attachment.
Regulation (antibodies) of ICAM-1 in leukocyte associated with focal cartilage defect and adhesions
10) Confidence 0.40 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575632 Disease Relevance 0.55 Pain Relevance 0
In this research, human synovial MSCs attached to the cartilage defect 10 minutes after plating already expressed ICAM-1 and VCAM-1, and neutralizing antibodies for ICAM-1, VCAM-1, or activated leukocyte-cell adhesion molecule inhibited the attachment.
Regulation (plating) of ICAM-1 in leukocyte associated with focal cartilage defect and adhesions
11) Confidence 0.40 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575632 Disease Relevance 0.59 Pain Relevance 0
Effect of diagnostic hydrodistension and four intravesical hyaluronic acid instillations on bladder ICAM-1 intensity and association of ICAM-1 intensity with clinical response in patients with interstitial cystitis.
Regulation (Effect) of ICAM in bladder associated with interstitial cystitis
12) Confidence 0.39 Published 2002 Journal Urology Section Title Doc Link 12100920 Disease Relevance 0.28 Pain Relevance 0.19
One therapeutic strategy could involve the targeting of intercellular adhesion molecule-1 (ICAM-1; CD54).
Regulation (targeting) of ICAM-1 associated with adhesions
13) Confidence 0.39 Published 2005 Journal Expert Opin Biol Ther Section Abstract Doc Link 15833069 Disease Relevance 1.15 Pain Relevance 0.31
Involvement of ICAM-1 in bone metabolism: a potential target in the treatment of bone diseases?
Regulation (Involvement) of ICAM-1 associated with bone cancer
14) Confidence 0.39 Published 2005 Journal Expert Opin Biol Ther Section Title Doc Link 15833069 Disease Relevance 1.17 Pain Relevance 0.32
One therapeutic strategy could involve the targeting of intercellular adhesion molecule-1 (ICAM-1; CD54).
Regulation (targeting) of intercellular adhesion molecule-1 associated with adhesions
15) Confidence 0.39 Published 2005 Journal Expert Opin Biol Ther Section Abstract Doc Link 15833069 Disease Relevance 1.15 Pain Relevance 0.31
Recently, Becker et al. [149] have suggested that the significant relationship between elevated systemic sICAM-1 and vascular disease is independent of renal function and major risk factors such as clinical or sub-clinical atherosclerosis (prior vascular disease or ankle-brachial pressure index), endothelial activation (von Willebrand factor), inflammation (C-reactive protein), or elevated sVCAM-1.
Regulation (independent) of sICAM-1 in ankle associated with inflammation and increased venous pressure under development
16) Confidence 0.38 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.41 Pain Relevance 0.08
Recently, Becker et al. [149] have suggested that the significant relationship between elevated systemic sICAM-1 and vascular disease is independent of renal function and major risk factors such as clinical or sub-clinical atherosclerosis (prior vascular disease or ankle-brachial pressure index), endothelial activation (von Willebrand factor), inflammation (C-reactive protein), or elevated sVCAM-1.
Neg (independent) Regulation (independent) of sICAM-1 in ankle associated with inflammation and increased venous pressure under development
17) Confidence 0.38 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.41 Pain Relevance 0.08
The intercellular adhesion molecule (ICAM-1) is a member of the immunoglobulin-like superfamily group of adhesion molecules and is a ligand for ?
Regulation (intercellular) of ICAM-1 associated with adhesions
18) Confidence 0.36 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128892 Disease Relevance 1.65 Pain Relevance 0.16
Our analysis identified key regulators of innate immunity and inflammation including the proinflammatory mediators formyl peptide receptor 1, ICAM-1 (intercellular adhesion molecule-1), thymosin ?
Regulation (regulators) of ICAM-1 associated with inflammation and adhesions
19) Confidence 0.36 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400410 Disease Relevance 0.54 Pain Relevance 0.09
Our analysis identified key regulators of innate immunity and inflammation including the proinflammatory mediators formyl peptide receptor 1, ICAM-1 (intercellular adhesion molecule-1), thymosin ?
Regulation (thymosin) of ICAM-1 associated with inflammation and adhesions
20) Confidence 0.36 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400410 Disease Relevance 0.53 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox