INT56450

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Context Info
Confidence 0.52
First Reported 1993
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 33
Total Number 34
Disease Relevance 27.21
Pain Relevance 10.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Icam1) cell adhesion (Icam1) plasma membrane (Icam1)
Anatomy Link Frequency
leukocytes 10
neutrophil 8
plasma 4
monocyte 4
endothelium 3
Icam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 355 100.00 Very High Very High Very High
Arthritis 99 100.00 Very High Very High Very High
aspirin 20 99.84 Very High Very High Very High
Infliximab 96 99.70 Very High Very High Very High
Hippocampus 4 99.68 Very High Very High Very High
interstitial cystitis 9 99.66 Very High Very High Very High
MU agonist 2 99.60 Very High Very High Very High
cytokine 133 99.48 Very High Very High Very High
Etanercept 6 99.38 Very High Very High Very High
cINOD 32 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 401 100.00 Very High Very High Very High
Adhesions 186 100.00 Very High Very High Very High
Cancer 42 100.00 Very High Very High Very High
Hepatocellular Cancer 8 100.00 Very High Very High Very High
Experimental Arthritis 1 100.00 Very High Very High Very High
Interstitial Cystitis 9 99.66 Very High Very High Very High
Neurodegenerative Disease 15 99.56 Very High Very High Very High
Injury 106 99.40 Very High Very High Very High
Necrosis 58 99.40 Very High Very High Very High
Hemorrhagic Shock 26 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High-dose aspirin, etanercept, and high-dose meloxicam each reduced retinal ICAM-1 expression.
Negative_regulation (reduced) of Gene_expression (expression) of ICAM-1 associated with aspirin and etanercept
1) Confidence 0.52 Published 2002 Journal FASEB J. Section Abstract Doc Link 11821258 Disease Relevance 0.95 Pain Relevance 0.77
Involvement of reduced endothelial intercellular adhesion molecule-1 expression might explain the lower numbers of adherent and migrated leukocytes.
Negative_regulation (reduced) of Gene_expression (expression) of endothelial intercellular adhesion molecule-1 in leukocytes associated with adhesions
2) Confidence 0.44 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 14716214 Disease Relevance 0.58 Pain Relevance 0.55
Our data showed that the mRNA expression of ICAM-1 was significantly suppressed by curcumin in vitro and in vivo (Fig. 3B and C).
Negative_regulation (suppressed) of Gene_expression (expression) of ICAM
3) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945766 Disease Relevance 1.31 Pain Relevance 0.53
Intercellular adhesion molecule-1 expression in adjuvant arthritis in rats: inhibition by kappa-opioid agonist but not by NSAID.
Negative_regulation (inhibition) of Gene_expression (expression) of Intercellular adhesion molecule-1 associated with mu agonist, cinod, experimental arthritis, adhesions and arthritis
4) Confidence 0.43 Published 1998 Journal J. Rheumatol. Section Title Doc Link 9517771 Disease Relevance 0.39 Pain Relevance 0.42
This is likely accomplished by reducing the expression of endothelial adhesion molecules, ICAM-1 and VCAM-1, and by downregulating the production of chemokines [23,24].
Negative_regulation (reducing) of Gene_expression (expression) of ICAM-1 associated with chemokine and adhesions
5) Confidence 0.40 Published 2010 Journal Crit Care Section Body Doc Link PMC2945141 Disease Relevance 1.18 Pain Relevance 0.55
All the treatments tested reduced the number of rollers, adherent and migrated leukocytes, and the expression of endothelial intercellular adhesion molecule-1 and P-selectin.
Negative_regulation (reduced) of Gene_expression (expression) of endothelial intercellular adhesion molecule-1 in leukocytes associated with adhesions
6) Confidence 0.39 Published 2005 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 16044031 Disease Relevance 0.57 Pain Relevance 0.56
Losartan has an antimigratory effect, reducing leukocyte migration by reducing ICAM-1 and P-selectin expression.
Negative_regulation (reducing) of Gene_expression (expression) of ICAM-1 in leukocyte
7) Confidence 0.39 Published 2005 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 16044031 Disease Relevance 0.24 Pain Relevance 0.35
number of ICAM-1-positive vessels was significantly decreased (P < .05) (see Figures 4(c) and 4(d)).
Negative_regulation (decreased) of Gene_expression (vessels) of ICAM-1-positive in vessels
8) Confidence 0.39 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2375967 Disease Relevance 0.88 Pain Relevance 0.07
Proteasome inhibitor treatment also abolished the increase in gastric mucosal permeability and the increase in gastric endothelial ICAM expression induced by indomethacin.
Negative_regulation (abolished) of Gene_expression (expression) of ICAM
9) Confidence 0.37 Published 1999 Journal Gastroenterology Section Body Doc Link 10092308 Disease Relevance 0 Pain Relevance 0
However, expression in HCC of mRNAs for intercellular adhesion molecule-1 and vascular cell adhesion molecule-1, both of which are considered to play key roles in attachment of cancer cells to the endothelium, was significantly suppressed by ASP.
Negative_regulation (suppressed) of Gene_expression (expression) of intercellular adhesion molecule-1 in endothelium associated with cancer, hepatocellular cancer and adhesions
10) Confidence 0.35 Published 2002 Journal Jpn. J. Cancer Res. Section Abstract Doc Link 12417048 Disease Relevance 1.43 Pain Relevance 0.11
All treatments reduced adherent and migrated leukocytes and expression of endothelial intercellular adhesion molecule-1.
Negative_regulation (reduced) of Gene_expression (expression) of endothelial intercellular adhesion molecule-1 in leukocytes associated with adhesions
11) Confidence 0.32 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 14716214 Disease Relevance 0.44 Pain Relevance 0.52
Moreover, administration of CORM-2, but not iCORM-2, markedly inhibited the ICAM-1 expression as induced by I/Ri (Fig. 3A and 3B, p < 0.05).
Negative_regulation (inhibited) of Gene_expression (expression) of ICAM-1
12) Confidence 0.31 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2873601 Disease Relevance 0.48 Pain Relevance 0.10
In the acute phase of MI (a) sE-selectin and sICAM-1 levels increase during the first 8 h and subsequently decrease; (b) the increase in sE-selectin probably reflects activation of endothelial cells, correlates with other inflammatory and coagulation parameters, and is inversely related to the degree of myocardial damage; and (c) sICAM-1 plasma levels do not represent a good marker of "cell activation" because they reflect activation of different cells and may be affected by different conditions.
Neg (not) Negative_regulation (represent) of Gene_expression (levels) of sICAM-1 in plasma associated with inflammation
13) Confidence 0.31 Published 1997 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 9335404 Disease Relevance 0.68 Pain Relevance 0.18
However, reduced expression of inflammatory genes such as COX-2 and ICAM-1 in the hippocampus was observed.
Negative_regulation (reduced) of Gene_expression (expression) of ICAM-1 in hippocampus associated with inflammation and hippocampus
14) Confidence 0.28 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1933540 Disease Relevance 0.60 Pain Relevance 0.23
Next, we assessed whether this reduction in ICAM-1 expression was accompanied by a reduction in neutrophil infiltration.
Spec (whether) Negative_regulation (reduction) of Gene_expression (expression) of ICAM-1 in neutrophil
15) Confidence 0.27 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2873601 Disease Relevance 0.55 Pain Relevance 0.10
CORM-2 treatment prevents ICAM-1 expression and decreases neutrophil infiltration
Negative_regulation (prevents) of Gene_expression (expression) of ICAM-1 in neutrophil
16) Confidence 0.27 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2873601 Disease Relevance 0.45 Pain Relevance 0.16
, the expression of intercellular adhesion molecule-1 (ICAM-1), and monocyte chemoattractant protein-1 (MCP-1), and suppressed the infiltration of CD11b-positive macrophages. ?
Negative_regulation (suppressed) of Gene_expression (expression) of intercellular adhesion molecule-1 in monocyte associated with adhesions
17) Confidence 0.27 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2864892 Disease Relevance 0.95 Pain Relevance 0.03
Expression of ICAM-1 was markedly reduced by treatment with PDTC and was similar to the constitutive ICAM-1 expression in control animals at week 7 (Fig. 20a,b,c).
Negative_regulation (reduced) of Gene_expression (Expression) of ICAM-1
18) Confidence 0.26 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC65512 Disease Relevance 0.46 Pain Relevance 0.08
The data also showed that NF-kappaB activation and its associated gene expressions, such as COX-2, iNOS, VCAM-1 and ICAM-1, were all suppressed by the low dose aspirin supplementation through the inhibition of phosphorylation and degradation of IkappaBalpha via the NIK/IKK pathway.
Negative_regulation (suppressed) of Gene_expression (expressions) of ICAM-1 associated with aspirin
19) Confidence 0.25 Published 2006 Journal Mech. Ageing Dev. Section Abstract Doc Link 16310244 Disease Relevance 0.60 Pain Relevance 0.59
, the expression of intercellular adhesion molecule-1 (ICAM-1), and monocyte chemoattractant protein-1 (MCP-1), and suppressed the infiltration of CD11b-positive macrophages. ?
Negative_regulation (suppressed) of Gene_expression (expression) of ICAM-1 in monocyte associated with adhesions
20) Confidence 0.23 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2864892 Disease Relevance 0.95 Pain Relevance 0.03

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