INT56458

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Context Info
Confidence 0.02
First Reported 1993
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 0
Pain Relevance 3.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IGHG3)
Anatomy Link Frequency
liver 2
GPM6A (Homo sapiens)
IGHG3 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 4 99.60 Very High Very High Very High
Morphine 45 98.72 Very High Very High Very High
narcan 2 91.72 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, M3G and M6G formation by UGT2B7 exhibited atypical kinetics.
M6G Binding (formation) of M3G
1) Confidence 0.02 Published 2003 Journal Drug Metab. Dispos. Section Abstract Doc Link 12920162 Disease Relevance 0 Pain Relevance 0.35
M3G and M6G vary in their ability to interact with the opioid receptor effector system.
M6G Binding (interact) of M3G associated with opioid receptor
2) Confidence 0.01 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10686401 Disease Relevance 0 Pain Relevance 0.99
Thus, we have characterized the selectivity and kinetics of M3G and M6G formation by recombinant human UGTs.
M6G Binding (formation) of M3G
3) Confidence 0.01 Published 2003 Journal Drug Metab. Dispos. Section Abstract Doc Link 12920162 Disease Relevance 0 Pain Relevance 0.34
Thus, we have characterized the selectivity and kinetics of M3G and M6G formation by recombinant human UGTs.
M6G Binding (formation) of M3G
4) Confidence 0.01 Published 2003 Journal Drug Metab. Dispos. Section Abstract Doc Link 12920162 Disease Relevance 0 Pain Relevance 0.34
At high concentration (100 microM), rates of M3G and M6G formation in liver cells exceeded by 5- to 10-fold those of intestinal or colonic cells.
M6G Binding (formation) of M3G in liver
5) Confidence 0.00 Published 1993 Journal Drug Metab. Dispos. Section Abstract Doc Link 8095206 Disease Relevance 0 Pain Relevance 0.64
At high concentration (100 microM), rates of M3G and M6G formation in liver cells exceeded by 5- to 10-fold those of intestinal or colonic cells.
M6G Binding (formation) of M3G in liver
6) Confidence 0.00 Published 1993 Journal Drug Metab. Dispos. Section Abstract Doc Link 8095206 Disease Relevance 0 Pain Relevance 0.64

General Comments

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