INT5647

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Context Info
Confidence 0.30
First Reported 1992
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.60
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
caudate nucleus 1
putamen 1
ganglion 1
heart 1
Mptp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 14 99.44 Very High Very High Very High
Morphine 1 99.32 Very High Very High Very High
methadone 1 98.00 Very High Very High Very High
opiate 1 96.92 Very High Very High Very High
narcan 3 94.40 High High
antagonist 1 93.56 High High
substance P 12 91.36 High High
Nucleus accumbens 8 91.16 High High
Angina 1 90.08 High High
Analgesic 1 89.92 High High
Disease Link Frequency Relevance Heat
Parkinson's Disease 34 100.00 Very High Very High Very High
Toxicity 3 100.00 Very High Very High Very High
Ganglion Cysts 6 99.60 Very High Very High Very High
Reperfusion Injury 1 99.42 Very High Very High Very High
Congenital Anomalies 4 98.72 Very High Very High Very High
Cv General 3 Under Development 1 90.08 High High
Drug Induced Neurotoxicity 1 82.04 Quite High
Depression 1 66.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Like meperidine and morphine, the ganglion-blocking action of MPTP was reduced when the concentration of Ca2+ in the Locke solution was elevated.
Positive_regulation (elevated) of MPTP in ganglion associated with parkinson's disease, ganglion cysts and morphine
1) Confidence 0.30 Published 1992 Journal J Auton Pharmacol Section Abstract Doc Link 1313036 Disease Relevance 1.21 Pain Relevance 0.61
Similarly, the MPTP toxicity enhancers, DDC and acetaldehyde, both increase striatal MPP+ levels, as previously reported.
Positive_regulation (increase) of MPTP associated with parkinson's disease and toxicity
2) Confidence 0.18 Published 1996 Journal Neurodegeneration Section Abstract Doc Link 8819133 Disease Relevance 0.58 Pain Relevance 0.14
The reperfusion damages of heart were manifested by MPTP activation and MF release.
Positive_regulation (activation) of MPTP in heart associated with parkinson's disease and reperfusion injury
3) Confidence 0.10 Published 2009 Journal Fiziol Zh Section Abstract Doc Link 19441710 Disease Relevance 0.36 Pain Relevance 0.12
Seven days after MPTP treatment, there was a marked increase in levels of enkephalin mRNA in the caudate nucleus and putamen.
Positive_regulation (increase) of MPTP in putamen associated with parkinson's disease and enkephalin
4) Confidence 0.02 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7500841 Disease Relevance 0.72 Pain Relevance 0.57
Seven days after MPTP treatment, there was a marked increase in levels of enkephalin mRNA in the caudate nucleus and putamen.
Positive_regulation (increase) of MPTP in caudate nucleus associated with parkinson's disease and enkephalin
5) Confidence 0.01 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7500841 Disease Relevance 0.72 Pain Relevance 0.57

General Comments

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