INT56470

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Context Info
Confidence 0.05
First Reported 1993
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 6.78
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (MKI67) nucleolus (MKI67) nucleus (MKI67)
intracellular (MKI67) cell cycle (MKI67) DNA metabolic process (MKI67)
Anatomy Link Frequency
brains 1
MKI67 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 10 81.68 Quite High
Clonidine 3 81.08 Quite High
aspirin 5 73.60 Quite High
cINOD 5 71.04 Quite High
Potency 1 66.32 Quite High
antagonist 1 51.08 Quite High
cytokine 10 5.00 Very Low Very Low Very Low
cva 6 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 559 99.56 Very High Very High Very High
Stomach Cancer 120 98.96 Very High Very High Very High
Recurrence 9 97.24 Very High Very High Very High
Apoptosis 44 81.76 Quite High
Breast Cancer 69 79.56 Quite High
Malignant Neoplastic Disease 29 79.56 Quite High
INFLAMMATION 5 70.64 Quite High
Metastasis 11 66.08 Quite High
Disease 30 38.08 Quite Low
Advanced Or Metastatic Breast Cancer 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, the mean Ki-67 LI value of COX-2 positive tumors was significantly higher than that of COX-2 negative tumors.
Regulation (value) of Ki-67 associated with cancer
1) Confidence 0.05 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721998 Disease Relevance 1.22 Pain Relevance 0.09
The mean Ki-67 LI value of both COX-2 and p53 positive tumors was significantly higher than that of both negative tumors.
Regulation (value) of Ki-67 associated with cancer
2) Confidence 0.05 Published 2006 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2721998 Disease Relevance 1.05 Pain Relevance 0
Ki-67 immunoreactivity was almost found in the nuclei of cancer cells.
Regulation (immunoreactivity) of Ki-67 associated with cancer
3) Confidence 0.05 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721998 Disease Relevance 0.70 Pain Relevance 0
The mean Ki-67 LI value of COX-2 positive tumors was 52.3±14.6 and significantly higher than that of COX-2 negative tumors (p=0.012).
Regulation (value) of Ki-67 associated with cancer
4) Confidence 0.05 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721998 Disease Relevance 0.83 Pain Relevance 0.09
The mean Ki-67 LI value of p53 positive tumors was 50.7±14.7 and not significantly higher than that of p53 negative tumors (p=0.525).
Regulation (value) of Ki-67 associated with cancer
5) Confidence 0.05 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721998 Disease Relevance 0.87 Pain Relevance 0.11
Binding affinities at the low-affinity site (KiL) were consistently more than 2 orders of magnitude lower than binding affinities at the high-affinity site (KiH), and there was a good correlation between KiH and KiL values for a given drug in the human (r = 0.89) and rat (r = 0.92) brains.
Regulation (values) of KiH in brains
6) Confidence 0.02 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8095548 Disease Relevance 0 Pain Relevance 0.20
Preliminary data from the Immediate Preoperative Anastrozole Tamoxifen or Combined with Tamoxifen trial have indicated that short-term changes in Ki67 levels, after 2 and 12 weeks, may be a useful predictive marker for relapse-free survival in patients treated with neoadjuvant AI therapy [58].
Regulation (changes) of Ki67 associated with recurrence
7) Confidence 0.01 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001223 Disease Relevance 0.75 Pain Relevance 0
Baseline aromatase expression did not predict response to letrozole or tamoxifen, or changes in Ki67 induced by treatment.
Regulation (changes) of Ki67
8) Confidence 0.01 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001223 Disease Relevance 0.63 Pain Relevance 0
Fig. 3A box plot of before and after treatment Ki67 values in the estrogen-receptor-positive, human epidermal growth factor receptor (HER) 1/2+ subset.
Regulation (values) of Ki67
9) Confidence 0.01 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001223 Disease Relevance 0.74 Pain Relevance 0

General Comments

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