INT5648

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Context Info
Confidence 0.37
First Reported 1990
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 6.64
Pain Relevance 3.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuronal 1
neurons 1
MPTP 1
ganglion 1
mesencephalon 1
Mptp1 (Mus musculus)
Pain Link Frequency Relevance Heat
monoamine 3 99.78 Very High Very High Very High
Dopamine 14 99.56 Very High Very High Very High
Morphine 1 99.32 Very High Very High Very High
ischemia 1 99.00 Very High Very High Very High
Enkephalin 13 97.92 Very High Very High Very High
aspirin 13 97.32 Very High Very High Very High
opiate 1 96.92 Very High Very High Very High
Clonidine 2 94.24 High High
narcan 3 93.92 High High
antagonist 1 93.56 High High
Disease Link Frequency Relevance Heat
Parkinson's Disease 57 100.00 Very High Very High Very High
Toxicity 5 99.96 Very High Very High Very High
Ganglion Cysts 6 99.60 Very High Very High Very High
Alzheimer's Dementia 1 99.38 Very High Very High Very High
Cv General 4 Under Development 1 99.00 Very High Very High Very High
Drug Induced Neurotoxicity 11 98.12 Very High Very High Very High
Stress 13 97.80 Very High Very High Very High
Brain Injury 7 97.40 Very High Very High Very High
Aging 1 97.12 Very High Very High Very High
Parkinsonian Disorders 1 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
L-dopa/carbidopa protected NPY neurons against MPTP but slightly enhanced MPTP-induced decrease in the levels of dopamine and its metabolites.
Negative_regulation (decrease) of MPTP-induced in neurons associated with parkinson's disease and dopamine
1) Confidence 0.37 Published 2003 Journal J Neural Transm Section Abstract Doc Link 14666410 Disease Relevance 0.61 Pain Relevance 0.48
Like meperidine and morphine, the ganglion-blocking action of MPTP was reduced when the concentration of Ca2+ in the Locke solution was elevated.
Negative_regulation (reduced) of MPTP in ganglion associated with parkinson's disease, ganglion cysts and morphine
2) Confidence 0.28 Published 1992 Journal J Auton Pharmacol Section Abstract Doc Link 1313036 Disease Relevance 1.19 Pain Relevance 0.60
[Effects of monoamine oxidase B inhibitor and MPTP (1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine) on enkephalin levels in mice].
Negative_regulation (inhibitor) of MPTP associated with parkinson's disease, enkephalin and monoamine
3) Confidence 0.27 Published 1990 Journal Zhonghua Shen Jing Jing Shen Ke Za Zhi Section Title Doc Link 2118063 Disease Relevance 0.53 Pain Relevance 0.96
The neurotoxic effects of the dopamine-selective neurotoxin MPTP (15 mg/kg, s.c.), in mice, were totally prevented by systemic administration of salicylate (ED50 = 40 mg/kg, i.p.), aspirin (ED50 = 60 mg/kg, i.p.), or the soluble lysine salt of aspirin, Aspegic (ED50 = 80 mg/kg, i.p.).
Negative_regulation (prevented) of MPTP associated with parkinson's disease, aspirin and dopamine
4) Confidence 0.23 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9751197 Disease Relevance 0.17 Pain Relevance 0.50
In the absence of MPTP, TGFbeta1 greatly decreased the number of dopaminergic neurons in the ventral mesencephalon of fully mature mice.
Negative_regulation (absence) of MPTP in mesencephalon associated with parkinson's disease
5) Confidence 0.23 Published 2003 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 12932441 Disease Relevance 0.72 Pain Relevance 0.22
In this investigation an attempt was made to determine a possible protective effect of quinacrine (QNC), a PLA2 inhibitor on MPTP as well as 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in rodents.
Spec (possible) Negative_regulation (inhibitor) of MPTP associated with parkinson's disease and drug induced neurotoxicity
6) Confidence 0.13 Published 2001 Journal Brain Res. Bull. Section Abstract Doc Link 11226716 Disease Relevance 0.77 Pain Relevance 0.10
The opening of the mitochondrial permeability transition pore (MPTP) is inhibited by CsA, thereby maintaining the mitochondrial membrane potential and calcium homeostasis in isolated mitochondrial.
Negative_regulation (inhibited) of MPTP in MPTP associated with parkinson's disease
7) Confidence 0.02 Published 1999 Journal Exp. Neurol. Section Abstract Doc Link 10630207 Disease Relevance 1.06 Pain Relevance 0.09
In addition, aconitase inactivation has been observed in various animal and cell models of neuronal disorders and oxidative stress [32], [33] including excitotoxicity [17], cerebral ischemia [34], beta-amyloid toxicity [35], oxygen-glucose deprivation [30], MPTP toxicity [16], Sod2 and DJ1 mutant mice [18], [36], [37] as well as in aging [38], [39].
Negative_regulation (deprivation) of MPTP in neuronal associated with parkinson's disease, stress, toxicity, aging, cv general 4 under development, ischemia and alzheimer's dementia
8) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738973 Disease Relevance 1.58 Pain Relevance 0.14

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