INT56481

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Context Info
Confidence 0.05
First Reported 1993
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.25
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Lrpap1) plasma membrane (Lrpap1) cytoplasm (Lrpap1)
Anatomy Link Frequency
central nervous system 1
Lrpap1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 4 99.36 Very High Very High Very High
Central nervous system 3 96.20 Very High Very High Very High
Clonidine 2 86.32 High High
medulla 2 82.96 Quite High
adenocard 2 75.00 Quite High
Calcium channel 1 62.28 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 15 99.66 Very High Very High Very High
Hypertension 5 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The differential effects of pertussis toxin in the metabolic actions of phenylephrine and vasopressin, in spite of apparently similar effects in perturbing their actions on Ca2+ fluxes, suggest that pertussis toxin-sensitive alpha 1-receptor-associated G protein(s) other than those controlling Ca2+ channels, were also specifically affected in the alpha 1-agonist-signaling pathway.
Regulation (affected) of alpha 1-receptor-associated associated with bordatella infection and agonist
1) Confidence 0.05 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8095934 Disease Relevance 0.76 Pain Relevance 0.21
The results of the present study showed that the alteration in the presynaptic alpha2-receptor-protein kinase A system might actively participate in the regulation of norepinephrine release in the central nervous system in hypertension.
Regulation (alteration) of alpha2-receptor-protein in central nervous system associated with hypertension and central nervous system
2) Confidence 0.02 Published 2003 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 14871035 Disease Relevance 0.49 Pain Relevance 0.36

General Comments

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