INT5649

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Context Info
Confidence 0.59
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 31
Total Number 32
Disease Relevance 26.62
Pain Relevance 11.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mpo) extracellular space (Mpo) aging (Mpo)
Anatomy Link Frequency
visceral 2
plasma 2
PGE1 2
aorta 2
liver 2
Mpo (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 34 100.00 Very High Very High Very High
aspirin 20 100.00 Very High Very High Very High
dexamethasone 1 99.98 Very High Very High Very High
Calcitonin gene-related peptide 5 99.48 Very High Very High Very High
MU agonist 2 99.46 Very High Very High Very High
nud 4 99.44 Very High Very High Very High
Inflammation 101 99.20 Very High Very High Very High
Hyperalgesia 2 99.16 Very High Very High Very High
cINOD 14 98.72 Very High Very High Very High
tolerance 1 98.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 146 100.00 Very High Very High Very High
Urological Neuroanatomy 134 100.00 Very High Very High Very High
Stress 52 100.00 Very High Very High Very High
Body Weight 42 100.00 Very High Very High Very High
Weight Gain 1 100.00 Very High Very High Very High
Injury 75 99.98 Very High Very High Very High
Dyspepsia 4 99.44 Very High Very High Very High
INFLAMMATION 127 99.20 Very High Very High Very High
Hyperalgesia 23 99.16 Very High Very High Very High
Ulcers 10 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gastric LPO and MPO activity that were increased significantly by ASA were decreased after treatment with omeprazole, famotidine, and melatonin.
Negative_regulation (decreased) of Positive_regulation (increased) of MPO associated with aspirin and urological neuroanatomy
1) Confidence 0.59 Published 2001 Journal Dig. Dis. Sci. Section Abstract Doc Link 11281181 Disease Relevance 0.46 Pain Relevance 0.43
Furthermore, both drugs greatly reduced (P<0.01) the associated increases in myeloperoxidase levels and lipid peroxidation induced by indomethacin, whereas they only moderately affected (P<0.05) the translocation of enterobacteria from lumen into the intestinal mucosa.
Negative_regulation (reduced) of Positive_regulation (increases) of myeloperoxidase in lumen
2) Confidence 0.59 Published 2007 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 17151854 Disease Relevance 0.20 Pain Relevance 0.26
The development of intestinal lesions in response to indomethacin was dose-dependently prevented by lansoprazole at a dose of 5 mg/kg together with significant suppression of the increased level of TBARS, MPO activities and CINC-1 in the small bowel.
Negative_regulation (suppression) of Positive_regulation (increased) of MPO in bowel associated with urological neuroanatomy
3) Confidence 0.58 Published 2006 Journal Int. J. Mol. Med. Section Abstract Doc Link 16328016 Disease Relevance 0.64 Pain Relevance 0.25
Pretreatment with melatonin (10 mg/kg) decreased the MDA levels significantly, restored the PC levels to the control, prevented the increase of nitrite level and MPO activity significantly and reversed to the control levels, prevented the reduction in all of the antioxidant enzyme activities.
Negative_regulation (prevented) of Positive_regulation (increase) of MPO associated with urological neuroanatomy
4) Confidence 0.58 Published 2007 Journal J. Pineal Res. Section Abstract Doc Link 17614834 Disease Relevance 0.64 Pain Relevance 0.14
Finally, the treatment with hexanic extract inhibited the increase of myeloperoxidase activity, either following intraplantar injection of CFA or after sciatic nerve injury.
Negative_regulation (inhibited) of Positive_regulation (increase) of myeloperoxidase in sciatic nerve associated with nervous system injury and sciatic nerve
5) Confidence 0.57 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14575799 Disease Relevance 1.36 Pain Relevance 0.99
We found that (1) capsaicin denervation blocked stress-induced increase of visceral sensitivity, while doxantrazole presented a partial blocking; (2) capsaicin denervation blocked stress-induced enhancement of the proximity of mast cell-nerve fiber-blood vessels and blood vessel damage, while doxantrazole showed no effects on these; (3) doxantrazole blocked stress-induced increases of the MPO activity, the number and the degranulation of mast cells in the colon; (4) sensory denervation and doxantrazole had no effects on stress-induced behavioral inhibition.
Negative_regulation (blocked) of Positive_regulation (increases) of MPO in visceral associated with stress, qutenza and urological neuroanatomy
6) Confidence 0.43 Published 2009 Journal Dig. Dis. Sci. Section Abstract Doc Link 19051028 Disease Relevance 0.87 Pain Relevance 0.46
Likewise, it could be expected that systemic treatment using drugs of established mechanisms of action, such as celecoxib and morphine, a selective nonsteroidal anti-inflammatory drug [23], and a classical opioid agonist, respectively, would also reverse the detected increase in MPO activity.
Negative_regulation (reverse) of Positive_regulation (increase) of MPO associated with mu agonist, inflammation, cinod, urological neuroanatomy and morphine
7) Confidence 0.43 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2804053 Disease Relevance 1.06 Pain Relevance 0.60
Rosiglitazone also attenuated tibial and sural nerve transection-induced increase in oxidative stress, myeloperoxidase activity and calcium levels.
Negative_regulation (attenuated) of Positive_regulation (increase) of myeloperoxidase in nerve associated with stress
8) Confidence 0.43 Published 2009 Journal Pharmacol. Res. Section Abstract Doc Link 19429470 Disease Relevance 0.83 Pain Relevance 0.77
Morphine pretreatment (2 or 8 mg/kg, given intraperitoneally) at the time of stress dose-dependently reversed stress-induced gastric ulceration, increase of myeloperoxidase activity and reduction of thickness of mucus-stained cells in the gastric mucosa.
Negative_regulation (reversed) of Positive_regulation (increase) of myeloperoxidase associated with stress and morphine
9) Confidence 0.43 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12559379 Disease Relevance 1.41 Pain Relevance 0.73
The increases of thiobarbituric acid-reactive substances (TBA-RS) and myeloperoxidase (MPO) activity 3 h after aspirin administration were significantly inhibited by pretreatment with TMG.
Negative_regulation (inhibited) of Positive_regulation (increases) of myeloperoxidase associated with aspirin and urological neuroanatomy
10) Confidence 0.43 Published 2005 Journal Int. J. Mol. Med. Section Abstract Doc Link 16273283 Disease Relevance 0.71 Pain Relevance 0.59
The development of intestinal lesions in response to indomethacin was prevented in Ws/Ws rats compared with W+/W+ rats, together with significant suppression of the increased levels of TBARS, MPO activities, and CINC-1 levels.
Negative_regulation (suppression) of Positive_regulation (increased) of MPO
11) Confidence 0.43 Published 2009 Journal J. Gastroenterol. Section Body Doc Link 19148791 Disease Relevance 0.07 Pain Relevance 0
HCl-induced lesions, MPO activity, TBARS, and plasma NOx production were decreased by AG.
Negative_regulation (decreased) of Positive_regulation (induced) of MPO in plasma associated with urological neuroanatomy
12) Confidence 0.43 Published 2001 Journal J. Lab. Clin. Med. Section Abstract Doc Link 11574821 Disease Relevance 1.13 Pain Relevance 0
The hydroalcoholic extract (200 mg/kg) substantially reduced MPO activity (P < 0.05), which was increased in the control group.
Negative_regulation (reduced) of Positive_regulation (increased) of MPO associated with urological neuroanatomy
13) Confidence 0.43 Published 2001 Journal J Ethnopharmacol Section Abstract Doc Link 11297854 Disease Relevance 0.89 Pain Relevance 0.32
Both lafutidine and capsaicin significantly suppressed the increases in MPO and iNOS activities as well as enterobacterial numbers in the mucosa.
Negative_regulation (suppressed) of Positive_regulation (increases) of MPO
14) Confidence 0.43 Published 2000 Journal Digestion Section Body Doc Link 10671773 Disease Relevance 0.06 Pain Relevance 0
Pretreatment with melatonin (10 mg/kg) decreased the MDA levels significantly, restored the PC levels to the control, prevented the increase of nitrite level and MPO activity significantly and reversed to the control levels, prevented the reduction in all of the antioxidant enzyme activities.
Negative_regulation (reversed) of Positive_regulation (increase) of MPO associated with urological neuroanatomy
15) Confidence 0.43 Published 2007 Journal J. Pineal Res. Section Abstract Doc Link 17614834 Disease Relevance 0.65 Pain Relevance 0.14
Heat pretreatment did not prevent the increase in myeloperoxidase activity in septic rats (Fig. 2).


Negative_regulation (prevent) of Positive_regulation (increase) of myeloperoxidase
16) Confidence 0.42 Published 2000 Journal Crit Care Section Body Doc Link PMC29035 Disease Relevance 0.13 Pain Relevance 0.08
Repeated stress insults reduced stress-induced gastric damage, NO production and MPO activity, with an increase in PGE2 and CGRP levels compared with rats exposed to single cold restraint stress.
Negative_regulation (reduced) of Positive_regulation (increase) of MPO associated with stress, urological neuroanatomy and calcitonin gene-related peptide
17) Confidence 0.42 Published 2006 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 17002672 Disease Relevance 1.07 Pain Relevance 0.54
Colchicine (0.3 and 1 mg/kg) attenuated the NGF (0.8 and 4 microg)-induced increase in tissue myeloperoxidase (MPO) as determined 6 h after NGF application.
Negative_regulation (attenuated) of Positive_regulation (increase) of MPO associated with nerve growth factor and urological neuroanatomy
18) Confidence 0.41 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9750013 Disease Relevance 0.89 Pain Relevance 0.96
We conclude that the infusion of PGE1 30 ng.kg-1.min-1 failed to inhibit the increase of GEL as well as MPO, and the decrease of ACE.
Negative_regulation (inhibit) of Positive_regulation (increase) of MPO in PGE1 associated with urological neuroanatomy
19) Confidence 0.41 Published 1992 Journal Masui Section Abstract Doc Link 1313120 Disease Relevance 0.31 Pain Relevance 0.07
Octacosanol (10, 50 or 100 mg/kg BW) administered orally at an early stage of CCl4-induced liver injury reduced the increase in hepatic MPO activity found at a progressed stage of the injury in a dose-dependent manner.
Negative_regulation (reduced) of Positive_regulation (increase) of MPO in liver associated with body weight, injury and urological neuroanatomy
20) Confidence 0.39 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266062 Disease Relevance 1.47 Pain Relevance 0.07

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