INT56492

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Context Info
Confidence 0.49
First Reported 1993
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.95
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGAX) plasma membrane (ITGAX)
Anatomy Link Frequency
macrophages 1
T cells 1
ITGAX (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 261 100.00 Very High Very High Very High
Inflammation 36 75.00 Quite High
Neuritis 1 73.32 Quite High
fibrosis 1 67.04 Quite High
cytokine 42 26.32 Quite Low
chemokine 12 6.88 Low Low
Pain 6 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
spinal inflammation 3 5.00 Very Low Very Low Very Low
psoriasis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 261 100.00 Very High Very High Very High
Death 3 97.60 Very High Very High Very High
Systemic Lupus Erythematosus 9 92.08 High High
INFLAMMATION 34 75.00 Quite High
Abdominal Aortic Aneurysm 4 75.00 Quite High
Neuritis 1 73.32 Quite High
Increased Venous Pressure Under Development 3 72.92 Quite High
Fibrosis 1 67.04 Quite High
Arthritis 3 39.64 Quite Low
Disease 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some of the macrophages were also activated (CD4+/CD11c+/CD25+/CD30-).
Positive_regulation (activated) of CD11c in macrophages
1) Confidence 0.49 Published 1993 Journal J. Submicrosc. Cytol. Pathol. Section Abstract Doc Link 8096431 Disease Relevance 0.89 Pain Relevance 0.24
In contrast, both freshly isolated CD11c+ and CD123+ SF DCs efficiently stimulated proliferation and IFN-?
Positive_regulation (isolated) of CD11c
2) Confidence 0.22 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 0.40 Pain Relevance 0.15
To analyse the functional capability of RA SF DCs, CD11c+ and CD123+ DCs were sorted from either normal PB or RA SF and incubated with freshly isolated normal allogeneic PB T cells.
Positive_regulation (incubated) of CD11c in T cells associated with rheumatoid arthritis
3) Confidence 0.22 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 0.40 Pain Relevance 0.16
RA SF contained a significantly greater percentage of CD11c+ DCs than normal or RA PB (P < 0.005) – in accord with previous studies using the markers CD33 and CD14 [40].
Positive_regulation (percentage) of CD11c associated with rheumatoid arthritis
4) Confidence 0.22 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 1.27 Pain Relevance 0.59

General Comments

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