INT56493

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Context Info
Confidence 0.47
First Reported 1993
Last Reported 2009
Negated 1
Speculated 2
Reported most in Body
Documents 15
Total Number 17
Disease Relevance 3.53
Pain Relevance 3.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ide) mitochondrion (Ide) extracellular space (Ide)
ATPase activity (Ide) nucleus (Ide)
Anatomy Link Frequency
pancreatic islets 6
blood 2
plasma 2
endocrine cells 2
brain 2
Ide (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 85 100.00 Very High Very High Very High
monoamine 52 100.00 Very High Very High Very High
Clonidine 12 98.96 Very High Very High Very High
Serotonin 8 98.92 Very High Very High Very High
agonist 82 98.24 Very High Very High Very High
antagonist 15 92.16 High High
Prostatitis 1 86.20 High High
Dopamine 4 81.36 Quite High
Neuropeptide 2 80.60 Quite High
adenocard 9 53.08 Quite High
Disease Link Frequency Relevance Heat
Impaired Glucose Tolerance 99 100.00 Very High Very High Very High
Hyperinsulinism 17 99.04 Very High Very High Very High
Obesity 64 94.80 High High
Wound Healing 15 93.72 High High
Body Weight 110 92.24 High High
Sprains And Strains 4 87.60 High High
Reprotox - General 1 1 86.20 High High
Nephritis 1 85.56 High High
Kidney Stones 1 85.16 High High
Crystal Associated Disease 1 84.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, injection of the non-selective alpha-adrenoceptor agonist, adrenaline, which unlike clonidine does not penetrate the blood-brain barrier, had no effect on insulin release induced by a maximal dose of the nonselective beta-adrenoceptor agonist, isoprenaline.
Neg (no) Regulation (effect) of Localization (release) of insulin in brain associated with agonist and clonidine
1) Confidence 0.47 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8096820 Disease Relevance 0 Pain Relevance 1.01
Effects of adrenergic and cholinergic stimulation on islet monoamine oxidase activity and insulin secretion in the mouse.
Regulation (Effects) of Localization (secretion) of insulin associated with monoamine
2) Confidence 0.47 Published 1993 Journal Eur. J. Pharmacol. Section Title Doc Link 8096820 Disease Relevance 0 Pain Relevance 0.78
Altogether, these results show that the P2Y1 receptor plays a physiological role in the maintenance of glucose homeostasis at least in part by regulating insulin secretion.



Regulation (regulating) of Localization (secretion) of insulin
3) Confidence 0.35 Published 2005 Journal Purinergic Signal Section Abstract Doc Link PMC2096536 Disease Relevance 0.14 Pain Relevance 0
To determine whether the P2Y1 receptor was directly involved in the control of insulin secretion, experiments were carried out in isolated Langerhans islets.
Spec (whether) Regulation (involved) of Localization (secretion) of insulin
4) Confidence 0.35 Published 2005 Journal Purinergic Signal Section Abstract Doc Link PMC2096536 Disease Relevance 0.17 Pain Relevance 0
cells express several P2 receptors including P2Y1 and the modulation of insulin secretion by extracellular nucleotides has suggested that these receptors may contribute to the regulation of glucose homeostasis.
Regulation (modulation) of Localization (secretion) of insulin
5) Confidence 0.35 Published 2005 Journal Purinergic Signal Section Abstract Doc Link PMC2096536 Disease Relevance 0.13 Pain Relevance 0
This receptor may thus function as an autocrine loop for the feedback control of insulin secretion through release of ADP stored in insulin granules, thereby allowing the b cells to rapidly adapt their response to variations in plasma glucose.
Regulation (control) of Localization (secretion) of insulin in plasma
6) Confidence 0.35 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.20 Pain Relevance 0.03
The P2Y1 receptor is involved in the maintenance of glucose homeostasis and in insulin secretion in mice

Pancreatic ?

Regulation (involved) of Localization (secretion) of insulin
7) Confidence 0.35 Published 2005 Journal Purinergic Signal Section Title Doc Link PMC2096536 Disease Relevance 0.16 Pain Relevance 0
These effects on insulin secretion and monoamine oxidase activity could not be blocked by clonidine.
Regulation (effects) of Localization (secretion) of insulin associated with clonidine and monoamine
8) Confidence 0.34 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8096820 Disease Relevance 0 Pain Relevance 1.02
It has been shown that the pancreatic beta-cell monoamines are located in the secretory granules, and that they have an inhibitory influence on insulin secretion.
Regulation (influence) of Localization (secretion) of insulin associated with monoamine
9) Confidence 0.21 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8096820 Disease Relevance 0 Pain Relevance 0.52
In vitro experiments in isolated pancreatic islets showed an increased insulin secretion in P2Y1-deficient mice, suggesting a role of the P2Y1 receptor in the maintenance of glucose homeostasis and in the regulation of insulin secretion.


Regulation (role) of Localization (secretion) of insulin in pancreatic islets associated with hyperinsulinism
10) Confidence 0.16 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.31 Pain Relevance 0.06
The role of extracellular nucleotides in the modulation of pancreatic insulin secretion is well known [24–26].
Regulation (modulation) of Localization (secretion) of insulin
11) Confidence 0.16 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0 Pain Relevance 0.04
To determine whether the P2Y1 receptor was directly involved in the control of insulin secretion, experiments were carried out in isolated Langerhans islets.
Spec (whether) Regulation (control) of Localization (secretion) of insulin
12) Confidence 0.16 Published 2005 Journal Purinergic Signal Section Abstract Doc Link PMC2096536 Disease Relevance 0.17 Pain Relevance 0
In vitro experiments in isolated pancreatic islets showed an increased insulin secretion in P2Y1-deficient mice, suggesting a role of the P2Y1 receptor in the maintenance of glucose homeostasis and in the regulation of insulin secretion.


Regulation (regulation) of Localization (secretion) of insulin in pancreatic islets associated with hyperinsulinism
13) Confidence 0.16 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.30 Pain Relevance 0.03
Whereas most of the glucose-lowering actions of GLP-1 have been attributed to the direct effect of the hormone on the endocrine pancreas, i.e., to stimulation of insulin and inhibition of glucagon secretion, we demonstrated the importance of extra-pancreatic GLP-1 receptor–dependent control of insulin secretion (11) and whole-body glucose distribution (12).
Regulation (control) of Localization (secretion) of insulin in endocrine pancreas
14) Confidence 0.09 Published 2008 Journal Diabetes Section Body Doc Link PMC2551665 Disease Relevance 0.17 Pain Relevance 0.13
The effects of corn silk on blood glucose, HbA1c, insulin secretion, damaged pancreatic ?
Regulation (effects) of Localization (secretion) of insulin in blood
15) Confidence 0.08 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2785813 Disease Relevance 0.80 Pain Relevance 0.09
Effect of BVT116429 on glucose tolerance and insulin sensitivity
Regulation (Effect) of Localization (sensitivity) of insulin associated with tolerance and impaired glucose tolerance
16) Confidence 0.05 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 0.51 Pain Relevance 0.12
In the pancreas, NCoA6 is expressed in the endocrine cells of islets of langerhans and thus the role of NCoA6(ASC-2) in insulin secretion from pancreatic ?
Regulation (role) of Localization (secretion) of insulin in endocrine cells
17) Confidence 0.01 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.48 Pain Relevance 0

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