INT56494

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Context Info
Confidence 0.68
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 73
Total Number 73
Disease Relevance 22.90
Pain Relevance 11.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ide) mitochondrion (Ide) extracellular space (Ide)
ATPase activity (Ide) nucleus (Ide)
Anatomy Link Frequency
pancreatic islets 6
pancreas 5
brain 3
blood 3
Beta cell 2
Ide (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 227 99.90 Very High Very High Very High
monoamine 117 99.84 Very High Very High Very High
antagonist 58 99.46 Very High Very High Very High
agonist 323 99.40 Very High Very High Very High
Clonidine 27 98.76 Very High Very High Very High
Serotonin 18 98.48 Very High Very High Very High
glial activation 1 96.28 Very High Very High Very High
member 8 24 93.16 High High
vagus nerve 82 92.00 High High
Dopamine 9 89.92 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 551 100.00 Very High Very High Very High
Hyperinsulinism 61 100.00 Very High Very High Very High
Diabetes Mellitus-type I 4 100.00 Very High Very High Very High
Impaired Glucose Tolerance 258 99.90 Very High Very High Very High
Hypoglycemia 27 99.74 Very High Very High Very High
Hyperglycemia 139 99.72 Very High Very High Very High
Generalized Anxiety Disorder 12 99.72 Very High Very High Very High
Insulin Resistance 132 99.70 Very High Very High Very High
Fetal Weight 1 99.44 Very High Very High Very High
Metabolic Disorder 12 99.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These reports also support a view that exogenous insulin administration may have a reflex action over the secretion of insulin from pancreas in healthy animals.
Localization (secretion) of insulin in pancreas
1) Confidence 0.68 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.09 Pain Relevance 0
The elevated serum insulin levels observed with higher doses of insulin might be due to insulin administration itself or a reflex release of endogenous insulin from the pancreas.
Localization (release) of insulin in pancreas
2) Confidence 0.68 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.08 Pain Relevance 0
The elevated serum insulin levels observed with higher doses of insulin might be due to insulin administration itself or a reflex release of endogenous insulin from the pancreas.
Localization (release) of insulin in pancreas
3) Confidence 0.63 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.08 Pain Relevance 0
C-peptide is released in equimolar ratio with insulin from islet cells and is not extracted by liver [27].
Localization (released) of insulin in liver
4) Confidence 0.63 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.09 Pain Relevance 0
The elevated serum insulin levels observed with higher doses of insulin might be due to insulin administration itself or a reflex release of endogenous insulin from the pancreas.
Localization (release) of insulin in pancreas
5) Confidence 0.63 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.08 Pain Relevance 0
Administration of Insulin
Localization (Administration) of Insulin
6) Confidence 0.63 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0 Pain Relevance 0
Measurement of serum insulin and C-peptide of insulin
Localization (Measurement) of insulin
7) Confidence 0.63 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0 Pain Relevance 0
Measurement of serum insulin and C-peptide of insulin
Localization (Measurement) of insulin
8) Confidence 0.63 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0 Pain Relevance 0
These effects on insulin secretion and monoamine oxidase activity could not be blocked by clonidine.
Localization (secretion) of insulin associated with clonidine and monoamine
9) Confidence 0.61 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8096820 Disease Relevance 0 Pain Relevance 1.01
A marked insulin release following the injection of a maximal dose of the beta 2-adrenoceptor agonist, terbutaline, was accompanied by an increase (30-50%) in islet monoamine oxidase activity.
Localization (release) of insulin associated with agonist and monoamine
10) Confidence 0.61 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8096820 Disease Relevance 0 Pain Relevance 0.96
It has been shown that the pancreatic beta-cell monoamines are located in the secretory granules, and that they have an inhibitory influence on insulin secretion.
Localization (secretion) of insulin associated with monoamine
11) Confidence 0.61 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8096820 Disease Relevance 0 Pain Relevance 0.51
Effects of adrenergic and cholinergic stimulation on islet monoamine oxidase activity and insulin secretion in the mouse.
Localization (secretion) of insulin associated with monoamine
12) Confidence 0.61 Published 1993 Journal Eur. J. Pharmacol. Section Title Doc Link 8096820 Disease Relevance 0 Pain Relevance 0.78
Similarly, injection of the non-selective alpha-adrenoceptor agonist, adrenaline, which unlike clonidine does not penetrate the blood-brain barrier, had no effect on insulin release induced by a maximal dose of the nonselective beta-adrenoceptor agonist, isoprenaline.
Localization (release) of insulin in brain associated with agonist and clonidine
13) Confidence 0.61 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8096820 Disease Relevance 0 Pain Relevance 1.00
Cholinergic muscarinic stimulation by a maximal insulin releasing dose of carbachol did not affect islet monoamine oxidase activity.
Localization (releasing) of insulin associated with monoamine
14) Confidence 0.61 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8096820 Disease Relevance 0 Pain Relevance 0.88
Adrenaline, however, markedly suppressed the insulin release induced by a maximal dose of glucose.
Localization (release) of insulin
15) Confidence 0.61 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8096820 Disease Relevance 0 Pain Relevance 0.91
We now studied in vivo the relation between adrenergic and cholinergic stimulation, insulin secretion and islet monoamine oxidase activity in the mouse.
Localization (secretion) of insulin associated with monoamine
16) Confidence 0.61 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8096820 Disease Relevance 0 Pain Relevance 0.62
The results suggest that beta 2-adrenoceptor stimulation of islet monoamine oxidase activity reduced the monoamine content and thereby facilitated the release of insulin.
Localization (release) of insulin associated with monoamine
17) Confidence 0.61 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8096820 Disease Relevance 0 Pain Relevance 0.64
Garvey et al [25] reported about an improvement of endogenous insulin secretion after exogenous insulin injection.
Localization (secretion) of insulin
18) Confidence 0.59 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.09 Pain Relevance 0
Garvey et al [25] reported about an improvement of endogenous insulin secretion after exogenous insulin injection.
Localization (secretion) of insulin
19) Confidence 0.59 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.09 Pain Relevance 0
and hAChE peptides are in common and are as follows; His12-Trp13 and Trp13-Lys14 for IDE, and Ser8-Tyr9 for NEP (AChE586-599 peptide numbering)(Figure S2 supporting information).
Localization (follows) of IDE
20) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0 Pain Relevance 0

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