INT56495

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Context Info
Confidence 0.53
First Reported 1993
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 20
Total Number 23
Disease Relevance 3.53
Pain Relevance 4.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ide) mitochondrion (Ide) extracellular space (Ide)
ATPase activity (Ide) nucleus (Ide)
Anatomy Link Frequency
pancreas 8
pancreatic islets 4
brain 4
blood 2
beta cells 2
Ide (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 213 100.00 Very High Very High Very High
monoamine 52 99.58 Very High Very High Very High
antagonist 36 99.46 Very High Very High Very High
Clonidine 12 98.76 Very High Very High Very High
vagus nerve 65 92.40 High High
tolerance 57 90.44 High High
Serotonin 8 89.52 High High
Dopamine 4 86.84 High High
Neuropeptide 10 74.08 Quite High
Intracerebroventricular 40 48.24 Quite Low
Disease Link Frequency Relevance Heat
Hyperinsulinism 31 100.00 Very High Very High Very High
Hypoglycemia 15 99.92 Very High Very High Very High
Insulin Resistance 38 99.90 Very High Very High Very High
Fetal Weight 1 99.44 Very High Very High Very High
Diabetes Mellitus 135 95.64 Very High Very High Very High
Body Weight 78 94.84 High High
Necrosis 2 94.12 High High
Gestational Diabetes 10 92.96 High High
Birth Weight 3 91.84 High High
Impaired Glucose Tolerance 69 90.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, injection of the non-selective alpha-adrenoceptor agonist, adrenaline, which unlike clonidine does not penetrate the blood-brain barrier, had no effect on insulin release induced by a maximal dose of the nonselective beta-adrenoceptor agonist, isoprenaline.
Positive_regulation (induced) of Localization (release) of insulin in brain associated with agonist and clonidine
1) Confidence 0.53 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8096820 Disease Relevance 0 Pain Relevance 1.00
Adrenaline, however, markedly suppressed the insulin release induced by a maximal dose of glucose.
Positive_regulation (induced) of Localization (release) of insulin
2) Confidence 0.53 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8096820 Disease Relevance 0 Pain Relevance 0.91
The elevated serum insulin levels observed with higher doses of insulin might be due to insulin administration itself or a reflex release of endogenous insulin from the pancreas.
Spec (might) Positive_regulation (due) of Localization (release) of insulin in pancreas
3) Confidence 0.42 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.08 Pain Relevance 0
These reports also support a view that exogenous insulin administration may have a reflex action over the secretion of insulin from pancreas in healthy animals.
Positive_regulation (pancreas) of Localization (secretion) of insulin in pancreas
4) Confidence 0.42 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.09 Pain Relevance 0
The elevated serum insulin levels observed with higher doses of insulin might be due to insulin administration itself or a reflex release of endogenous insulin from the pancreas.
Spec (might) Positive_regulation (due) of Localization (release) of insulin in pancreas
5) Confidence 0.42 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.08 Pain Relevance 0
The elevated serum insulin levels observed with higher doses of insulin might be due to insulin administration itself or a reflex release of endogenous insulin from the pancreas.
Spec (might) Positive_regulation (due) of Localization (release) of insulin in pancreas
6) Confidence 0.42 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.08 Pain Relevance 0
All these data disagree with our observation that absence of the P2Y1 receptor contributes to increase insulin secretion instead of decreasing it.
Positive_regulation (contributes) of Localization (secretion) of insulin
7) Confidence 0.40 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0 Pain Relevance 0.09
The results suggest that beta 2-adrenoceptor stimulation of islet monoamine oxidase activity reduced the monoamine content and thereby facilitated the release of insulin.
Positive_regulation (facilitated) of Localization (release) of insulin associated with monoamine
8) Confidence 0.38 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8096820 Disease Relevance 0 Pain Relevance 0.64
Garvey et al [25] reported about an improvement of endogenous insulin secretion after exogenous insulin injection.
Positive_regulation (improvement) of Localization (secretion) of insulin
9) Confidence 0.37 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.09 Pain Relevance 0
A marked insulin release following the injection of a maximal dose of the beta 2-adrenoceptor agonist, terbutaline, was accompanied by an increase (30-50%) in islet monoamine oxidase activity.
Positive_regulation (accompanied) of Localization (release) of insulin associated with agonist and monoamine
10) Confidence 0.35 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8096820 Disease Relevance 0 Pain Relevance 1.00
Similar observations were reported more recently [32], and the authors showed that nucleotides had an inhibitory action on insulin secretion through direct interference with the secretory machinery by activation of the protein phosphatase calcineurin.
Positive_regulation (activation) of Localization (secretion) of insulin
11) Confidence 0.29 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.06 Pain Relevance 0.07
Insulin secretion in isolated pancreatic islets
Positive_regulation (pancreatic islets) of Localization (secretion) of Insulin in pancreatic islets
12) Confidence 0.29 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.06 Pain Relevance 0.03
cells express a wide range of P2 receptors including P2Y subtypes [14], while stable analogues of ATP and ADP have been shown to increase insulin secretion and decrease glycemia in vivo [15].
Positive_regulation (increase) of Localization (secretion) of insulin
13) Confidence 0.27 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.16 Pain Relevance 0.09
In vitro experiments in isolated pancreatic islets showed an increased insulin secretion in P2Y1-deficient mice, suggesting a role of the P2Y1 receptor in the maintenance of glucose homeostasis and in the regulation of insulin secretion.


Positive_regulation (increased) of Localization (secretion) of insulin in pancreatic islets associated with hyperinsulinism
14) Confidence 0.27 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.30 Pain Relevance 0.06
All these data disagree with our observation that absence of the P2Y1 receptor contributes to increase insulin secretion instead of decreasing it.
Positive_regulation (increase) of Localization (secretion) of insulin
15) Confidence 0.27 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0 Pain Relevance 0.09
After the mice were orally administered with corn silk extract, the blood glucose and the HbA1c were significantly decreased in alloxan-induced hyperglycemic mice (p < 0.05, p < 0.01, respectively), while the level of insulin secretionn was markedly elevated in alloxa-induced hyperglycemic mice (p < 0.05).
Positive_regulation (elevated) of Localization (secretionn) of insulin in blood
16) Confidence 0.14 Published 2009 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2785813 Disease Relevance 0.08 Pain Relevance 0
On the other hand, alloxan has two distinct pathological effects: it selectively inhibits glucose-induced insulin secretion through specific inhibition of glucokinase, the glucose sensor of the beta cell, and it causes a state of insulin-dependent diabetes by selective necrosis of beta cells in type 1 and type 2 diabetes mellitus [24-26].
Positive_regulation (induced) of Localization (secretion) of insulin in beta cells associated with necrosis and diabetes mellitus
17) Confidence 0.14 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2785813 Disease Relevance 0.88 Pain Relevance 0
Our study would suggest that this may not be explained solely by maternal genetic and environmental factors determining glucose concentrations crossing the placenta and stimulating fetal insulin secretion with ensuing fetal weight gain.
Positive_regulation (stimulating) of Localization (secretion) of insulin in placenta associated with fetal weight
18) Confidence 0.11 Published 2010 Journal Diabetes Section Body Doc Link PMC2797934 Disease Relevance 0.71 Pain Relevance 0.07
Conversely, central administration of the GLP-1 receptor agonist exendin-4 (Ex4) augmented intravenous glucose-stimulated insulin secretion to a level similar to that obtained during an intragastric glucose infusion (11).
Positive_regulation (augmented) of Localization (secretion) of insulin associated with agonist
19) Confidence 0.10 Published 2008 Journal Diabetes Section Body Doc Link PMC2551665 Disease Relevance 0.08 Pain Relevance 0.13
The infusion into the brain of the GLP-1 receptor antagonist exendin-9 (Ex9) inhibited insulin secretion induced by gut glucose (11).
Positive_regulation (induced) of Localization (secretion) of insulin in gut associated with antagonist
20) Confidence 0.10 Published 2008 Journal Diabetes Section Body Doc Link PMC2551665 Disease Relevance 0.17 Pain Relevance 0.13

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