INT56497

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Context Info
Confidence 0.44
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 5.34
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ide) mitochondrion (Ide) extracellular space (Ide)
ATPase activity (Ide) nucleus (Ide)
Anatomy Link Frequency
pancreatic islets 2
beta cells 2
gut 2
Ide (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 11 99.66 Very High Very High Very High
agonist 55 98.16 Very High Very High Very High
Clonidine 3 92.20 High High
monoamine 13 88.48 High High
tolerance 43 85.52 High High
Serotonin 2 83.16 Quite High
Central nervous system 5 74.48 Quite High
Neuropeptide 2 74.48 Quite High
Dopamine 1 59.52 Quite High
adenocard 5 57.20 Quite High
Disease Link Frequency Relevance Heat
Metabolic Disorder 2 99.58 Very High Very High Very High
Diabetes Mellitus-type I 1 99.32 Very High Very High Very High
Diabetes Mellitus 129 99.20 Very High Very High Very High
Insulin Resistance 29 99.04 Very High Very High Very High
Disease 29 98.94 Very High Very High Very High
Wound Healing 15 98.68 Very High Very High Very High
Hyperglycemia 39 96.12 Very High Very High Very High
Necrosis 2 94.12 High High
Targeted Disruption 65 90.76 High High
Injury 3 87.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adrenaline, however, markedly suppressed the insulin release induced by a maximal dose of glucose.
Negative_regulation (suppressed) of Localization (release) of insulin
1) Confidence 0.44 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8096820 Disease Relevance 0 Pain Relevance 0.91
In conclusion, our data in the fed and post-prandial state in mice demonstrate a role of the P2Y1 receptor in the maintenance of glucose homeostasis, at least in part through negative regulation of insulin secretion.
Negative_regulation (regulation) of Localization (secretion) of insulin
2) Confidence 0.34 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.27 Pain Relevance 0.03
In mice, unlike in other species, the extracellular nucleotides ATP and ADP have been shown to inhibit insulin release from islet cells [31].
Negative_regulation (inhibit) of Localization (release) of insulin
3) Confidence 0.34 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0 Pain Relevance 0.07
All these data disagree with our observation that absence of the P2Y1 receptor contributes to increase insulin secretion instead of decreasing it.
Negative_regulation (decreasing) of Localization (secretion) of insulin
4) Confidence 0.25 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0 Pain Relevance 0.09
-cell function is improved in P2Y1-deficient mice, particularly in the presence of high glucose concentrations, pointing to a putative inhibitory effect of the P2Y1 receptor on insulin secretion.
Negative_regulation (effect) of Localization (secretion) of insulin
5) Confidence 0.25 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.13 Pain Relevance 0.07
Pancreas morphology and insulin content, and insulin secretion in isolated pancreatic islets
Negative_regulation (morphology) of Localization (secretion) of insulin in pancreatic islets
6) Confidence 0.25 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.36 Pain Relevance 0.07
They also display reduced first-phase glucose-stimulated insulin secretion, reduced insulin processing enzyme transcripts and increased proinsulin levels.
Negative_regulation (reduced) of Localization (secretion) of insulin
7) Confidence 0.17 Published 2010 Journal Diabetologia Section Body Doc Link 20424817 Disease Relevance 0 Pain Relevance 0
In type 1 diabetes (insulin-dependent diabetes mellitus (IDDM)), this results from an absolute deficiency of insulin secretion [10].
Negative_regulation (deficiency) of Localization (secretion) of insulin associated with diabetes mellitus-type i and diabetes mellitus
8) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775636 Disease Relevance 2.30 Pain Relevance 0.04
On the other hand, alloxan has two distinct pathological effects: it selectively inhibits glucose-induced insulin secretion through specific inhibition of glucokinase, the glucose sensor of the beta cell, and it causes a state of insulin-dependent diabetes by selective necrosis of beta cells in type 1 and type 2 diabetes mellitus [24-26].
Negative_regulation (inhibits) of Localization (secretion) of insulin in beta cells associated with necrosis and diabetes mellitus
9) Confidence 0.13 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2785813 Disease Relevance 0.88 Pain Relevance 0
The infusion into the brain of the GLP-1 receptor antagonist exendin-9 (Ex9) inhibited insulin secretion induced by gut glucose (11).
Negative_regulation (inhibited) of Localization (secretion) of insulin in gut associated with antagonist
10) Confidence 0.09 Published 2008 Journal Diabetes Section Body Doc Link PMC2551665 Disease Relevance 0.17 Pain Relevance 0.13
Diabetes mellitus a lifelong progressive disease is a chronic metabolic disorder due to the relative deficiency of insulin secretion and varying degrees of insulin resistance and is characterized by high circulating glucose [1].
Negative_regulation (deficiency) of Localization (secretion) of insulin associated with metabolic disorder, diabetes mellitus, insulin resistance and disease
11) Confidence 0.04 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2914719 Disease Relevance 0.79 Pain Relevance 0
NCoA6+/- mice exhibit decreased insulin secretion
Negative_regulation (decreased) of Localization (secretion) of insulin
12) Confidence 0.01 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.46 Pain Relevance 0

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