INT56498

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Context Info
Confidence 0.42
First Reported 1993
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.26
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Maoa) oxidoreductase activity (Maoa)
Maoa (Mus musculus)
Pain Link Frequency Relevance Heat
monoamine 15 100.00 Very High Very High Very High
Clonidine 3 99.84 Very High Very High Very High
Nicotine 11 98.64 Very High Very High Very High
Serotonin 2 98.16 Very High Very High Very High
agonist 5 93.92 High High
Eae 1 83.20 Quite High
Nucleus accumbens 1 80.68 Quite High
Dopamine 2 79.68 Quite High
opiate 1 71.00 Quite High
Disease Link Frequency Relevance Heat
Nicotine Addiction 3 87.92 High High
Targeted Disruption 1 86.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among 15 individual or combined MAOIs, including harmane, norharmane, moclobemide, selegiline, pargyline, clorgyline, tranylcypromine and phenelzine, only irreversible inhibitors of both MAO-A and -B (tranylcypromine, phenelzine, and clorgyline+selegiline) allowed a locomotor response to nicotine.
Negative_regulation (inhibitors) of Localization (clorgyline+selegiline) of MAO associated with nicotine
1) Confidence 0.42 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16395299 Disease Relevance 0.26 Pain Relevance 0.70
These effects on insulin secretion and monoamine oxidase activity could not be blocked by clonidine.
Negative_regulation (blocked) of Localization (secretion) of monoamine oxidase associated with clonidine and monoamine
2) Confidence 0.39 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8096820 Disease Relevance 0 Pain Relevance 1.07

General Comments

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