INT56524

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Context Info
Confidence 0.74
First Reported 1993
Last Reported 2010
Negated 3
Speculated 3
Reported most in Abstract
Documents 67
Total Number 72
Disease Relevance 14.77
Pain Relevance 26.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Grip2) plasma membrane (Grip2) cytoskeleton (Grip2)
cytoplasm (Grip2)
Anatomy Link Frequency
neurons 9
spinal cord 4
brain 3
hippocampus 3
dorsal horn 3
Grip2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 928 100.00 Very High Very High Very High
nMDA receptor 614 100.00 Very High Very High Very High
antagonist 454 100.00 Very High Very High Very High
Glutamate receptor 441 100.00 Very High Very High Very High
agonist 38 100.00 Very High Very High Very High
Dorsal horn neuron 36 100.00 Very High Very High Very High
Root ganglion neuron 4 99.98 Very High Very High Very High
anesthesia 14 99.84 Very High Very High Very High
dorsal root ganglion 30 99.82 Very High Very High Very High
qutenza 14 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aging 115 100.00 Very High Very High Very High
Diabetes Mellitus 174 99.92 Very High Very High Very High
Ganglion Cysts 44 99.82 Very High Very High Very High
Infarction 2 99.48 Very High Very High Very High
Hyperalgesia 69 98.92 Very High Very High Very High
INFLAMMATION 44 98.92 Very High Very High Very High
Neuropathic Pain 36 98.76 Very High Very High Very High
Pain 31 98.48 Very High Very High Very High
Nociception 115 98.20 Very High Very High Very High
Nervous System Injury 99 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most DRG neurons in culture expressed kainate receptors and about half also expressed AMPA receptors.
Gene_expression (expressed) of AMPA in DRG associated with dorsal root ganglion
1) Confidence 0.74 Published 2004 Journal Neuroscience Section Abstract Doc Link 15489026 Disease Relevance 0.54 Pain Relevance 0.64
Selective changes in the expression of the flip-flop splice variants of the AMPA receptor suggest a reorganization of the composition of the AMPA receptor complex and its involvement in the development of inflammatory hyperalgesia.
Gene_expression (expression) of AMPA receptor associated with hyperalgesia and inflammation
2) Confidence 0.69 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11295247 Disease Relevance 0.80 Pain Relevance 0.64
The increase in AMPA receptor expression peaks 14 days after nerve ligation and decreases 35 days post-ligation, corresponding to the time-course of heightened sensitivity to mechanical and thermal noxious stimuli (hyperalgesia) induced by the ligation.
Gene_expression (expression) of AMPA in nerve associated with hyperalgesia
3) Confidence 0.67 Published 1996 Journal Neuroscience Section Abstract Doc Link 8843072 Disease Relevance 0.50 Pain Relevance 0.81
Dorsal root ganglion neurons express functional AMPA and kainate receptors near their central terminals.
Gene_expression (express) of AMPA in neurons associated with ganglion cysts and root ganglion neuron
4) Confidence 0.64 Published 2004 Journal Neuroscience Section Abstract Doc Link 15489026 Disease Relevance 0.29 Pain Relevance 0.28
Functional similarities and differences of AMPA and kainate receptors expressed by cultured rat sensory neurons.
Gene_expression (expressed) of AMPA in sensory neurons associated with qutenza
5) Confidence 0.64 Published 2004 Journal Neuroscience Section Title Doc Link 15489026 Disease Relevance 0.47 Pain Relevance 0.66
By method of Western blot, expression of GluR1 (the main subunit of the AMPA receptor) and its phosphorylated forms at serine 845 (pGluR1-Ser845) and at serine 831 (pGluR1-Ser831) in the spinal dorsal horn was observed.
Gene_expression (expression) of AMPA receptor in dorsal horn associated with spinal dorsal horn
6) Confidence 0.60 Published 2008 Journal Brain Res. Section Abstract Doc Link 18289517 Disease Relevance 0.76 Pain Relevance 0.86
These results demonstrate an increased expression of AMPA receptor subunits that correlates with the acute phase of CFA-induced inflammation and hyperalgesia.
Gene_expression (expression) of AMPA receptor associated with hyperalgesia and inflammation
7) Confidence 0.60 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11295247 Disease Relevance 0.69 Pain Relevance 0.66
The observed rectification of synaptic responses suggests that synaptic AMPA receptors in layer I neurons may lack GluR-2 subunits and may be Ca2+ permeable.
Neg (lack) Gene_expression (lack) of AMPA in neurons
8) Confidence 0.57 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9163367 Disease Relevance 0 Pain Relevance 0.08
Glutamate elicited more action potentials and a larger steady-state depolarization in neurons expressing both AMPA and kainate receptors than in neurons expressing only kainate receptors.
Gene_expression (expressing) of AMPA in neurons associated with action potential and glutamate
9) Confidence 0.50 Published 2004 Journal Neuroscience Section Abstract Doc Link 15489026 Disease Relevance 0.57 Pain Relevance 0.83
In the present study, we used reverse transcription-polymerase chain reaction (RT-PCR) to examine the modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor gene expression in the rat spinal cord by inflammation.
Gene_expression (expression) of AMPA in spinal cord associated with inflammation and spinal cord
10) Confidence 0.47 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11295247 Disease Relevance 0.82 Pain Relevance 0.58
Late embryonic expression of AMPA receptor function in the CA1 region of the intact hippocampus in vitro.
Gene_expression (expression) of AMPA receptor in hippocampus associated with hippocampus
11) Confidence 0.45 Published 1999 Journal Eur. J. Neurosci. Section Title Doc Link 10583490 Disease Relevance 0 Pain Relevance 0.29
Immunocytochemical and Co(2+) uptake studies revealed that in primary cultures of rat cortical neurones, the majority of neurones are gamma-aminobutyric acid (GABA) immunopositive and can express Ca(2+)-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors.
Gene_expression (express) of AMPA associated with gaba
12) Confidence 0.41 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11906710 Disease Relevance 0 Pain Relevance 0.13
Louis, MO, U.S.A.), MK801 (NMDA receptor antagonist; Research Biochemical Internationals [RBI], Natick, U.S.A.) and NBQX (AMPA receptor antagonist; Tocris Cookson Ltd., Bristol, U.K.).
Gene_expression (antagonist) of AMPA receptor associated with nmda receptor antagonist and antagonist
13) Confidence 0.32 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808611 Disease Relevance 0.45 Pain Relevance 0.86
AMPA receptor subunits GluR1, -R2, -R3 and -R4 mRNAs were expressed in a large number of gracile nucleus neurons.
Gene_expression (expressed) of AMPA in neurons
14) Confidence 0.31 Published 2002 Journal Pain Section Abstract Doc Link 11790478 Disease Relevance 0.54 Pain Relevance 0.69
Concurrent delivery of gabapentin with either NMDA antagonist or AMPA antagonist may well have virtue in dealing with pain, as it serves to reduce the required dose of each drug



Gene_expression (antagonist) of AMPA associated with pain, antagonist and gabapentin
15) Confidence 0.28 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808611 Disease Relevance 0.71 Pain Relevance 1.33
Interestingly, in this study, spinal NMDA antagonist and AMPA antagonist reduced not only the phase 1 response but also the phase 2 response.
Gene_expression (antagonist) of AMPA in spinal associated with antagonist
16) Confidence 0.28 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808611 Disease Relevance 0.81 Pain Relevance 1.09
Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are expressed by inhibitory interneurons and have been shown to modulate GABA release in other regions of the CNS.
Gene_expression (expressed) of AMPA in inhibitory interneurons associated with gaba
17) Confidence 0.23 Published 2006 Journal Neuroscience Section Abstract Doc Link 16472927 Disease Relevance 0.10 Pain Relevance 0.56
Increased AMPA receptor surface expression after activity blockade required protein synthesis and was occluded by inhibition of the ubiquitin-proteasome system.
Gene_expression (expression) of AMPA
18) Confidence 0.23 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19674091 Disease Relevance 0.05 Pain Relevance 0.69
Ionotropic glutamate receptors (IGR), including NMDA, AMPA, and kainate receptors, are expressed in terminals with varied morphology in the superficial laminae (I-III) of the dorsal horn of the spinal cord.
Gene_expression (expressed) of AMPA in spinal cord associated with glutamate receptor, dorsal horn and spinal cord
19) Confidence 0.22 Published 2005 Journal J. Comp. Neurol. Section Abstract Doc Link 15844209 Disease Relevance 0 Pain Relevance 0.44
In order to further elucidate this hypothesis, the aim of the present study was to determine whether these enkephalinoceptive neurons express GluR1 and GluR2/3 AMPA receptor subunits.
Spec (whether) Gene_expression (express) of AMPA in neurons
20) Confidence 0.20 Published 1997 Journal Synapse Section Abstract Doc Link 9068124 Disease Relevance 0 Pain Relevance 0.25

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