INT56525

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Context Info
Confidence 0.75
First Reported 1993
Last Reported 2010
Negated 3
Speculated 3
Reported most in Body
Documents 74
Total Number 83
Disease Relevance 23.15
Pain Relevance 28.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Gria2) plasma membrane (Gria2) protein complex (Gria2)
Anatomy Link Frequency
dorsal horn 10
neurons 6
amygdala 3
retina 2
hippocampus 2
Gria2 (Rattus norvegicus)
Gria2 - L504Y (2)
Pain Link Frequency Relevance Heat
Glutamate 739 100.00 Very High Very High Very High
depression 738 100.00 Very High Very High Very High
Glutamate receptor 566 100.00 Very High Very High Very High
Cannabinoid 382 100.00 Very High Very High Very High
Ventral tegmentum 714 99.98 Very High Very High Very High
Inflammation 386 99.84 Very High Very High Very High
Spinal cord 305 99.84 Very High Very High Very High
Dorsal horn 292 99.84 Very High Very High Very High
qutenza 41 99.78 Very High Very High Very High
Hippocampus 373 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 738 100.00 Very High Very High Very High
INFLAMMATION 392 99.84 Very High Very High Very High
Cv Unclassified Under Development 102 99.54 Very High Very High Very High
Diabetes Mellitus 436 99.44 Very High Very High Very High
Epilepsy 16 99.32 Very High Very High Very High
Li-fraumeni Syndrome 112 99.02 Very High Very High Very High
Herpes Simplex Virus 1 98.98 Very High Very High Very High
Nociception 136 98.84 Very High Very High Very High
Recurrence 29 98.84 Very High Very High Very High
Death 53 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Crystal Structure of the Near-Intact AMPA-R made of GluR2cryst Homotetramer
Gene_expression (made) of GluR2
1) Confidence 0.75 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0.05
First, gel filtration was used to identify GluA2flip as the subunit that expresses and folds the best in Sf9 cells.
Gene_expression (expresses) of GluA2
2) Confidence 0.65 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0.04
The observed rectification of synaptic responses suggests that synaptic AMPA receptors in layer I neurons may lack GluR-2 subunits and may be Ca2+ permeable.
Neg (lack) Gene_expression (lack) of GluR-2 in neurons
3) Confidence 0.65 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9163367 Disease Relevance 0 Pain Relevance 0.08
Widespread expression of the AMPA receptor GluR2 subunit at glutamatergic synapses in the rat spinal cord and phosphorylation of GluR1 in response to noxious stimulation revealed with an antigen-unmasking method.
Gene_expression (expression) of GluR2 in spinal cord associated with qutenza and spinal cord
4) Confidence 0.65 Published 2004 Journal J. Neurosci. Section Title Doc Link 15215299 Disease Relevance 0 Pain Relevance 0.39
Colocalization studies showed that GluR2 was present at virtually all (98%) puncta that were GluR1, GluR3, or GluR4 immunoreactive and that most (>90%) immunoreactive puncta in laminas IV, V, and IX showed GluR2, GluR3, and GluR4 immunoreactivity.
Gene_expression (present) of GluR2 in laminas
5) Confidence 0.65 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15215299 Disease Relevance 0 Pain Relevance 0.34
TTX blockade, on the other hand, induced a significant down-regulation of GluR2 immunoreactivity, GluR2 gene expression as well as CO activity (P < 0.01 for all).
Gene_expression (expression) of GluR2 associated with tetrodotoxin
6) Confidence 0.64 Published 2003 Journal J. Neurocytol. Section Abstract Doc Link 14618102 Disease Relevance 0 Pain Relevance 0.31
Differential expression of GluR1 and GluR2 subunits suggests regulation of AMPA receptor subunit composition by presynaptic mechanism.
Gene_expression (expression) of GluR2
7) Confidence 0.64 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18815255 Disease Relevance 0 Pain Relevance 0.19
Motor neurons very strongly express GluR3 and 4, while the expression of GluR2 and GluR1 is moderate and low, respectively.
Gene_expression (expression) of GluR2 in Motor neurons
8) Confidence 0.62 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8097549 Disease Relevance 0.16 Pain Relevance 0.48
Expression of GluR1 and GluR2 proteins in the total soluble fraction, crude membrane fraction, and crude cytosolic fraction was examined.
Spec (examined) Gene_expression (Expression) of GluR2
9) Confidence 0.62 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.09 Pain Relevance 0.10
An unexpected observation in the current study was that CFA injection did not produce a marked change in the levels of GluR1 and GluR2 in subcellular fractions from dorsal horn at 2 h post-CFA injection.
Gene_expression (levels) of GluR2 in dorsal horn associated with dorsal horn
10) Confidence 0.62 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.25 Pain Relevance 0.40
Effect of CFA-induced peripheral inflammation on the levels of GluR1 and GluR2 proteins in plasma membrane fraction and cytosolic fraction from dorsal horn
Gene_expression (levels) of GluR2 in dorsal horn associated with inflammation and dorsal horn
11) Confidence 0.62 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.25 Pain Relevance 0.39
In addition, we show that CFA-induced peripheral inflammation leads to GluR2 internalization and GluR1 membrane insertion in dorsal horn neurons, without altering the expression and distribution of total GluR1 and GluR2 proteins in dorsal horn.
Gene_expression (expression) of GluR2 in dorsal horn associated with inflammation, dorsal horn and dorsal horn neuron
12) Confidence 0.62 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 1.02 Pain Relevance 0.92
We then examined whether CFA-induced peripheral inflammation altered expression and distribution of total GluR1 and GluR2 proteins in dorsal horn.
Gene_expression (expression) of GluR2 in dorsal horn associated with inflammation and dorsal horn
13) Confidence 0.62 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.60 Pain Relevance 0.69
Quantitative Western blot analyses from the present study and those of others [29,30] further demonstrated that the expression levels of total GluR1 and GluR2 proteins were not significantly changed in dorsal horn under CFA-induced inflammatory pain conditions.
Gene_expression (expression) of GluR2 in dorsal horn associated with eae and dorsal horn
14) Confidence 0.62 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.59 Pain Relevance 0.57
In order to further elucidate this hypothesis, the aim of the present study was to determine whether these enkephalinoceptive neurons express GluR1 and GluR2/3 AMPA receptor subunits.
Spec (whether) Gene_expression (express) of GluR2 in neurons
15) Confidence 0.58 Published 1997 Journal Synapse Section Abstract Doc Link 9068124 Disease Relevance 0 Pain Relevance 0.25
GluR1 and GluR2 surface expression was also increased by tetrodotoxin alone or in combination with an N-methyl-d-aspartate receptor or AMPA receptor antagonist but not by the l-type Ca(2+) channel antagonist nifedipine.
Gene_expression (expression) of GluR2 associated with tetrodotoxin and antagonist
16) Confidence 0.55 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19674091 Disease Relevance 0.07 Pain Relevance 0.64
These findings show a close relationship between the glutamergic nociceptive primary afferent system and AMPA-type receptors in which GluR2 is especially highly expressed.
Gene_expression (expressed) of GluR2 associated with nociception
17) Confidence 0.54 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8097549 Disease Relevance 0.17 Pain Relevance 0.52
In addition, repeated morphine treatment followed by 7 days (but not 24 h) washout decreased GluR2 mRNA expression in both the amygdala (by 50%) and hippocampus (by 35%).
Gene_expression (expression) of GluR2 in amygdala associated with hippocampus, amygdala and morphine
18) Confidence 0.54 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18671727 Disease Relevance 0 Pain Relevance 0.86
One important observation that we made is that peripheral persistent inflammation produces distinct changes in the levels of GluR1 and GluR2 in plasma membrane and cytosolic fractions from dorsal horn.
Gene_expression (levels) of GluR2 in dorsal horn associated with inflammation and dorsal horn
19) Confidence 0.54 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.35 Pain Relevance 0.54
Neither the GluR1 nor the GluR2 levels were significantly changed in either the cytosolic (Fig. 4A, C; p > 0.05) or membrane (Fig. 4B, D; p > 0.05) fraction at 2 h post-CFA injection (n = 4).
Gene_expression (levels) of GluR2
20) Confidence 0.54 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.14 Pain Relevance 0.17

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