INT56526

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Context Info
Confidence 0.75
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.15
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gria4)
Anatomy Link Frequency
Scattered neurons 1
laminas 1
anterior pituitary 1
Gria4 (Rattus norvegicus)
Gria4 - L504Y (1)
Pain Link Frequency Relevance Heat
Glutamate receptor 24 100.00 Very High Very High Very High
antagonist 48 99.34 Very High Very High Very High
Glutamate 48 97.66 Very High Very High Very High
Dorsal horn neuron 1 97.44 Very High Very High Very High
Dorsal horn 7 95.52 Very High Very High Very High
Neurotransmitter 9 91.16 High High
nMDA receptor 6 89.44 High High
Spinal cord 4 75.00 Quite High
unmyelinated 1 69.52 Quite High
Peripheral nervous system 1 68.48 Quite High
Disease Link Frequency Relevance Heat
Nociception 2 77.52 Quite High
Adenoma 5 39.24 Quite Low
Attention Deficit Hyperactivity Disorder 1 15.44 Low Low
Sprains And Strains 1 10.76 Low Low
Stress 50 5.00 Very Low Very Low Very Low
INFLAMMATION 28 5.00 Very Low Very Low Very Low
Targeted Disruption 22 5.00 Very Low Very Low Very Low
Cancer 22 5.00 Very Low Very Low Very Low
Pituitary Cancer 11 5.00 Very Low Very Low Very Low
Starvation 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Scattered neurons moderately expressing GluR3 were also seen in these regions, while the expression of GluR4 was very low.
Gene_expression (expression) of GluR4 in Scattered neurons
1) Confidence 0.75 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8097549 Disease Relevance 0.15 Pain Relevance 0.51
Colocalization studies showed that GluR2 was present at virtually all (98%) puncta that were GluR1, GluR3, or GluR4 immunoreactive and that most (>90%) immunoreactive puncta in laminas IV, V, and IX showed GluR2, GluR3, and GluR4 immunoreactivity.
Gene_expression (immunoreactive) of GluR4 in laminas
2) Confidence 0.47 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15215299 Disease Relevance 0 Pain Relevance 0.34
Glutamate or certain aspartate analogues have been found to stimulate PRL, GH and LH release and rat anterior pituitary cells express mRNA of glutamate receptors GluR1, GluR2, GluR3, GluR4, GluR5, GluR6, GluR7, KA1 and KA2 subunits (765).
Gene_expression (express) of GluR4 in anterior pituitary associated with glutamate and glutamate receptor
3) Confidence 0.08 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.61
Furthermore, continuous application of competitive antagonist NBQX in culture rescued surface expression of the analogous L504Y mutation in GluA4 subunit [167].
Gene_expression (expression) of GluA4 subunit (L504Y) associated with antagonist
4) Confidence 0.01 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0.08

General Comments

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