INT56527

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Context Info
Confidence 0.62
First Reported 1993
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.27
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grik1) plasma membrane (Grik1)
Anatomy Link Frequency
motor neurons 1
dorsal horn 1
anterior pituitary 1
Grik1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 33 100.00 Very High Very High Very High
dorsal root ganglion 1 99.32 Very High Very High Very High
Glutamate 33 97.66 Very High Very High Very High
nMDA receptor 24 94.28 High High
Dorsal horn 9 93.12 High High
Neurotransmitter 9 91.16 High High
Spinal cord 4 75.00 Quite High
Dorsal horn neuron 2 74.60 Quite High
Peripheral nervous system 1 68.48 Quite High
gABA 15 67.44 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 7 99.32 Very High Very High Very High
Diabetes Mellitus 88 97.08 Very High Very High Very High
Nociception 4 84.24 Quite High
Adenoma 5 39.24 Quite Low
Attention Deficit Hyperactivity Disorder 1 15.44 Low Low
Sprains And Strains 1 10.76 Low Low
Stress 49 5.00 Very Low Very Low Very Low
INFLAMMATION 28 5.00 Very Low Very Low Very Low
Targeted Disruption 23 5.00 Very Low Very Low Very Low
Cancer 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Small neurones expressed GluR1-, GluR2/3-like immunoreactivities and GluR5, NR1, NRgbs mRNAs, while large neurones expressed GluR2/3-like immunoreactivity and NR1 and NRgbs mRNAs.
Spec (like) Gene_expression (expressed) of GluR5
1) Confidence 0.62 Published 1993 Journal Neuroreport Section Abstract Doc Link 8219025 Disease Relevance 0.10 Pain Relevance 0.27
The present study attempted to explore the gene expression of the subunits (GluR1-4) of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type receptor, subunit (GluR5) of kainic acid (KA)-type receptor, NR1 [a subunit of N-methyl-D-aspartate (NMDA) receptors] and the possible glutamate-binding subunit of an NMDA receptor complex in the dorsal horn of the rat spinal cords using in situ hybridization histochemistry.
Gene_expression (expression) of GluR5 in dorsal horn associated with glutamate, nmda receptor and dorsal horn
2) Confidence 0.47 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8097549 Disease Relevance 0.07 Pain Relevance 0.28
Expression of GluR5 is also low in the motor neurons.
Gene_expression (Expression) of GluR5 in motor neurons
3) Confidence 0.47 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8097549 Disease Relevance 0.16 Pain Relevance 0.48
The transcript levels of GluR5 and GluR6 subunits were below the detection level (data not shown).


Gene_expression (levels) of GluR5
4) Confidence 0.34 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 0.94 Pain Relevance 0.08
Glutamate or certain aspartate analogues have been found to stimulate PRL, GH and LH release and rat anterior pituitary cells express mRNA of glutamate receptors GluR1, GluR2, GluR3, GluR4, GluR5, GluR6, GluR7, KA1 and KA2 subunits (765).
Gene_expression (express) of GluR5 in anterior pituitary associated with glutamate and glutamate receptor
5) Confidence 0.07 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.61

General Comments

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