INT56528

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Context Info
Confidence 0.62
First Reported 1993
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 2.78
Pain Relevance 4.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gria3) protein complex (Gria3)
Anatomy Link Frequency
retina 1
spinal cord 1
brain 1
Scattered neurons 1
nucleus 1
Gria3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 89 100.00 Very High Very High Very High
Glutamate receptor 47 100.00 Very High Very High Very High
nMDA receptor 48 99.92 Very High Very High Very High
Spinal cord 18 98.96 Very High Very High Very High
ischemia 3 98.82 Very High Very High Very High
Dorsal horn 14 98.20 Very High Very High Very High
Hippocampus 18 97.36 Very High Very High Very High
substantia gelatinosa 4 96.32 Very High Very High Very High
addiction 4 94.92 High High
Dorsal horn neuron 2 92.40 High High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 2 98.82 Very High Very High Very High
Death 6 98.12 Very High Very High Very High
Drug Dependence 8 94.92 High High
Schizophrenia 10 94.16 High High
Middle Cerebral Artery Infarction 2 92.96 High High
Pressure And Volume Under Development 3 92.72 High High
Nociception 6 88.08 High High
Diabetes Mellitus 88 82.56 Quite High
Nervous System Injury 12 80.60 Quite High
INFLAMMATION 30 78.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GluR3 and NR1 were expressed at low levels throughout spinal cord gray matter.
Gene_expression (expressed) of GluR3 in spinal cord associated with spinal cord
1) Confidence 0.62 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 8126556 Disease Relevance 0.51 Pain Relevance 0.64
Scattered neurons moderately expressing GluR3 were also seen in these regions, while the expression of GluR4 was very low.
Gene_expression (expressing) of GluR3 in Scattered neurons
2) Confidence 0.58 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8097549 Disease Relevance 0.15 Pain Relevance 0.51
In contrast, no significant change was apparent in GluR2, GluR3, or NR1 expression in any nucleus of the cord.
Gene_expression (expression) of GluR3 in nucleus
3) Confidence 0.54 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 8126556 Disease Relevance 0.35 Pain Relevance 0.53
To characterize molecular events that precede cell death following transient focal ischemia, in situ hybridization histochemistry was used to measure levels of glutamate receptor subunit 1 (GluR1), GluR2, GluR3, N-methyl-D-aspartate receptor subunit 1 (NR1) and preproenkephalin messenger RNAs in adult rats at various recirculation times (1.5, 3 and 24 h) following a 90-min period of middle cerebral artery occlusion.
Gene_expression (levels) of GluR3 in middle cerebral artery associated with middle cerebral artery infarction, nmda receptor, glutamate receptor, ischemia and death
4) Confidence 0.51 Published 2000 Journal Neuroscience Section Abstract Doc Link 10670452 Disease Relevance 0.55 Pain Relevance 0.27
Motor neurons very strongly express GluR3 and 4, while the expression of GluR2 and GluR1 is moderate and low, respectively.
Gene_expression (express) of GluR3 in Motor neurons
5) Confidence 0.51 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8097549 Disease Relevance 0.16 Pain Relevance 0.48
Colocalization studies showed that GluR2 was present at virtually all (98%) puncta that were GluR1, GluR3, or GluR4 immunoreactive and that most (>90%) immunoreactive puncta in laminas IV, V, and IX showed GluR2, GluR3, and GluR4 immunoreactivity.
Gene_expression (immunoreactive) of GluR3 in laminas
6) Confidence 0.42 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15215299 Disease Relevance 0 Pain Relevance 0.34
Compared to the transcript levels in the retina of age-matched control rats, there were no significant changes in GluR1 (Figure 2A), GluR2 (Figure 2B), GluR3 (Figure 2C), and GluR4 (Figure 2D) subunits expression, except for GluR4 at the four weeks time point, which decreased to 68±9% of the control.
Gene_expression (expression) of GluR3 in retina
7) Confidence 0.32 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 0.69 Pain Relevance 0
In the hypothalamus, there was a significant increase of GluR1, GluR3, mGluR1, and mGluR3 gene-transcript expressions.


Gene_expression (expressions) of GluR3 in hypothalamus
8) Confidence 0.31 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2358913 Disease Relevance 0.11 Pain Relevance 0.30
The aim of the present study was to investigate the effect of repeated intermittent MDMA administration upon gene-transcript expression of the glutamate transporters (EAAT1, EAAT2-1, EAAT2-2), the glutamate receptor subunits of AMPA (GluR1, GluR2, GluR3), the glutamate receptor subunits of NMDA (NR1, NR2A and NR2B), as well as metabotropic glutamate receptors (mGluR1, mGluR2, mGluR3, mGluR5) in six different brain regions.
Spec (investigate) Gene_expression (expression) of GluR3 in brain associated with glutamate and glutamate receptor
9) Confidence 0.31 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2358913 Disease Relevance 0.19 Pain Relevance 0.46
While our methods do not permit us to distinguish between GluR2 and GluR3 subunits, examination of the Muñoz et al. (1999; Figure 1A) data from macaque monkeys finds the summed mRNA expression levels of GluR2 and GluR3 to be considerably higher than that of GluR1.
Gene_expression (expression) of GluR3
10) Confidence 0.24 Published 2008 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2638550 Disease Relevance 0.08 Pain Relevance 0
Glutamate or certain aspartate analogues have been found to stimulate PRL, GH and LH release and rat anterior pituitary cells express mRNA of glutamate receptors GluR1, GluR2, GluR3, GluR4, GluR5, GluR6, GluR7, KA1 and KA2 subunits (765).
Gene_expression (express) of GluR3 in anterior pituitary associated with glutamate and glutamate receptor
11) Confidence 0.09 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.61

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