INT5653

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1983
Last Reported 2010
Negated 4
Speculated 1
Reported most in Abstract
Documents 136
Total Number 137
Disease Relevance 72.78
Pain Relevance 27.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ELANE) extracellular region (ELANE) cytoplasm (ELANE)
Anatomy Link Frequency
neutrophil 23
leukocyte 7
plasma 6
granulocyte 6
blood 4
ELANE (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1273 100.00 Very High Very High Very High
cytokine 417 100.00 Very High Very High Very High
Dopamine 381 100.00 Very High Very High Very High
rheumatoid arthritis 356 100.00 Very High Very High Very High
chemokine 331 100.00 Very High Very High Very High
Spinal cord 6 100.00 Very High Very High Very High
anesthesia 87 99.88 Very High Very High Very High
Prostatitis 218 99.80 Very High Very High Very High
Chronic pancreatitis 9 99.76 Very High Very High Very High
Pain 72 99.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1368 100.00 Very High Very High Very High
Rheumatoid Arthritis 364 100.00 Very High Very High Very High
Apoptosis 331 100.00 Very High Very High Very High
Epilepsy 13 99.96 Very High Very High Very High
Emphysema 72 99.90 Very High Very High Very High
Colitis 25 99.88 Very High Very High Very High
Reprotox - General 1 10 99.80 Very High Very High Very High
Pancreatitis 37 99.76 Very High Very High Very High
Disease 414 99.72 Very High Very High Very High
Infection 474 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma elastase levels increased significantly at the end of the procedure compared with pre-PTCA values both in the coronary sinus (from 129.2 +/- 16.6 to 286.6 +/- 39.7 micrograms/l, p less than 0.005) and in the aorta (from 117.4 +/- 13.6 to 258.1 +/- 41.3 micrograms/l, p less than 0.005).
Positive_regulation (increased) of Plasma elastase in Plasma associated with percutaneous transluminal coronary angioplasty
1) Confidence 0.70 Published 1990 Journal Circulation Section Abstract Doc Link 2163778 Disease Relevance 0.18 Pain Relevance 0.41
We showed that a significant increase in markers characteristic of oxidative damage in the nigro-striatal pathway, such as 4-HNE, mitochondrial 8-oxoG, and DHE, occurred 24 h after MPTP administration. 4-HNE and 8-oxoG are well-known markers for oxidative insult mainly caused by ┬ĽOH. 4-HNE was observed in membrane surface of TH-positive dopaminergic neuron in SN, and mitochondrial 8-oxoG was accumulated in the striatum over the same period (24 h after MPTP administration).
Positive_regulation (increase) of HNE in dopaminergic neuron associated with parkinson's disease and substantia nigra
2) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.60 Pain Relevance 0.12
Furthermore, the peak of PMN-elastase increase throughout the course of the pancreatitis was seen to be 1-2 days after peak increase in pancreatic enzymes.
Positive_regulation (increase) of PMN-elastase in PMN associated with pancreatitis
3) Confidence 0.66 Published 1992 Journal Agents Actions Suppl. Section Abstract Doc Link 1462874 Disease Relevance 0.45 Pain Relevance 0.09
Especially, there was a particularly notable increase in amount of PMN-elastase in patients with severe pancreatitis.
Positive_regulation (increase) of PMN-elastase in PMN associated with pancreatitis
4) Confidence 0.66 Published 1992 Journal Agents Actions Suppl. Section Abstract Doc Link 1462874 Disease Relevance 0.45 Pain Relevance 0.09
There was a significantly larger increase in PMN-elastase in patients with pancreatitis than normal adults.
Positive_regulation (increase) of PMN-elastase in PMN associated with pancreatitis
5) Confidence 0.66 Published 1992 Journal Agents Actions Suppl. Section Abstract Doc Link 1462874 Disease Relevance 0.44 Pain Relevance 0.10
In assessing the elevated NE epilepsy hypothesis, the following seven lines of evidence are examined that include studies of: (1) antidepressants that raise the level of NE; (2) clonidine and other alpha 2 adrenergic agonist drugs that lower the level of NE; (3) prazosin and other drugs that affect alpha adrenoceptors; (4) propranolol and other drugs that affect beta adrenoceptors; (5) pheochromocytoma, which is a rare cancer of the adrenal glands that can boost NE levels; (6) comorbidity of epilepsy with bipolar disorder, hypertension, and obesity, where all four conditions may involve elevated NE; and (7) psychological stress, which is associated with increased release of NE.
Spec (may) Positive_regulation (elevated) of NE in adrenal glands associated with stress, adrenal cancer, pheochromocytoma, clonidine, epilepsy, antidepressant, manic depressive disorder, obesity, agonist and hypertension
6) Confidence 0.61 Published 2010 Journal Seizure Section Abstract Doc Link 20493725 Disease Relevance 0.92 Pain Relevance 0.28
In theory, SCN and CN are caused by an accumulation of neutrophil elastase, leading to an inactivation of G-CSF and a negative feedback on granulopoiesis, which causes neutropenia.
Positive_regulation (accumulation) of elastase in neutrophil associated with neutropenia and neutrophil disorders
7) Confidence 0.60 Published 2004 Journal BMC Blood Disord Section Body Doc Link PMC535939 Disease Relevance 0.91 Pain Relevance 0
causes accumulation of canine neutrophil elastase in the cytosolic compartments [12], and mutations in ELA2 may disrupt the AP3?
Positive_regulation (accumulation) of elastase in neutrophil
8) Confidence 0.60 Published 2004 Journal BMC Blood Disord Section Body Doc Link PMC535939 Disease Relevance 0.62 Pain Relevance 0
The elastase concentrations were increased in those with pancreatic tumours particularly when the head of the pancreas was involved.
Positive_regulation (increased) of elastase in pancreas associated with pancreatic cancer
9) Confidence 0.57 Published 1987 Journal Clin. Chim. Acta Section Abstract Doc Link 2440623 Disease Relevance 0.64 Pain Relevance 0.18
All of the men with chlamydial infection of the prostate gland had increased concentrations of PMN elastase and leukocyte counts and decreased concentrations of citric acid in EPS.
Positive_regulation (increased) of elastase in prostate gland associated with chlamydia infection
10) Confidence 0.56 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2778713 Disease Relevance 0.64 Pain Relevance 0.08
Two patients had higher PMN cell counts with no increase in elastase concentration.
Neg (no) Positive_regulation (increase) of elastase
11) Confidence 0.56 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2778713 Disease Relevance 0.54 Pain Relevance 0.12
In four cases, PMN elastase concentration was elevated, but with a lack of leukocytes.
Positive_regulation (elevated) of elastase in leukocytes
12) Confidence 0.56 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2778713 Disease Relevance 0.61 Pain Relevance 0.12
Increased neutrophil elastase release in unstable angina pectoris and acute myocardial infarction.
Positive_regulation (Increased) of neutrophil elastase in neutrophil associated with angina and myocardial infarction
13) Confidence 0.50 Published 1990 Journal J. Am. Coll. Cardiol. Section Title Doc Link 2345235 Disease Relevance 1.06 Pain Relevance 0.58
The supernatants were transferred to new tubes and assayed for elastase activity using Suc-Ala-Ala-Ala-pNA (Sigma) as a substrate.
Positive_regulation (assayed) of elastase in tubes
14) Confidence 0.50 Published 2004 Journal BMC Blood Disord Section Body Doc Link PMC535939 Disease Relevance 0 Pain Relevance 0
Serum human pancreatic elastase I levels in pancreatic disease.
Positive_regulation (pancreatic) of elastase associated with pancreatitis
15) Confidence 0.47 Published 1987 Journal Clin. Chim. Acta Section Title Doc Link 2440623 Disease Relevance 0.63 Pain Relevance 0.17
Clinical value of PMN elastase activity before reperfusion which is released from activated polymorphonuclear leucocyte were evaluated in 30 patients with acute myocardial infarction. 19 patients with normal or moderately elevated PMN elastase activity (G1: less than 200 micrograms/l) revealed similar clinical characteristics before reperfusion therapy, compared to 11 patients with extremely high PMN elastase activity (Group 1: greater than or equal to 200 micrograms/l).
Positive_regulation (elevated) of PMN elastase in polymorphonuclear leucocyte associated with myocardial infarction
16) Confidence 0.46 Published 1992 Journal Kokyu To Junkan Section Abstract Doc Link 1439293 Disease Relevance 0.49 Pain Relevance 0.11
The inhibition or activation of PMN-elastase by the test substances was dependent on the type and concentration of buffer, the pH, the presence of a tenside and most notably, the presence of electrolytes.
Positive_regulation (activation) of PMN-elastase
17) Confidence 0.45 Published 1990 Journal Arzneimittelforschung Section Abstract Doc Link 2334461 Disease Relevance 0 Pain Relevance 0.11
Human neutrophil elastase complexed to alpha 1-antitrypsin was increased in the patient's plasma, while the levels of the complexes thrombin-antithrombinIII and plasmin-alpha 2-antiplasmin, indicating recent coagulation or fibrinolysis, respectively, were not elevated.
Positive_regulation (increased) of elastase in neutrophil
18) Confidence 0.45 Published 1989 Journal Toxicology Section Abstract Doc Link 2469140 Disease Relevance 0.73 Pain Relevance 0.08
In assessing the elevated NE epilepsy hypothesis, the following seven lines of evidence are examined that include studies of: (1) antidepressants that raise the level of NE; (2) clonidine and other alpha 2 adrenergic agonist drugs that lower the level of NE; (3) prazosin and other drugs that affect alpha adrenoceptors; (4) propranolol and other drugs that affect beta adrenoceptors; (5) pheochromocytoma, which is a rare cancer of the adrenal glands that can boost NE levels; (6) comorbidity of epilepsy with bipolar disorder, hypertension, and obesity, where all four conditions may involve elevated NE; and (7) psychological stress, which is associated with increased release of NE.
Positive_regulation (elevated) of NE in adrenal glands associated with stress, adrenal cancer, pheochromocytoma, clonidine, epilepsy, antidepressant, manic depressive disorder, obesity, agonist and hypertension
19) Confidence 0.44 Published 2010 Journal Seizure Section Abstract Doc Link 20493725 Disease Relevance 0.83 Pain Relevance 0.32
We observed an increased concentration of granulocyte elastase in 36/46 (78.3%) patients.
Positive_regulation (increased) of granulocyte elastase in granulocyte
20) Confidence 0.43 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2778713 Disease Relevance 0.57 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox