INT56560

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Context Info
Confidence 0.70
First Reported 1993
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.37
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Hrh1) plasma membrane (Hrh1) nucleus (Hrh1)
cytoplasm (Hrh1) signal transducer activity (Hrh1)
Anatomy Link Frequency
sensory nerves 1
supraoptic nucleus 1
nociceptor 1
Hrh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nociceptor 2 97.88 Very High Very High Very High
Snapping jaw 11 93.48 High High
Inflammation 3 89.76 High High
Action potential 1 75.80 Quite High
qutenza 4 75.00 Quite High
antagonist 9 71.92 Quite High
tetrodotoxin 1 63.68 Quite High
lidocaine 1 60.88 Quite High
agonist 1 48.16 Quite Low
Pain 6 34.08 Quite Low
Disease Link Frequency Relevance Heat
Peptic Ulcer 6 99.08 Very High Very High Very High
Stress 8 98.64 Very High Very High Very High
Nociception 12 93.96 High High
Temporomandibular Joint Syndrome 11 93.48 High High
Ulcers 7 91.16 High High
INFLAMMATION 3 89.76 High High
Pain 2 34.08 Quite Low
Temporomandibular Joint Disorders 1 30.44 Quite Low
Injury 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is proposed that histamine activates the H1 receptor to induce the release of 5-HT which depolarizes the nociceptor by activating 5-HT(3) receptor.
Positive_regulation (activates) of H1 receptor in nociceptor associated with nociceptor
1) Confidence 0.70 Published 2007 Journal Life Sci. Section Abstract Doc Link 17706725 Disease Relevance 1.21 Pain Relevance 0.74
Histamine enhances the depolarizing afterpotential of immunohistochemically identified vasopressin neurons in the rat supraoptic nucleus via H1-receptor activation.
Positive_regulation (activation) of H1-receptor in supraoptic nucleus
2) Confidence 0.65 Published 1993 Journal Neuroscience Section Title Doc Link 8098142 Disease Relevance 0 Pain Relevance 0.10
We conclude that: (1) histamine exhibits protective effect against stress-induced gastric ulcer and that this gastroprotection is related to stimulation of histamine H1 and H3 receptors; (2) blockade of histamine H2 receptors exhibited beneficial effect on gastric mucosa against stress-induced gastric ulcers; and (3) ablation of sensory nerves aggravates stress-induced gastric ulcer and reduces histamine-evoked gastroprotection related to stimulation of histamine H3 receptors.
Positive_regulation (stimulation) of histamine H1 in sensory nerves associated with stress and peptic ulcer
3) Confidence 0.64 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15680274 Disease Relevance 1.16 Pain Relevance 0.10

General Comments

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