INT56562

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Context Info
Confidence 0.45
First Reported 1993
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 3.17
Pain Relevance 4.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
joint 2
T cells 2
Il2rb (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 24 98.56 Very High Very High Very High
rheumatoid arthritis 11 98.04 Very High Very High Very High
spinal inflammation 9 97.52 Very High Very High Very High
antagonist 2 96.80 Very High Very High Very High
opiate 8 96.36 Very High Very High Very High
Pain 5 96.02 Very High Very High Very High
Kinase C 8 95.32 Very High Very High Very High
cytokine 39 95.08 Very High Very High Very High
Inflammatory response 2 87.56 High High
Inflammation 14 79.24 Quite High
Disease Link Frequency Relevance Heat
Cancer 10 98.84 Very High Very High Very High
Necrosis 1 98.60 Very High Very High Very High
Rheumatoid Arthritis 11 98.04 Very High Very High Very High
Low Back Pain 9 97.52 Very High Very High Very High
Arthralgia 5 96.02 Very High Very High Very High
Lymphatic System Cancer 44 94.52 High High
INFLAMMATION 17 87.20 High High
Apoptosis 4 87.20 High High
Autoimmune Disease 8 82.24 Quite High
Disease 58 80.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibition of PMA-stimulated IL-2R expression was not reproduced by incubating splenocytes with morphine (10(-8)-10(-5) M).
Positive_regulation (stimulated) of Gene_expression (expression) of IL-2R associated with morphine
1) Confidence 0.45 Published 1993 Journal Life Sci. Section Abstract Doc Link 8098501 Disease Relevance 0 Pain Relevance 1.54
Administration of morphine significantly inhibited the phorbol myristate acetate (PMA)-stimulated increase in interleukin-2 receptor (IL-2R) expression in both CD4+ and CD8+ mouse T cells.
Positive_regulation (increase) of Gene_expression (expression) of IL-2R in T cells associated with morphine
2) Confidence 0.45 Published 1993 Journal Life Sci. Section Abstract Doc Link 8098501 Disease Relevance 0 Pain Relevance 1.09
This observation suggests that increases in expression of components of the IL-2R can be achieved by retinoids and rexinoids, and that may enhance the cytotoxicity of DD.
Positive_regulation (increases) of Gene_expression (expression) of IL-2R
3) Confidence 0.16 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727893 Disease Relevance 0.45 Pain Relevance 0
In these mice lacking Tyro-3 receptors, elevated expressions of IL-2R, CD69, Fas, and IFN?
Positive_regulation (elevated) of Gene_expression (expressions) of IL-2R
4) Confidence 0.01 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654796 Disease Relevance 0.47 Pain Relevance 0.15
The presence of two or three of the following three items in patients with joint pain without any bone and joint destruction was thus indicated to be useful for the early diagnosis of RA: elevated CRP level (> or = 1.0 mg/dl), positive rheumatoid factor (RF) (> or = 30 IU/ml) and an elevated sIL-2R level (> or = 100 pmol/l).
Positive_regulation (elevated) of Gene_expression (level) of sIL-2R in joint associated with pain, arthralgia and rheumatoid arthritis
5) Confidence 0.01 Published 1998 Journal Clin. Rheumatol. Section Abstract Doc Link 9776115 Disease Relevance 1.07 Pain Relevance 0.68
In this study, we demonstrated increased serum levels of soluble interleukin-2 receptor (sIL-2R), Interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in patients with AS compared with healthy subjects.
Positive_regulation (increased) of Gene_expression (levels) of sIL-2R associated with spinal inflammation, necrosis and cancer
6) Confidence 0.00 Published 2007 Journal Clin. Rheumatol. Section Abstract Doc Link 16583185 Disease Relevance 1.17 Pain Relevance 0.88

General Comments

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