INT56580

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Context Info
Confidence 0.67
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 2.95
Pain Relevance 7.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr1b) cytoplasm (Htr1b) signal transducer activity (Htr1b)
Anatomy Link Frequency
entopeduncular nucleus 1
smooth muscle 1
spinal cord 1
subthalamic nucleus 1
caudate-putamen 1
Htr1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 38 100.00 Very High Very High Very High
Periaqueductal grey 110 99.90 Very High Very High Very High
Hyperalgesia 15 99.60 Very High Very High Very High
Analgesic 16 99.32 Very High Very High Very High
antinociception 4 99.20 Very High Very High Very High
analgesia 8 98.78 Very High Very High Very High
agonist 50 98.68 Very High Very High Very High
Sumatriptan 111 98.38 Very High Very High Very High
GABAergic 54 98.36 Very High Very High Very High
sSRI 11 98.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 112 99.90 Very High Very High Very High
Increased Venous Pressure Under Development 2 99.82 Very High Very High Very High
Hyperalgesia 17 99.60 Very High Very High Very High
Nociception 20 98.56 Very High Very High Very High
Headache 21 98.04 Very High Very High Very High
Anxiety Disorder 5 97.04 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 5 97.00 Very High Very High Very High
Depression 3 94.20 High High
Pain 31 92.36 High High
Shock 1 86.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This mechanism might be attributable to vasoconstriction through activation of 5-HT1B receptors located in the vascular smooth muscle rather than 5-HT1B receptors in the vascular adventitia.
Positive_regulation (activation) of 5-HT1B in smooth muscle associated with increased venous pressure under development
1) Confidence 0.67 Published 2002 Journal Cephalalgia Section Abstract Doc Link 12133047 Disease Relevance 0.33 Pain Relevance 0.53
It is concluded that the release of 5-HT from the rat amygdalopiriform cortex in vivo is tightly restricted due to activation of 5-HT1B receptors.
Positive_regulation (activation) of 5-HT1B in cortex
2) Confidence 0.67 Published 1995 Journal Brain Res. Section Abstract Doc Link 8548293 Disease Relevance 0 Pain Relevance 0.22
These results demonstrate that, under the present experimental conditions, activation of central 5-HT1A, 5-HT1B, and 5-HT2 receptors reduced ethanol intake and reinforced behaviour in an operant paradigm.
Positive_regulation (activation) of 5-HT1B
3) Confidence 0.67 Published 1998 Journal Alcohol Section Abstract Doc Link 9744857 Disease Relevance 0.07 Pain Relevance 0.55
Selective increases in serotonin 5-HT1B/1D and 5-HT2A/2C binding sites in adult rat basal ganglia following lesions of serotonergic neurons.
Positive_regulation (increases) of 5-HT1B in basal ganglia associated with serotonin
4) Confidence 0.49 Published 1998 Journal Brain Res. Section Title Doc Link 9630549 Disease Relevance 0 Pain Relevance 0.19
We conclude that stimulation with 5-hydroxytryptophan or 5-HT agonists increases mRNA expression of oxytocin in the PVN and the SON via stimulation of at least 5-HT1A, 5-HT1B, 5-HT2A and 5-HT2C receptors.
Positive_regulation (stimulation) of 5-HT1B in PVN associated with agonist
5) Confidence 0.49 Published 2003 Journal J. Neuroendocrinol. Section Abstract Doc Link 12716407 Disease Relevance 0 Pain Relevance 0.42
Low densities of the 5-HT1D recognition sites were found to be present in globus pallidus, ventral pallidum, caudate-putamen, subthalamic nucleus, entopeduncular nucleus, substantia nigra (reticular part), nuclei of the (normal and accessory) optic tract, different nuclei of the geniculate body and frontoparietal cortex, although higher densities of 5-HT1B sites were always observed in the same structures.
Positive_regulation (densities) of 5-HT1B in substantia nigra associated with substantia nigra
6) Confidence 0.49 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8361548 Disease Relevance 0 Pain Relevance 0.28
The present cellular findings indicate that the anti-migraine drug sumatriptan activates, or disinhibits descending analgesic pathways from within the PAG via activation of 5-HT1B and 5-HT1D receptors.
Positive_regulation (activation) of 5-HT1B associated with sumatriptan, periaqueductal grey, analgesic and migraine
7) Confidence 0.45 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 1.03 Pain Relevance 1.68
M) all produced a significant increase in the ratio of evoked IPSC2/IPSC1 (Figure 1c, e, p = 0.003, 0.04, 0.03, n = 21, 7, 14).

5-HT1A, 5-HT1B and 5-HT1D receptor activation inhibits GABAergic synaptic transmission

Positive_regulation (increase) of 5-HT1B associated with gabaergic
8) Confidence 0.45 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.32 Pain Relevance 0.59
The activation of spinal 5-HT1A may result analgesia [62,63] (see also [64]), or hyperalgesia [65,66], while the activation of spinal 5-HT1B receptors produces antinociception [67,68].
Positive_regulation (activation) of 5-HT1B in spinal associated with antinociception, hyperalgesia and analgesia
9) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC2860347 Disease Relevance 0.54 Pain Relevance 0.90
We evaluated whether the anxiolytic effects of selective serotonin reuptake inhibitors (SSRIs) in the rat ultrasonic vocalization (USV) test are preferentially mediated by (indirect) activation of 5-HT1A, 5-HT1B/1D, 5-HT2A, 5-HT3 or 5-HT4 receptors.
Positive_regulation (activation) of 5-HT1B associated with anxiety disorder and ssri
10) Confidence 0.45 Published 1998 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9539263 Disease Relevance 0.26 Pain Relevance 0.44
Serotonin1B receptor activation mimics behavioral effects of presynaptic serotonin release.
Positive_regulation (activation) of Serotonin1B receptor associated with serotonin
11) Confidence 0.28 Published 1993 Journal Neuropsychopharmacology Section Title Doc Link 8099482 Disease Relevance 0.17 Pain Relevance 0.31
These data suggest that 5-HT1A and 5-HT1B receptor subtypes mediate the facilitatory effect of 5-HT on nociceptive processing in the spinal cord of rats.
Positive_regulation (mediate) of 5-HT1B in spinal cord associated with nociception and spinal cord
12) Confidence 0.21 Published 2001 Journal Pain Section Abstract Doc Link 11323141 Disease Relevance 0.23 Pain Relevance 0.73
Low densities of the 5-HT1D recognition sites were found to be present in globus pallidus, ventral pallidum, caudate-putamen, subthalamic nucleus, entopeduncular nucleus, substantia nigra (reticular part), nuclei of the (normal and accessory) optic tract, different nuclei of the geniculate body and frontoparietal cortex, although higher densities of 5-HT1B sites were always observed in the same structures.
Positive_regulation (densities) of 5-HT1B in caudate-putamen associated with substantia nigra
13) Confidence 0.17 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8361548 Disease Relevance 0 Pain Relevance 0.28
Low densities of the 5-HT1D recognition sites were found to be present in globus pallidus, ventral pallidum, caudate-putamen, subthalamic nucleus, entopeduncular nucleus, substantia nigra (reticular part), nuclei of the (normal and accessory) optic tract, different nuclei of the geniculate body and frontoparietal cortex, although higher densities of 5-HT1B sites were always observed in the same structures.
Positive_regulation (densities) of 5-HT1B in entopeduncular nucleus associated with substantia nigra
14) Confidence 0.17 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8361548 Disease Relevance 0 Pain Relevance 0.28
Low densities of the 5-HT1D recognition sites were found to be present in globus pallidus, ventral pallidum, caudate-putamen, subthalamic nucleus, entopeduncular nucleus, substantia nigra (reticular part), nuclei of the (normal and accessory) optic tract, different nuclei of the geniculate body and frontoparietal cortex, although higher densities of 5-HT1B sites were always observed in the same structures.
Positive_regulation (densities) of 5-HT1B in subthalamic nucleus associated with substantia nigra
15) Confidence 0.17 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8361548 Disease Relevance 0 Pain Relevance 0.28
Low densities of the 5-HT1D recognition sites were found to be present in globus pallidus, ventral pallidum, caudate-putamen, subthalamic nucleus, entopeduncular nucleus, substantia nigra (reticular part), nuclei of the (normal and accessory) optic tract, different nuclei of the geniculate body and frontoparietal cortex, although higher densities of 5-HT1B sites were always observed in the same structures.
Positive_regulation (densities) of 5-HT1B in pallidum associated with substantia nigra
16) Confidence 0.17 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8361548 Disease Relevance 0 Pain Relevance 0.28

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