INT56590

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Context Info
Confidence 0.28
First Reported 1993
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.64
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Atp2b4)
Anatomy Link Frequency
myocyte 1
medulla 1
mesencephalon 1
cerebellum 1
Atp2b4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
halothane 13 99.58 Very High Very High Very High
ischemia 3 98.78 Very High Very High Very High
Pain 4 97.24 Very High Very High Very High
isoflurane 8 95.24 Very High Very High Very High
medulla 3 94.12 High High
Clonidine 2 79.36 Quite High
cerebral cortex 2 76.16 Quite High
tetrodotoxin 1 60.00 Quite High
Inflammation 2 45.44 Quite Low
adenocard 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 3 98.78 Very High Very High Very High
Obesity 15 97.96 Very High Very High Very High
Pain 4 97.24 Very High Very High Very High
Injury 8 94.88 High High
Hypoxia 1 89.12 High High
Aging 3 78.52 Quite High
Sprains And Strains 3 77.68 Quite High
Disease 3 76.72 Quite High
Stress 11 63.92 Quite High
INFLAMMATION 2 45.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dose dependent stimulation of PMCA pumping was observed in synaptic membranes from both types, but insulin concentrations in extracts of diencephalon-mesencephalon, cerebellum, and medulla (but not cortex) were higher in obese than in lean Zucker rats.
Positive_regulation (stimulation) of PMCA in medulla associated with medulla and obesity
1) Confidence 0.28 Published 1996 Journal Life Sci. Section Abstract Doc Link 8890928 Disease Relevance 0.60 Pain Relevance 0.35
Thus, the pharmacodynamic effects of the agents tested should also be related to the changes induced in the activity of some specific synaptosomal non-mitochondrial ATPases.
Positive_regulation (induced) of ATPases
2) Confidence 0.22 Published 1993 Journal Neurochem. Res. Section Abstract Doc Link 8099718 Disease Relevance 0 Pain Relevance 0.21
For F344/BNF1 rats, MED for halothane was reduced to 87%, PMCA activity was diminished to 90% in cortical SPM and 72% DM SPM, and PLMTI activity was increased to 133% in cortical SPM and 112% in DM SPM.
Positive_regulation (increased) of PMCA associated with halothane
3) Confidence 0.19 Published 1996 Journal Life Sci. Section Abstract Doc Link 8890927 Disease Relevance 0.34 Pain Relevance 0.32
Dose dependent stimulation of PMCA pumping was observed in synaptic membranes from both types, but insulin concentrations in extracts of diencephalon-mesencephalon, cerebellum, and medulla (but not cortex) were higher in obese than in lean Zucker rats.
Positive_regulation (stimulation) of PMCA in mesencephalon associated with medulla and obesity
4) Confidence 0.09 Published 1996 Journal Life Sci. Section Abstract Doc Link 8890928 Disease Relevance 0.60 Pain Relevance 0.35
Dose dependent stimulation of PMCA pumping was observed in synaptic membranes from both types, but insulin concentrations in extracts of diencephalon-mesencephalon, cerebellum, and medulla (but not cortex) were higher in obese than in lean Zucker rats.
Positive_regulation (stimulation) of PMCA in cerebellum associated with medulla and obesity
5) Confidence 0.09 Published 1996 Journal Life Sci. Section Abstract Doc Link 8890928 Disease Relevance 0.60 Pain Relevance 0.35
Sulphated polysaccharides co-administration restored the activities of these ATPases near to that of controls, thereby showing its beneficial effect in maintaining the membrane integrity.
Positive_regulation (restored) of ATPases
6) Confidence 0.08 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2291455 Disease Relevance 0.06 Pain Relevance 0
During ischemia, myocyte Ca(2+) overload can contribute to ATP depletion by activation of Ca(2+)-dependent ATPases and by induction of the mitochondrial permeability transition, and thus is an important contributor to myocyte dysfunction and injury.
Positive_regulation (activation) of ATPases in myocyte associated with ischemia and injury
7) Confidence 0.01 Published 2006 Journal J. Cardiovasc. Electrophysiol. Section Abstract Doc Link 16686681 Disease Relevance 0.44 Pain Relevance 0.18

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