INT56594

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 10.17
Pain Relevance 4.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4) extracellular region (Il4)
Anatomy Link Frequency
Dendritic cell 4
T cell 4
inguinal lymph nodes 3
PSP 2
spleen 1
Il4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 335 100.00 Very High Very High Very High
Inflammation 307 99.64 Very High Very High Very High
rheumatoid arthritis 107 99.62 Very High Very High Very High
narcan 1 98.80 Very High Very High Very High
anesthesia 9 98.76 Very High Very High Very High
transdermal 14 98.16 Very High Very High Very High
agonist 49 97.84 Very High Very High Very High
Opioid 3 97.76 Very High Very High Very High
chemokine 42 94.36 High High
Arthritis 51 90.28 High High
Disease Link Frequency Relevance Heat
Asthma 84 100.00 Very High Very High Very High
INFLAMMATION 331 99.64 Very High Very High Very High
Rheumatoid Arthritis 107 99.62 Very High Very High Very High
Sprains And Strains 59 97.64 Very High Very High Very High
Multiple Sclerosis 4 95.52 Very High Very High Very High
Synovitis 21 94.56 High High
Adhesions 12 94.32 High High
Colitis 75 94.12 High High
Targeted Disruption 49 92.80 High High
Immunization 114 90.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Splenocytes were obtained and cultured in vitro with H. pylori sonicate to evaluate induction of interferon gamma (IFN-gamma) and interleukin 4 (IL-4) secretion.
Positive_regulation (induction) of Localization (secretion) of IL-4
1) Confidence 0.48 Published 2003 Journal Int. Immunopharmacol. Section Abstract Doc Link 12810355 Disease Relevance 0.64 Pain Relevance 0.15
Beta-endorphin stimulates Ia expression on mouse B cells by inducing interleukin-4 secretion by CD4+ T cells.
Positive_regulation (inducing) of Localization (secretion) of interleukin-4 in T cells associated with narcan
2) Confidence 0.38 Published 1993 Journal Cell. Immunol. Section Title Doc Link 8099850 Disease Relevance 0 Pain Relevance 0.15
Splenocytes were obtained and cultured in vitro with H. pylori sonicate to evaluate induction of interferon gamma (IFN-gamma) and interleukin 4 (IL-4) secretion.
Positive_regulation (induction) of Localization (secretion) of interleukin 4
3) Confidence 0.35 Published 2003 Journal Int. Immunopharmacol. Section Abstract Doc Link 12810355 Disease Relevance 0.64 Pain Relevance 0.15
In this model, the inflammation is characterized by increased IL-4 and IL-5 secretion and the inflammation can be ameliorated by the administration of anti-IL-4 antibodies (15).
Positive_regulation (increased) of Localization (secretion) of IL-4 associated with inflammation
4) Confidence 0.32 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 1.17 Pain Relevance 0.13
secretion as well as impaired Th1 polarization in vitro, while IL-4 secretion was enhanced under the Th2 condition (13).
Positive_regulation (enhanced) of Localization (secretion) of IL-4
5) Confidence 0.30 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.44 Pain Relevance 0.06
Dendritic cell differentiation in a cholestatic hepatic environment may lead to Th2 polarization and secretion of IL4 and IL10, rather than IFN?
Spec (may) Positive_regulation (lead) of Localization (secretion) of IL4 in Dendritic cell
6) Confidence 0.27 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2637833 Disease Relevance 0.88 Pain Relevance 0.18
asthma, including the secretion of cytokines such as IL-4, IL-5, and IL-13,
Positive_regulation (as) of Localization (secretion) of IL-4 associated with asthma and cytokine
7) Confidence 0.24 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.49 Pain Relevance 0.10
asthma, including the secretion of cytokines such as IL-4, IL-5, and IL-13,
Positive_regulation (asthma) of Localization (secretion) of IL-4 associated with asthma and cytokine
8) Confidence 0.24 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.49 Pain Relevance 0.10
Interestingly, the cellular and humoral responses generated using the transdermal route were skewed predominantly to Th2 when compared to IM, likely a consequence of higher levels of IL-4 secretion from spleen and inguinal lymph nodes.
Positive_regulation (levels) of Localization (secretion) of IL-4 in inguinal lymph nodes associated with transdermal
9) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651574 Disease Relevance 0.33 Pain Relevance 0.11
BALB/cA mice responded with a non-significant but consistent increase in IL-4 cytokine release in OVA-treated mice, whereas NIH mice responded with a significantly increased Th2-biased (IL-4 and IL-10) cytokine release in PSP-treated mice.
Positive_regulation (increase) of Localization (release) of IL-4 in PSP associated with cytokine
10) Confidence 0.22 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1182367 Disease Relevance 0.24 Pain Relevance 0.30
Dendritic cell differentiation in a cholestatic hepatic environment may lead to Th2 polarization and secretion of IL4 and IL10, rather than IFN?
Positive_regulation (than) of Localization (secretion) of IL4 in Dendritic cell
11) Confidence 0.20 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2637833 Disease Relevance 0.88 Pain Relevance 0.18
Thus, further study is needed to clarify cell types, including efficiency of transfection, which cells take up the IL-4pDNA and how long the expression of the IL-4pDNA lasts, including how secreted IL-4 protein affects IL-4 receptor since the IL-4?
Positive_regulation (since) of Localization (secreted) of IL-4
12) Confidence 0.15 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2933908 Disease Relevance 0.16 Pain Relevance 0.06
Patients with early RA had significantly elevated synovial levels of IL-2, IL-4, IL-13, IL-17, EGF and bFGF when compared with patients with established RA (Figs 1 and 2, and Table 2).
Positive_regulation (elevated) of Localization (levels) of IL-4 associated with rheumatoid arthritis
13) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175027 Disease Relevance 2.21 Pain Relevance 0.94
The photooxidized grafts did not induce a significant T cell response to collagen over what was seen in sham treated control mice, while the unprocessed graft produced an elevated IL-4 response versus the negative controls.
Positive_regulation (elevated) of Localization (response) of IL-4 in T cell
14) Confidence 0.10 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1459156 Disease Relevance 0 Pain Relevance 0.07
Intriguingly, vaults containing another protein, GL, but not empty vaults, also significantly induced the maturation of BMDC by causing secretion of IL-12p70, IL-10 and CXCL10 but not IL-4 (data not shown) suggesting that vaults containing proteins favor induction of Th1 immune responses.
Positive_regulation (induced) of Localization (secretion) of IL-4
15) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671841 Disease Relevance 0.31 Pain Relevance 0.40
Interestingly, the cellular and humoral responses generated using the transdermal route were skewed predominantly to Th2 when compared to IM, likely a consequence of higher levels of IL-4 secretion from spleen and inguinal lymph nodes.
Positive_regulation (levels) of in spleen Localization (secretion) of IL-4 in inguinal lymph nodes associated with transdermal
16) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651574 Disease Relevance 0.33 Pain Relevance 0.11
Surgery also contributes to the deviation of the immune response toward a Th2 and patients undergoing surgery and anesthesia have shown to present with down-regulated IL-2 secretion and up-regulated IL-10 and IL-4 secretion during the postoperative period.[34] However, in our study these confounding factors did not play much role as all patients underwent surgical procedures of almost similar duration, same type of anesthesia and single team of surgeons.
Positive_regulation (up) of Localization (secretion) of IL-4 associated with anesthesia and cytokine
17) Confidence 0.08 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2937301 Disease Relevance 0.17 Pain Relevance 0.32
led to marked increases in Interleukin-4 (IL-4) release.
Positive_regulation (increases) of Localization (release) of IL-4
18) Confidence 0.07 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551585 Disease Relevance 0.79 Pain Relevance 0.63

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox