INT5660

Context Info Confidence 0.48 First Reported 1982 Last Reported 2010 Negated 9 Speculated 24 Reported most in Abstract Documents 477 Total Number 501 Disease Relevance 71.86 Pain Relevance 342.06

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)

Anatomy Link Frequency brain 55 NG108-15 8 striatum 7 nucleus accumbens 5 ileum 4 Oprd1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat opioid receptor 3119 100.00 Opioid 1584 100.00 Morphine 1118 100.00 Pain 783 100.00 agonist 769 100.00 antagonist 609 100.00 narcan 511 100.00 Enkephalin 502 100.00 Analgesic 501 100.00 Buprenorphine 235 100.00

Disease Link Frequency Relevance Heat Alcohol Addiction 89 100.00 Shock 39 100.00 Adhesions 14 100.00 Targeted Disruption 122 99.96 Stress 78 99.92 Pain 777 99.80 Opiate Addiction 67 99.76 Cocaine Dependence 9 99.68 Morphine Dependence 1 99.68 Nociception 157 99.66

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In contrast, administration of the nonselective opioid receptor alkylating antagonist beta-chlornaltexamine (beta-CNA) over a similar range of doses was found to be nonselective for either delta radioligand, and produced greater inhibition of Oprm1 relative to Oprd1 binding, consistent with the nonselective pharmacological activity of this antagonist.

Oprd1 Binding (binding) of associated with antagonist and opioid receptor

1) Confidence 0.48 Published 2006 Journal Synapse Section Abstract Doc Link 16847946 Disease Relevance 0 Pain Relevance 0.59

The influence of replacing the phenolic hydroxyl by the methoxy group on opioid receptor binding, analgesic and antitussive action was investigated in the corresponding couples morphine-codeine, hydromorphone-hydrocodone and O-desmethyltramadol (L 235)-tramadol.

opioid receptor Binding (binding) of associated with tramadol, analgesic, opioid receptor, codeine and morphine

2) Confidence 0.48 Published 1988 Journal Arzneimittelforschung Section Abstract Doc Link 2849950 Disease Relevance 0.06 Pain Relevance 0.94

Reversal by naloxone of the morphine-induced depression of the cutaneo-adrenal nerve reflexes indicates that the opioid receptor is associated with these effects of morphine.

opioid receptor Binding (associated) of in nerve associated with depression, narcan, opioid receptor and morphine

3) Confidence 0.48 Published 1985 Journal Neurosci. Lett. Section Abstract Doc Link 4069457 Disease Relevance 0.10 Pain Relevance 0.67

These differences for the effects of butorphanol from those of morphine and pentazocine seemed to result from the antagonist-agonist property of butorphanol and from a different manner of interaction with the opioid receptor.

opioid receptor Binding (interaction) of associated with fortral, antagonist, agonist, butorphanol, opioid receptor and morphine

4) Confidence 0.48 Published 1985 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2419614 Disease Relevance 0 Pain Relevance 2.18

Repeated restraint stress reduces opioid receptor binding in different rat CNS structures.

opioid receptor Binding (binding) of associated with stress, narcan and opioid receptor

5) Confidence 0.48 Published 2005 Journal Neurochem. Res. Section Title Doc Link 15756926 Disease Relevance 0.55 Pain Relevance 0.50

Other derivatives were synthesized as a control using a tripeptide which does not bind to the opioid receptor.

opioid receptor Neg (not) Binding (bind) of associated with opioid receptor

6) Confidence 0.48 Published 1987 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 2826357 Disease Relevance 0.07 Pain Relevance 0.42

Perineural block produced by meperidine was attributed to local anesthetic-like effect, rather than to drug interaction with opioid receptor.

opioid receptor Binding (interaction) of

7) Confidence 0.48 Published 2001 Journal Acta Anaesthesiol Scand Section Body Doc Link 11472295 Disease Relevance 0 Pain Relevance 0

Enhanced binding of morphine and nalorphine to opioid delta receptor by glucuronate and sulfate conjugations at the 6-position.

opioid delta receptor Binding (binding) of associated with opioid and morphine

8) Confidence 0.48 Published 1987 Journal Life Sci. Section Title Doc Link 3041142 Disease Relevance 0 Pain Relevance 0.87

Heterogeneity of opioid receptor binding in brain slices.

opioid receptor Binding (binding) of in brain associated with opioid receptor and immobilon

9) Confidence 0.48 Published 1987 Journal J. Neurosci. Res. Section Title Doc Link 2891857 Disease Relevance 0 Pain Relevance 0.74

These results suggest that eptazocine interacts with opioid receptor, and is classified as one of the opiate agonist-antagonist analgesics.

opioid receptor Binding (interacts) of associated with analgesic, antagonist, agonist, opiate and opioid receptor

10) Confidence 0.48 Published 1985 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 2992058 Disease Relevance 0 Pain Relevance 0.60

Prenatal exposure to morphine differentially alters gonadal hormone regulation of delta-opioid receptor binding in male and female rats.

delta-opioid Binding (binding) of in gonadal associated with opioid receptor and morphine

11) Confidence 0.48 Published 2000 Journal Brain Res. Bull. Section Title Doc Link 11179845 Disease Relevance 0.42 Pain Relevance 0.80

These compounds were tested for opioid receptor binding in rat brain synaptosomal plasma membranes and for biological activity on the guinea pig ileum.

opioid receptor Binding (binding) of in ileum associated with opioid receptor

12) Confidence 0.48 Published 1983 Journal Life Sci. Section Abstract Doc Link 6319896 Disease Relevance 0 Pain Relevance 0.55

The effect of zinc (Zn2+) and several other trace elements was studied on the binding of the opioid receptor agonists [3H] DAGO [( ([Tyr-D-Ala-Gly-Methyl-Phe-Glyol]-enkephalin)a, [3H] DSTLE ([Tyr-D-Ser-Gly-Phe-Leu-Thr]-enkephalin) and [3H] EKC (ethylketocyclazocine), which are specific for the mu, delta and kappa opioid receptors, respectively, in the cerebral cortex of the rat.

opioid receptor Binding (binding) of in cerebral cortex associated with kappa opioid receptor, agonist, enkephalin, opioid receptor and cerebral cortex

13) Confidence 0.47 Published 1990 Journal Neuropharmacology Section Abstract Doc Link 2162496 Disease Relevance 0 Pain Relevance 0.48

Magnesium and manganese were stimulatory to opioid receptor binding, whereas cobalt and nickel had dual (stimulatory and inhibitory) effects.

opioid receptor Binding (binding) of associated with opioid receptor

14) Confidence 0.47 Published 1990 Journal Neuropharmacology Section Abstract Doc Link 2162496 Disease Relevance 0 Pain Relevance 0.46

The present study was designed to examine the effects of interfering with opioid-receptor interaction during re-epithelialization of the cornea in the rat using both systemic injections and topical applications of the potent opioid antagonist naltrexone (NTX).

opioid-receptor Binding (interaction) of in cornea associated with antagonist and opioid

15) Confidence 0.47 Published 1998 Journal Brain Res. Section Abstract Doc Link 9666142 Disease Relevance 0 Pain Relevance 0.55

Measurement of changes in opioid receptor binding in vivo during trigeminal neuralgic pain using [11C] diprenorphine and positron emission tomography.

opioid receptor Binding (binding) of associated with pain, positron emission tomography and opioid receptor

16) Confidence 0.46 Published 1999 Journal J. Cereb. Blood Flow Metab. Section Title Doc Link 10413036 Disease Relevance 0.55 Pain Relevance 0.75

Central poststroke pain and reduced opioid receptor binding within pain processing circuitries: a [11C]diprenorphine PET study.

opioid receptor Binding (binding) of associated with pain, opioid receptor and poststroke pain

17) Confidence 0.46 Published 2004 Journal Pain Section Title Doc Link 15030940 Disease Relevance 0.56 Pain Relevance 1.06

These behavioral responses in stress are accompanied by changes in the contents of opioid peptides, the mRNAs encoding their precursors and opioid receptor binding in the brain.

opioid receptor Binding (binding) of in brain associated with stress, opioid receptor and opioid

18) Confidence 0.46 Published 1995 Journal Behav. Brain Res. Section Abstract Doc Link 7779288 Disease Relevance 0.56 Pain Relevance 0.96

Mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine abuse: synthesis and opioid receptor binding affinity of N-substituted derivatives of morphinan.

opioid receptor Binding (affinity) of associated with mu agonist, antagonist, agonist, opioid receptor and cocaine

19) Confidence 0.46 Published 2001 Journal Bioorg. Med. Chem. Lett. Section Title Doc Link 11591513 Disease Relevance 0.10 Pain Relevance 0.39

The possibility of different modes of interaction with a single opioid receptor population also is discussed.

opioid receptor Binding (interaction) of associated with opioid receptor

20) Confidence 0.46 Published 1982 Journal J. Med. Chem. Section Abstract Doc Link 6284938 Disease Relevance 0 Pain Relevance 0.36

General Comments

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