INT56610

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Context Info
Confidence 0.10
First Reported 1993
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 5.40
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Chka) cytoplasm (Chka)
Anatomy Link Frequency
covering 6
ovary 2
Chka (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 5 95.48 Very High Very High Very High
Endep 1 73.92 Quite High
Serotonin 1 60.88 Quite High
fluoxetine 1 57.60 Quite High
antagonist 4 48.80 Quite Low
corticosteroid 9 35.76 Quite Low
Central nervous system 3 21.00 Low Low
chemokine 15 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 84 99.68 Very High Very High Very High
Breast Cancer 38 99.24 Very High Very High Very High
Leukemia 21 98.88 Very High Very High Very High
Lymphatic System Cancer 366 98.50 Very High Very High Very High
Cancer 177 94.84 High High
Necrosis 1 90.76 High High
Hodgkin's Disease 75 90.48 High High
Multiple Myeloma 21 89.28 High High
Carcinoma 16 86.32 High High
Mantle-cell Lymphoma 99 84.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Major CK alterations observed in breast cancer could be reflected by the reduced or increased expression of individual CK, and by partial loss of the normal regulation of CK expression [45].
Positive_regulation (increased) of Gene_expression (expression) of CK associated with breast cancer
1) Confidence 0.10 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC549166 Disease Relevance 0.92 Pain Relevance 0
Using tissue microarray technology, 1,059 lymphoma and acute leukemia cases, covering the most common disease entities, were tested for aberrant CK expression using CK22.
Positive_regulation (using) of Gene_expression (expression) of CK in covering associated with leukemia, lymphatic system cancer and disease
2) Confidence 0.05 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.49 Pain Relevance 0
Using tissue microarray technology, 1,059 lymphoma and acute leukemia cases, covering the most common disease entities, were tested for aberrant CK expression using CK22.
Positive_regulation (aberrant) of Gene_expression (expression) of CK in covering associated with leukemia, lymphatic system cancer and disease
3) Confidence 0.05 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.49 Pain Relevance 0
Using tissue microarray technology, 1,059 lymphoma and acute leukemia cases, covering the most common disease entities, were tested for aberrant CK expression using CK22.
Positive_regulation (tested) of Gene_expression (expression) of CK in covering associated with leukemia, lymphatic system cancer and disease
4) Confidence 0.05 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.50 Pain Relevance 0
Using Chinese hamster ovary cells (CHO-K1) transfected with genes for the human muscarinic receptor subtypes, we obtained equilibrium dissociation constants (Kds) from competitive radioligand binding studies with [3H]-quinuclidinyl benzilate ([3H]QNB) and membranal preparations of these cells.
Positive_regulation (transfected) of Gene_expression (transfected) of CHO-K1 in ovary
5) Confidence 0.00 Published 1993 Journal Biochem. Pharmacol. Section Abstract Doc Link 8100134 Disease Relevance 0 Pain Relevance 0.30

General Comments

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